Abstract:
:Excessive consumption of carbohydrate and fat increases the risk of liver disease. We hypothesized that swim exercise can protect hepatocytes from ultra-structural damage induced by high cholesterol and fructose diets (HCFD). Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks before being sacrificed. Swim exercise trained rats started the treatment from the 11th week until the sacrifice day, end of week 15. Blood samples were assayed for biomarkers of liver injury and adiponectin. The harvested liver tissues were examined using transmission electron microscopy (TEM). TEM images revealed substantial damage and accumulation of lipid droplets (steatosis) in the hepatocytes of the model group that was inhibited by swim exercise. In addition, HCFD significantly (p < 0.0005) increased insulin resistance index (HOMA-IR), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), which were effectively (p < 0.02) decreased by a swim exercise to levels comparable to control group. Whereas, swim exercise increased adiponectin levels in HCFD group (p < 0.03). These results show that HCFD-induced hepatic injury is ameliorated by swim training exercise possibly via restoration of a normal blood sugar and lipid, induction of adiponectin and inhibition of inflammatory, and liver injury biomarkers.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Dallak MA,Bin-Jaliah I,Albawardi A,Haidara MA,Sakr HF,Eid RA,Hassan WN,Al-Ani Bdoi
10.1080/01913123.2017.1422581subject
Has Abstractpub_date
2018-03-01 00:00:00pages
155-161issue
2eissn
0191-3123issn
1521-0758journal_volume
42pub_type
杂志文章abstract::Three young children with characteristic fibroblastic tumors are presented. These comprised one case each of congenital fibrosarcoma, dermatofibrosarcoma protuberans, and fibrous hamartoma of infancy. Ultrastructural examination in each tumor revealed the presence of a peculiar intracisternal paracrystalline material ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128909048494
更新日期:1989-07-01 00:00:00
abstract::A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been speculated eventually to contain atrial natriuretic factor (ANF). The p...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409016293
更新日期:1994-01-01 00:00:00
abstract::Hydrogen sulfide (H2S) and other volatile sulfur compounds (VSCs) appear mainly in the oral air of patients with halitosis. It seems that VSCs are directly involved in the pathogenesis of gingival diseases. In previous studies, short-term (7 hours-4 days), high concentrations (5-400 ppm) of H2S applications on periodo...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2016.1234530
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abstract::This study was aimed at identifying ultrastructural abnormalities that may be present in the duodenum of patients with chronic renal failure who were undergoing hemodialysis and that may have an effect on the normal absorptive function of the duodenum. Duodenal biopsy specimens from ten patients and four controls were...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129009050868
更新日期:1990-01-01 00:00:00
abstract::An intestinal-type epithelium is often present at columnar-lined esophagus, gastroesophageal junction or within the so-called short segment Barrett's esophagus, but ultrastructural study failed to detect enterocytes in columnar-lined esophagus. The authors have analyzed the intestinal aspects present in areas of colum...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120252959281
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abstract::Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of mic...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120590951257
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abstract::Strabismus is an ocular disorder characterized by partial or complete inability to keep eye alignment. It represents a very common ocular problem at ophthalmology clinics worldwide. The current study aimed to show the most encountered ultrastructural changes in extraocular muscles (EOMs) collected from patients with d...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913123.2019.1671927
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abstract::A technique for immunoelectron microscopy is described whereby tissue is embedded in large (6 x 12 mm) plastic blocks and reembedded ("popped off") directly from semithin (3-microns) sections for thin sectioning. This technique is particularly useful in locating relatively sparse cells or tissue structures. Three acry...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209074550
更新日期:1992-01-01 00:00:00
abstract::The objective of this study was to investigate the ultrastructural characteristics of hybrid acute leukemia (HAL). Fifteen cases of HAL were studied by transmission electron microscopy (TEM), focusing on organelles and myeloperoxidase (MPO) reaction of leukemic cells. By TEM, 5 out 15 cases of HAL were consistent with...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131290968722
更新日期:2005-09-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 临床试验,杂志文章
doi:10.3109/01913129609016349
更新日期:1996-09-01 00:00:00
abstract::The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic acid albumin dextrose catalase (OADC) enrichment and at different temperatures: 30, 37 and 42 °C. Four hundred mycobacter...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.950780
更新日期:2015-02-01 00:00:00
abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902787076
更新日期:2009-01-01 00:00:00
abstract::The purpose of this article has been to illustrate the applications and limitations of comparing the ultrastructural morphology of certain poorly differentiated neoplasms with normal human embryonic tissues. The examples used--embryonal rhabdomyosarcoma, Wilms' tumor, and fibrous mesothelioma, in comparison with embry...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128709048450
更新日期:1987-01-01 00:00:00
abstract::Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive lymphoma derived from plasmacytoid dendritic cells or precursor dendritic cells. Despite some 240 reported cases, its morphology and especially ultrastructure has not been satisfactorily studied. A case is reported of a 13 year old boy, who, des...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.813998
更新日期:2014-02-01 00:00:00
abstract::A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120490475707
更新日期:2004-05-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.1080/01913120600932594
更新日期:2006-11-01 00:00:00
abstract::Myoepithelial cells of salivary gland are uniquely specialized cells; their function is unclear, but the considerable complement of muscle-specific actin suggests contractility is one function. By routine transmission electron microscopy myofilament visualization is variable. Some myoepithelial cells appear to have li...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129209061547
更新日期:1992-09-01 00:00:00
abstract::Tissue biopsies and peripheral blood samples from 10 patients with the characteristic clinical features of acquired immunodeficiency syndrome (AIDS) were examined by electron microscopy and ultracytochemical myeloperoxidase technique. Abundant tubuloreticular inclusions (TRI) were detected within the endoplasmic retic...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140585
更新日期:1983-06-01 00:00:00
abstract::Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to f...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500323456
更新日期:2005-11-01 00:00:00
abstract::Thirteen malignant mesotheliomas of a sarcomatous type were studied by light microscopy and ten were studied by electron microscopy. The histologic patterns varied from tumor to tumor, often resembling other soft tissue sarcomas. Electron microscopic observation showed most of the tumors to be composed of primitive ce...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140587
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abstract::Immunogold ultrastructural localization of chromogranin A in secretory granules within tumor cells provides convincing evidence of endocrine or neuroendocrine differentiation. A modified immunogold method (designed for use on osmicated tissue) produced positive labeling of small granules not only in well-differentiate...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129309015402
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128309140784
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abstract::Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules devel...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120500482013
更新日期:2006-01-01 00:00:00
abstract::Six intradermal melanocytic nevi, two with and four without intercellular slitlike spaces, were examined by light microscopy and electron microscopy of deparaffinized tissue. The spaces were partially lined by elongated nevus cells and contained a few collagen fibrils. Other features in both groups included an abundan...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128009141438
更新日期:1980-07-01 00:00:00
abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...
journal_title:Ultrastructural pathology
pub_type: 杂志文章,评审
doi:10.3109/01913123.2013.810690
更新日期:2013-10-01 00:00:00
abstract::Clear-cell carcinomas of the female genital tract are uncommon tumors that usually arise in the ovary, cervix, or vagina. The objectives of the present study were to examine the immunohistochemical and ultrastructural characteristics of 18 of these tumors and to determine whether any distinctive features were present ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016357
更新日期:1996-11-01 00:00:00
abstract::A case of renal angiomyolipoma with regional lymph node involvement is added to 20 cases previously reported. This represents the 11th case reported in a non-tuberous sclerosis patient. The electron microscopic features of the tumor are discussed and correlated with the light microscopic findings. ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129109016260
更新日期:1991-07-01 00:00:00
abstract::The ultrastructural characteristics useful in identifying a selected series of histologically difficult to diagnose malignant neoplasms of the human gynecological sphere are presented. The results are discussed in relation to routine diagnosis and when appropriate, to their pathogenic origin. ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128709048330
更新日期:1987-01-01 00:00:00
abstract::A slowly growing tumor in the right shoulder of a 38-year-old white male, which felt like a superficial cystic mass, was studied. The spindle cells, which represented the main component of the tumor, were arranged in a typical storiform pattern and were positive for CD34 and focally for CD117. The pigmented cells were...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120309935
更新日期:2003-05-01 00:00:00
abstract::Two problematic spindle cell sarcomas involving upper jawbones in two adult male patients have been studied by histology, immunohistochemistry, and transmission electron microscopy, and respectively graded as low-grade malignancy and high-grade malignancy. While any single methodological study did not allow confident ...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131201317101261
更新日期:2001-09-01 00:00:00