Pulmonary blastomas of childhood: histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations.

Abstract:

:Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to frequent relapses and metastases. The histological, immunohistochemical, and ultrastructural aspects of a personal series of 6 cases of pulmonary blastoma are described and the differences between childhood and adult types are stressed. Due to the aggressiveness of these rare tumors, therapeutic management is quite difficult. The expression of the transmembrane tyrosin kinase receptor c-kit in all the solid cases of this series leads the authors to hypothesize new possible therapeutic implications for these tumors.

journal_name

Ultrastruct Pathol

authors

Boldrini R,Devito R,Diomedi-Camassei F,Francalanci P,Inserra A,Boglino C,Donfrancesco A,Jenkner A,Callea F

doi

10.1080/01913120500323456

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

493-501

issue

6

eissn

0191-3123

issn

1521-0758

pii

R51321J16295331V

journal_volume

29

pub_type

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