Multiple wall in-folds sub-divide single segments during capillary regression in hyperoxic acute lung injury.


:The present study provides further insight into the structural processes that remodel pulmonary capillaries in the injured adult lung. Early in hyperoxia acute lung injury (HALI), many sub-dividing segments are present throughout the capillary network before segment occlusion and loss predominate and capillary density decreases later in the period. A second segment sub-division triggered in regenerating capillaries after air breathing (post-HALI) demonstrates a similar mechanism of organization at a time of contrasting change in the capillary density. As we have previously reported, the process of segment sub-division includes in-folding of the endothelial-epithelial surface (alveolar-capillary membrane) to form inter-luminal structures (ILSs) and loops, with loop separation increasing segment number. Unexpectedly, the findings support remodeling of the capillary density by wall in-folding in acute lung injury, demonstrating a similar mechanism in capillary regression as well as in regeneration in the adult lung.


Ultrastruct Pathol


Jones RC,Capen DE




Has Abstract


2014-05-01 00:00:00












  • Embryonic ultrastructure as a guide in the diagnosis of tumors.

    abstract::The purpose of this article has been to illustrate the applications and limitations of comparing the ultrastructural morphology of certain poorly differentiated neoplasms with normal human embryonic tissues. The examples used--embryonal rhabdomyosarcoma, Wilms' tumor, and fibrous mesothelioma, in comparison with embry...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Dickersin GR

    更新日期:1987-01-01 00:00:00

  • An ultrastructural and immunohistochemical study of elastofibroma: CD 34, MEF-2, prominin 2 (CD133), and factor XIIIa-positive proliferating fibroblastic stromal cells connected by Cx43-type gap junctions.

    abstract::Elastofibromas have been described as ill-defined tumors, composed of fibroblastic stromal cells and a dense collagenous stroma. A total of 5 elastofibromas from 4 Japanese patients were examined by ultrastructural and immunohistochemical methods. The proliferating fibroblastic stromal cells in the lesion showed Cx43-...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Yamazaki K

    更新日期:2007-05-01 00:00:00

  • Low magnification transmission electron microscopy in diagnostic pathology.

    abstract::Transmission electron microscopy examination of selected diagnostic specimens, that is, renal and nerve biopsies, can be greatly facilitated by the implementation of slot grid preparations that are inherently devoid of any grid bars. Such preparations are conducive to screening and photography at both low and intermed...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Rippstein P,Cavell S,Boivin M,Dardick I

    更新日期:1987-01-01 00:00:00

  • As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope.

    abstract::As You Like It, Part 3, is a continuation of the lectures given by the author (Ultra Path VIII and Ultra Path IX). It is a critical historical review of topics of interest to electron microscopists, attempting to show what went wrong and perhaps also why. The topics chosen this time demonstrate the prominent role elec...

    journal_title:Ultrastructural pathology

    pub_type: 历史文章,杂志文章,评审


    authors: Ghadially FN

    更新日期:2001-05-01 00:00:00

  • Plexiform soft tissue tumor composed predominantly of perineurial fibroblasts (perineurioma).

    abstract::A 15-year-old girl presented with a small, indolent mass near the knee joint. Light microscopy revealed a peculiar myxoid plexiform tumor composed of cytologically bland cells. Interpretation of the initial biopsy material was controversial. Subsequent immunohistochemical studies revealed tumor cells to be strongly re...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Weidner N,Nasr A,Johnston J

    更新日期:1993-05-01 00:00:00

  • Hyaline inclusions in a synovial sarcoma following intra-arterial chemotherapy.

    abstract::Hyaline inclusions were noted in cells of a typical synovial sarcoma following intra-arterial chemotherapy. Ultrastructural study revealed that the inclusions were cytoplasmic aggregates of intermediate filaments. Since the inclusions were not present in the tumor prior to treatment, it is suggested that they may have...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Sajjad SM,Mackay B

    更新日期:1982-10-01 00:00:00

  • Focal ellipsoid deposits in the atrial myocytes of Syrian hamster.

    abstract::A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been speculated eventually to contain atrial natriuretic factor (ANF). The p...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Gilloteaux J,Jennes L,Stoeckel ME,Vanderhaeghen JJ

    更新日期:1994-01-01 00:00:00

  • Epithelioid variant of pleomorphic liposarcoma: a comparative immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelial malignancies.

    abstract::Pleomorphic liposarcoma (PL) is the least common subtype of liposarcoma, displaying a lipoblastic, malignant fibrous histiocytoma (MFH)-like and, less frequently, an epithelioid growth pattern. The epithelioid morphology in PL is still underrecognized and may closely simulate other epithelial neoplasms, mainly adrenal...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Huang HY,Antonescu CR

    更新日期:2002-09-01 00:00:00

  • Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.

    abstract::Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Eşrefoğlu M,Ara C

    更新日期:2010-10-01 00:00:00

  • Diagnostic electron microscopy on reembedded ("popped off") areas of large Spurr epoxy sections.

    abstract::A technique is described in which areas of large Spurr epoxy thick sections are directly popped off of glass slides by inverted Beem capsules filled with polymerized plastic. This technique allows the survey of large regions of tissue with the maintenance of tissue relationships and the selection of specific areas for...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: di Sant'Agnese PA,De Mesy-Jensen KL

    更新日期:1984-01-01 00:00:00

  • Monoclonal glomerulopathy with features of cryoglobulinemic glomerulopathy in murine multiple myeloma model.

    abstract::In vivo and animal models of monoclonal light chain-associated renal diseases are limited. The Vk*MYC transgenic model with multiple myeloma in 50-70 weeks old mice with renal involvement has been reported before, but detailed renal pathologic changes have not been well documented. This study fully investigated pathol...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Zhang PL,Herrera GA,Liu B

    更新日期:2020-11-20 00:00:00

  • Neuronal ceroid lipofuscinosis: an ultrastructural, genetic, and clinical study report.

    abstract::The term "neuronal ceroid lipofuscinosis" (NCL) describes a complex of inherited neurodegenerative conditions associated with storage of lipopigments in brain tissue. In 1989 Dyken proposed a classification of NCL based on the age, clinical symptoms, and ultrastructural aspects of the lipopigments. At the ultrastructu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Boldrini R,Biselli R,Santorelli FM,Bosman C

    更新日期:2001-01-01 00:00:00

  • Gastrointestinal stromal tumor of the stomach with rhabdoid phenotype: immunohistochemical, ultrastructural, and immunoelectron microscopic evaluation.

    abstract::A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Richmond JA,Mount SL,Schwarz JE

    更新日期:2004-05-01 00:00:00

  • Fatal pulmonary microsporidiosis due to encephalitozoon cuniculi following allogeneic bone marrow transplantation for acute myelogenous leukemia.

    abstract::Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of mic...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Orenstein JM,Russo P,Didier ES,Bowers C,Bunin N,Teachey DT

    更新日期:2005-05-01 00:00:00

  • Ultrastructure of poorly differentiated diffuse epithelial mesotheliomas.

    abstract::In differentiating diffuse epithelial mesothelioma from metastatic adenocarcinoma in pleural and peritoneal biopsies, the number and form of microvilli and the amount and distribution of tonofilaments are thought to be the most useful criteria. This report details 5 cases of diffuse epithelial mesothelioma in which th...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Dardick I,Al-Jabi M,McCaughey WT,Srigley JR,van Nostrand AW,Ritchie AC

    更新日期:1984-01-01 00:00:00

  • Myxoid liposarcoma: study of ten cases.

    abstract::The ultrastructure of 10 myxoid liposarcomas from 9 patients is presented. Features closely resembling those of developing fetal adipose tissue were seen in all tumors. THe various cell types identified ranged from undifferentiated cells to typical multivacuolated and univacuolated lipoblasts. In addition, a secretory...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Battifora H,Nunez-Alonso C

    更新日期:1980-04-01 00:00:00

  • Uncompacted myelin lamellae in peripheral nerve biopsy.

    abstract::Since 1979, the authors have studied 49 peripheral nerve biopsies presenting uncompacted myelin lamellae (UML). Based on the ultrastructural pattern of UML they propose a 3-category classification. The first category includes cases displaying regular UML, which was observed in 43 cases; it was more frequent in 9 cases...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Vital C,Vital A,Bouillot S,Favereaux A,Lagueny A,Ferrer X,Brechenmacher C,Petry KG

    更新日期:2003-01-01 00:00:00

  • Dose-dependent mercuric chloride tubular injury in rat kidney.

    abstract::Mercuric chloride (HgCl(2)) produces an acute renal failure in experimental animal models. Since the mechanism of tubular injury has not completely been clarified, this morpho-quantitative study was undertaken to better understand the effects of 2 sublethal doses (T1=1 mg/kg and T3.5=3.5 mg/kg) of HgCl(2) in rat proxi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Stacchiotti A,Borsani E,Rodella L,Rezzani R,Bianchi R,Lavazza A

    更新日期:2003-07-01 00:00:00

  • The effects of X-ray irradiation on the proliferation and apoptosis of MCF-7 breast cancer cells.

    abstract::To investigate the effects of X-ray irradiation on the proliferation and apoptosis of MCF-7 breast cancer cells; MCF-7 breast cancer cells were irradiated with X-ray. After irradiation, morphological changes and growth inhibition rate of the irradiated cells were observed under an inverted microscope. 3-(4,5-dimethylt...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Li DL,Wei L,Wen XM,Song H,Li Q,Lv JW,Kuang CC,Wei ZZ,Zhang JW

    更新日期:2014-05-01 00:00:00

  • The extracellular space in the edematous human cerebral cortex: an electron microscopic study using cortical biopsies.

    abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Castejon OJ

    更新日期:2009-01-01 00:00:00

  • Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.

    abstract::Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Yalim S,Dağlıoğlu K,Coskun G,Polat S

    更新日期:2018-05-01 00:00:00

  • A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

    abstract::Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,随机对照试验


    authors: Funkhouser WK 3rd,Niethammer M,Carson JL,Burns KA,Knowles MR,Leigh MW,Zariwala MA,Funkhouser WK Jr

    更新日期:2014-08-01 00:00:00

  • Renal giant cytoplasmic inclusions in Chédiak-Higashi syndrome: first ultrastructural demonstration in a human biopsy.

    abstract::This report ultrastructurally illustrates the giant lysosome-related organelles in the various cellular components of a renal biopsy from a 10 year-old female affected by the Chédiak-Higashi syndrome. Albeit similar observations have been made and reported in animal models of the syndrome, to the author's knowledge, t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: de Chadarévian JP

    更新日期:2011-08-01 00:00:00

  • Low-grade spindle cell carcinoma of the kidney.

    abstract::The authors report a renal cell carcinoma composed largely of spindle cells of Fuhrman's nuclear grade II in which the bland appearance of the cells and low mitotic index were reminiscent of a benign or low-grade smooth muscle tumor. Keratin immunostaining was positive, but evidence of epithelial differentiation was o...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Lloreta J,Corominas JM,Munné A,Domínguez D,Bielsa O,Gelabert A,Serrano S

    更新日期:1998-01-01 00:00:00

  • The ultrastructural effects of surgical treatment of hydrosalpinx on the human endometrium: a light and electron microscopic study.

    abstract::Hydrosalpinx is a disease commonly observed in women and characterized by the obstruction which is in the shape of a fluid-filled sac at the distal part of tuba uterina closed to the ovary. In this study, we aimed to obtain endometrial tissue samples from the hydrosalpinx patients, before and after the surgical treatm...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Sapmaz T,Gündoğdu LS,Çetin MT,Ürünsak IF,Polat S

    更新日期:2019-01-01 00:00:00

  • Unusual pigmented vesical lesion in a middle-aged woman.

    abstract::Excess lipofuscin deposition in tissues is a phenomenon observed in normal aging. The amount of lipofuscin in myocardium, liver, skeletal muscle, and adnexal skin structures varies considerably with age and increases in older individuals. In addition, lipofuscin deposition occurs in association with specific, non-age-...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Herrera GA,Turbat-Herrera EA,Lockard VG

    更新日期:1990-11-01 00:00:00

  • Ultrastructural phenotype of "intestinal-type" cells in columnar-lined esophagus.

    abstract::An intestinal-type epithelium is often present at columnar-lined esophagus, gastroesophageal junction or within the so-called short segment Barrett's esophagus, but ultrastructural study failed to detect enterocytes in columnar-lined esophagus. The authors have analyzed the intestinal aspects present in areas of colum...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Sbarbati A,Faccioli N,Ricci F,Merigo F,Benati D,Castaldini G,Cordiano C,Osculati F

    更新日期:2002-03-01 00:00:00

  • Sarcomatous type of malignant mesothelioma.

    abstract::Thirteen malignant mesotheliomas of a sarcomatous type were studied by light microscopy and ten were studied by electron microscopy. The histologic patterns varied from tumor to tumor, often resembling other soft tissue sarcomas. Electron microscopic observation showed most of the tumors to be composed of primitive ce...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Klima M,Bossart MI

    更新日期:1983-06-01 00:00:00

  • Diagnostic significance of mitochondria in four types of renal epithelial neoplasms: an ultrastructural study of 60 tumors.

    abstract::Mitochondrial morphology was studied in 60 renal epithelial neoplasms, including clear cell, papillary, chromophobe cell, and oncocytomas, to see if there are significant differences among the various subtypes. Mitochondria from the nephron tubular system obtained from 36 patients with glomerular diseases served as co...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Erlandson RA,Shek TW,Reuter VE

    更新日期:1997-09-01 00:00:00

  • Intercellular junction formation between polymorphonuclear leukocytes, and between polymorphonuclear leukocytes and tumor cells.

    abstract::Morphologic evidence of intercellular junctions was found between polymorphonuclear leukocytes (PMNs) and between PMNs and tumor cells. All these junctions displayed electron-dense plaques along the plasma membranes with linear spaces in between. These plaques were finely granular and devoid of filaments. Fine granule...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Tang CK

    更新日期:1983-09-01 00:00:00