Fibrolamellar hepatic tumor with neurosecretory features and systemic deposition of AA amyloid.

Abstract:

:A 28-year-old man presented with left cervical lymph node metastases and a 7-cm mass in the left lobe of the liver. Biopsy material from both sites revealed a fibrolamellar hepatocarcinoma (FLHC) with immunocytochemical and ultrastructural evidence of neurosecretory differentiation. The patient refused treatment. He died 6 years after the onset of symptoms with grade IV coma and bilateral bronchopneumonia. Postmortem examination disclosed persistent neoplastic disease in the liver and left lateral cervical lymph nodes as well as widespread deposition of AA amyloid in tumor stroma and in blood vessel walls of many tissues but mainly in the kidney, gastrointestinal tract, and heart. This appears to be the first report documenting the association of FLHC and amyloid deposition in the English literature.

journal_name

Ultrastruct Pathol

authors

Lloreta J,Vadell C,Fabregat X,Serrano S

doi

10.3109/01913129409016302

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

287-92

issue

1-2

eissn

0191-3123

issn

1521-0758

journal_volume

18

pub_type

杂志文章
  • Glial fibrillary acidic protein (GFAP) immunoreactivity in peripheral nerve sheath tumors.

    abstract::A spectrum of 24 benign and malignant nerve sheath tumors and 10 non-neural spindle-cell tumors were studied by light microscopy for the presence of glial fibrillary acidic protein (GFAP) immunoreactivity by the peroxidase-antiperoxidase (PAP) technique. In 8 cases, these results were compared to their electron micros...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141487

    authors: Memoli VA,Brown EF,Gould VE

    更新日期:1984-01-01 00:00:00

  • Ultrastructural analysis of the oocytes of female Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) ticks subjected to the action of Azadirachta indica A. Juss (neem).

    abstract::The present study provides ultrastructural information about the acaricidal effects of neem (Azadirachta indica A. Juss) on the ovaries of R. sanguineus engorged females. In general, the main damage caused in the oocytes was alteration in the shape of the cell and of the germinal vesicle, ring-shaped nucleolus, cytopl...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2011.588819

    authors: Denardi SE,Bechara GH,de Oliveira PR,Mathias MI

    更新日期:2012-02-01 00:00:00

  • Ultrastructural myopathology in the molecular era.

    abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913123.2013.810690

    authors: Goebel HH,Stenzel W

    更新日期:2013-10-01 00:00:00

  • The ultrastructure of hybrid acute leukemia: a study of 15 cases.

    abstract::The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131290968722

    authors: Ru YX,Wang HJ,Yang BX,Liu JH,Li ZQ,Li CW,Wang JX,Mi YC

    更新日期:2005-09-01 00:00:00

  • Pathology of rotavirus infection in suckling mice: A study by conventional histology, immunofluorescence, ultrathin sections, and scanning electron microscopy.

    abstract::Pathologic changes induced in the small intestine of suckling mice by rotavirus infection were studied by conventional histology, immunofluorescence, scanning electron microscopy, and electron microscopy of ultrathin sections. Infection could be detected within 24 hours in a few mice, but after 2 days it was well esta...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128109031504

    authors: Coelho KI,Bryden AS,Hall C,Flewett TH

    更新日期:1981-01-01 00:00:00

  • Disseminated tubuloreticular inclusions in acquired immunodeficiency syndrome (AIDS).

    abstract::Tissue biopsies and peripheral blood samples from 10 patients with the characteristic clinical features of acquired immunodeficiency syndrome (AIDS) were examined by electron microscopy and ultracytochemical myeloperoxidase technique. Abundant tubuloreticular inclusions (TRI) were detected within the endoplasmic retic...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140585

    authors: Kostianovsky M,Kang YH,Grimley PM

    更新日期:1983-06-01 00:00:00

  • Meningeal melanocytoma: a case report and literature review.

    abstract::The clinicopathologic, immunocytochemical, and electron microscopic features of a case of meningeal melanocytoma arising in the phylum terminale are reported. Meningeal melanocytoma is an uncommon tumor that must be distinguished from metastatic or primary malignant melanoma, meningeal melanocytic nevi, pigmented meni...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913129809103356

    authors: Alameda F,Lloreta J,Galitó E,Roquer J,Serrano S

    更新日期:1998-07-01 00:00:00

  • Multiple wall in-folds sub-divide single segments during capillary regression in hyperoxic acute lung injury.

    abstract::The present study provides further insight into the structural processes that remodel pulmonary capillaries in the injured adult lung. Early in hyperoxia acute lung injury (HALI), many sub-dividing segments are present throughout the capillary network before segment occlusion and loss predominate and capillary density...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2014.888113

    authors: Jones RC,Capen DE

    更新日期:2014-05-01 00:00:00

  • Insular amyloid in a case of type III glycogenosis with a special reference to the origin of amyloid fibrils.

    abstract::Amyloid depositions of pancreatic islets were investigated with electron microscopy in a case of type III glycogenosis. Beta cells adjoining small amyloid depositions were shown to have cytoplasmic invaginations where closely packed amyloid fibrils were disclosed regularly orientated amyloid bundles. In the cytoplasm ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609032222

    authors: Takahashi M,Yokota T,Ishihara T,Uchino F,Kamei T

    更新日期:1986-01-01 00:00:00

  • Comparison of ultrastructural features among neuroblastic tumors: maturation from neuroblastoma to ganglioneuroma.

    abstract::Neuroblastic tumors have the unique ability to differentiate and mature. This family of tumors is composed of the neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. These tumors are derived from primordial neural crest cells that form the sympathetic nervous system. The purpose of this study was to characterize ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129509064236

    authors: Hicks MJ,Mackay B

    更新日期:1995-07-01 00:00:00

  • Prolonged storage of fixative for electron microscopy: effects on tissue preservation for diagnostic specimens.

    abstract::Prolonged storage of Karnovsky's fixative, at both 4 and -20 degrees C, is possible in the diagnostic electron microscopy setting. Ultrastructural detail was not compromised in specimens processed in fixative that had been stored for 6 months. Evidence of smooth muscle and neuroendocrine differentiation was present in...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709021318

    authors: Mount SL,Schwarz JE,Taatjes DJ

    更新日期:1997-03-01 00:00:00

  • Ultrastructural study across the leprosy spectrum.

    abstract::We have carried out a systematic ultrastructural study of the bacilli, the cell-mediated response in the host, and the dermal microvasculature in lepromatous (LL), borderline lepromatous (BL), and borderline tuberculoid (BT) types of active leprosy (eight cases). In the types of least resistance (LL and BL), macrophag...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129409023213

    authors: Ortega VV,Martínez Díaz F,Ortuño Pacheco G,Calderón Rubiales F

    更新日期:1994-07-01 00:00:00

  • Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy.

    abstract::Lymphoma diagnosis rarely needs electron microscopy (EM), but one area where it can be useful is in the distinction of cytokeratin-positive lymphoma from carcinoma. The authors describe such a case, where difficulties were encountered due to lack of antibody specificity, distinguishing reactive from tumoral cells, and...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802625830

    authors: Eyden B,Chakrabarty B,Hatimy U

    更新日期:2009-01-01 00:00:00

  • Sclerosing stromal tumor of the ovary: an ultrastructural and immunohistochemical analysis with histogenetic considerations.

    abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209061364

    authors: Shaw JA,Dabbs DJ,Geisinger KR

    更新日期:1992-05-01 00:00:00

  • Xanthogranulomatous appendicitis--an incidental finding of localized pathology.

    abstract::The clinical, histopathological, and electron microscopic features of an unusual case of xanthogranulomatous appendicitis are reported. The patient, a 37-year-old female, presented with typical signs of acute appendicitis and the appendix appeared slightly dilated at laparatomy. The histopathological sections showed n...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131200281291

    authors: Munichor M,Kerner H,Cohen H,Bickel A,Iancu TC

    更新日期:2000-01-01 00:00:00

  • Inflammatory fibroid polyp of the small intestine: ultrastructural and immunohistochemical observations.

    abstract::The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histiocytic features, with ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913129009025123

    authors: Suster S,Robinson MJ

    更新日期:1990-03-01 00:00:00

  • Urachal cystadenoma with abundant glycogen: ultrastructural study.

    abstract::A cystadenoma arose in the urachus of a 32-year-old man. The mass was a multilocular cystic tumor filled with light yellow mucoid material. It was located in the anterior abdominal wall between the umbilicus and the dome of the urinary bladder. Overall, the mass was 14 cm x 8 cm x 5 cm, with the largest internal cyst ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129409023225

    authors: Hull MT,Warfel KA

    更新日期:1994-09-01 00:00:00

  • Intercellular junction formation between polymorphonuclear leukocytes, and between polymorphonuclear leukocytes and tumor cells.

    abstract::Morphologic evidence of intercellular junctions was found between polymorphonuclear leukocytes (PMNs) and between PMNs and tumor cells. All these junctions displayed electron-dense plaques along the plasma membranes with linear spaces in between. These plaques were finely granular and devoid of filaments. Fine granule...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309141835

    authors: Tang CK

    更新日期:1983-09-01 00:00:00

  • Renal malakoplakia: report of a case with multifocal involvement.

    abstract::The authors report the light microscopic and ultrastructural features in one case of malakoplakia involving the kidney, the urinary bladder, and the skin. The kidney was excised. Lesions of the urinary bladder and the skin regressed after topical treatment with cholinergic agonists and antimicrobial drugs. This case i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709016374

    authors: Lloreta J,Cañas MA,Munné A,Arumí M,Bielsa O,Gelabert A,Serrano S

    更新日期:1997-11-01 00:00:00

  • Low magnification transmission electron microscopy in diagnostic pathology.

    abstract::Transmission electron microscopy examination of selected diagnostic specimens, that is, renal and nerve biopsies, can be greatly facilitated by the implementation of slot grid preparations that are inherently devoid of any grid bars. Such preparations are conducive to screening and photography at both low and intermed...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128709048459

    authors: Rippstein P,Cavell S,Boivin M,Dardick I

    更新日期:1987-01-01 00:00:00

  • Metaplastic breast carcinoma invading chest wall.

    abstract::Metaplastic breast carcinoma refers to a heterogeneous group of neoplasms in which the typical glandular growth pattern of the tumor undergoes metaplasia, either epithelial or stromal. A 59-year-old woman presented with a breast mass that recurred in 1 year and showed invasion of the chest wall. Histological sections ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129509021916

    authors: Harb JM,Komorowski RA,Vitali CM

    更新日期:1995-09-01 00:00:00

  • Jaw osteonecrosis in patients treated with bisphosphonates: an ultrastructural study.

    abstract::Osteonecrosis of the jaw is a severe bone disorder traditionally associated with periodontal disease, local malignancy, chemotherapy, glucocorticoid therapy, or trauma. Recently a growing number of publications reported the occurrence of osteonecrosis of the jaw in patients undergoing treatment with bisphosphonates. T...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913121003729806

    authors: Perrotta I,Cristofaro MG,Amantea M,Russo E,De Fazio S,Zuccalà V,Conforti F,Amorosi A,Donato G,Tripepi S,Giudice M

    更新日期:2010-08-01 00:00:00

  • Primary ependymoma of the retropubic space in a male patient.

    abstract::We report a case of primary intraabdominal ependymoma arising in the retropubic space of a male patient. An incidental intraabdominal mass was discovered in a 51-year-old man. Radiological studies revealed a 10 cm, solid and cystic tumor located in the Retzius fossa. Microscopically, the lesion was characterized by mu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2020.1836104

    authors: Tasar Kapakli E,Kosemehmetoglu K,Kaymaz F,Akdogan B,Ozmen M,Baydar DE

    更新日期:2020-11-20 00:00:00

  • Renal cell carcinoma metastatic to a pituitary FSH/LH adenoma: case report and review of the literature.

    abstract::Abstract Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastati...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913123.2014.937843

    authors: Magnoli F,Finzi G,Riva C,Capella C

    更新日期:2014-12-01 00:00:00

  • Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel disease.

    abstract::Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel di...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.829150

    authors: Gul M,Kayhan B,Elbe H,Dogan Z,Otlu A

    更新日期:2015-02-01 00:00:00

  • Deciduoid mesothelioma: a report of 5 cases and literature review.

    abstract::Deciduoid mesothelioma was first described in young females and in the peritoneum, which led to the suggestion that deciduoid mesothelioma was a distinct subtype with specific clinical and pathologic features. Later reports, however, have shown that this type of mesothelioma may also occur in elderly people and in the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/0913120290104647

    authors: Shia J,Erlandson RA,Klimstra DS

    更新日期:2002-11-01 00:00:00

  • As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope.

    abstract::As You Like It, Part 3, is a continuation of the lectures given by the author (Ultra Path VIII and Ultra Path IX). It is a critical historical review of topics of interest to electron microscopists, attempting to show what went wrong and perhaps also why. The topics chosen this time demonstrate the prominent role elec...

    journal_title:Ultrastructural pathology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1080/019131201300343874

    authors: Ghadially FN

    更新日期:2001-05-01 00:00:00

  • Neuronal ceroid lipofuscinosis: an ultrastructural, genetic, and clinical study report.

    abstract::The term "neuronal ceroid lipofuscinosis" (NCL) describes a complex of inherited neurodegenerative conditions associated with storage of lipopigments in brain tissue. In 1989 Dyken proposed a classification of NCL based on the age, clinical symptoms, and ultrastructural aspects of the lipopigments. At the ultrastructu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131201300004681

    authors: Boldrini R,Biselli R,Santorelli FM,Bosman C

    更新日期:2001-01-01 00:00:00

  • Extrusion of amyloid fibrils to the extracellular space in experimental mesangial AL-amyloidosis: transmission and scanning electron microscopy studies and correlation with renal biopsy observations.

    abstract::In vitro studies have provided much information regarding the process of glomerular AL-amyloidogenesis. Research efforts have been successful in deciphering how glomerulopathic light chains interact with mesangial cells. The sequential steps involved in the genesis of amyloid fibrils include interactions with surface ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.861568

    authors: Teng J,Turbat-Herrera EA,Herrera GA

    更新日期:2014-04-01 00:00:00

  • Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.

    abstract::Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2018.1463337

    authors: Yalim S,Dağlıoğlu K,Coskun G,Polat S

    更新日期:2018-05-01 00:00:00