Inflammatory fibroid polyp of the small intestine: ultrastructural and immunohistochemical observations.

Abstract:

:The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histiocytic features, with abundant rough endoplasmic reticulum and active production of collagen in many of the cells and long, dendritic cytoplasmic projections with large cytoplasmic vacuoles containing remnants of phagocytosed cellular debris in others. Immunohistochemical studies showed strong cytoplasmic positivity in the proliferating cells with vimentin antibodies and scattered positivity with muramidase. Additional findings include the ultrastructural demonstration of oligocilia and occasional primitive intercellular junctions. The findings in this case suggest that IFP may represent a proliferation of primitive submucosal stromal cells exhibiting incomplete fibrohistiocytic differentiation.

journal_name

Ultrastruct Pathol

authors

Suster S,Robinson MJ

doi

10.1080/01913129009025123

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

109-19

issue

2

eissn

0191-3123

issn

1521-0758

journal_volume

14

pub_type

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