Immunogold detection of chromogranin A in the neuroendocrine tumor.

Abstract:

:Immunogold ultrastructural localization of chromogranin A in secretory granules within tumor cells provides convincing evidence of endocrine or neuroendocrine differentiation. A modified immunogold method (designed for use on osmicated tissue) produced positive labeling of small granules not only in well-differentiated tumors but also in poorly differentiated small cell tumors primary in lung, cervix, and skin; only a proportion of granules in some of the tumor cells were positively labeled. Many non-small cell lung tumors often stain focally positive for chromogranin A at the light microscopy level, and such tumors may also contain sparse, small, dense granules. Because positive labeling could not be demonstrated over small granules in non-small cell lung tumors, the theory that such tumors are neuroendocrine in type may be erroneous.

journal_name

Ultrastruct Pathol

authors

Silver MM,Lines LD,Hearn SS

doi

10.3109/01913129309015402

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

83-92

issue

1

eissn

0191-3123

issn

1521-0758

journal_volume

17

pub_type

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