Myofibrosarcoma of the upper jawbones: a clinicopathologic and ultrastructural study of two cases.

Abstract:

:Two problematic spindle cell sarcomas involving upper jawbones in two adult male patients have been studied by histology, immunohistochemistry, and transmission electron microscopy, and respectively graded as low-grade malignancy and high-grade malignancy. While any single methodological study did not allow confident classification of them into one or other of the classical categories of spindle cell sarcomas (fibrosarcoma versus leiomyosarcoma), the overall contribution from all three methodologies ultimately allowed them to be categorized as sarcomas with myofibroblastic differentiation. Histologically, both tumors had morphological features of an amalgama between neoplastic fibroblasts and smooth muscle cells. Immunohistochemically, both tumors expressed reactivity only for muscle specific actin and alpha smooth muscle actin, in addition to vimentin. Ultrastructurally, both tumors, while showing fibroblast-like cytoplasmic features, had a spurious and imperfectly organized cell surface defying convincing classification into any of specific categories (i.e., both appeared in terms of ultrastructure as poorly differentiated sarcoma, the former with low level of smooth muscle differentiation and possibly the presence of some fibronexus component, the latter with no smooth muscle differentiation but with possible evidence of very rare fibronectin fibril). Therefore, on balance, the most tenable diagnosis seemed to us that of a myofibrosarcoma in both cases. This work is presented considering the fact that myofibrosarcoma currently represents a topical theme of debate, and that this is the first report in medical literature concerning with myofibrosarcomas of the head and neck area in adults.

journal_name

Ultrastruct Pathol

authors

Bisceglia M,Tricarico N,Minenna P,Magro G,Pasquinelli G

doi

10.1080/019131201317101261

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

385-97

issue

5

eissn

0191-3123

issn

1521-0758

journal_volume

25

pub_type

杂志文章
  • Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy.

    abstract::Lymphoma diagnosis rarely needs electron microscopy (EM), but one area where it can be useful is in the distinction of cytokeratin-positive lymphoma from carcinoma. The authors describe such a case, where difficulties were encountered due to lack of antibody specificity, distinguishing reactive from tumoral cells, and...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802625830

    authors: Eyden B,Chakrabarty B,Hatimy U

    更新日期:2009-01-01 00:00:00

  • Confocal laser scanning microscopy of liesegang rings in odontogenic cysts: analysis of three-dimensional image reconstruction.

    abstract::Liesegang rings are concentric noncellular lamellar structures, occasionally found in inflammatory tissues. They have been confused with various parasites, algas, calcification, and psammoma bodies. The authors examined Liesegang rings from oral inflammatory cysts by both optical and confocal laser scanning microscopy...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120902751288

    authors: Scivetti M,Lucchese A,Crincoli V,Pilolli GP,Favia G

    更新日期:2009-03-01 00:00:00

  • Ultrastructure of poorly differentiated diffuse epithelial mesotheliomas.

    abstract::In differentiating diffuse epithelial mesothelioma from metastatic adenocarcinoma in pleural and peritoneal biopsies, the number and form of microvilli and the amount and distribution of tonofilaments are thought to be the most useful criteria. This report details 5 cases of diffuse epithelial mesothelioma in which th...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141472

    authors: Dardick I,Al-Jabi M,McCaughey WT,Srigley JR,van Nostrand AW,Ritchie AC

    更新日期:1984-01-01 00:00:00

  • Sclerosing stromal tumor of the ovary: an ultrastructural and immunohistochemical analysis with histogenetic considerations.

    abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209061364

    authors: Shaw JA,Dabbs DJ,Geisinger KR

    更新日期:1992-05-01 00:00:00

  • Ultrastructure of an endometrial stromal nodule with skeletal muscle.

    abstract::The ultrastructural appearance of an endometrial stromal nodule with prominent smooth and skeletal muscle differentiation is described. This is the first reported case of endometrial stromal nodule with a heterologous skeletal muscle component and emphasizes the value of electron microscopy and its correlation with im...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129309027783

    authors: Lloreta J,Prat J

    更新日期:1993-05-01 00:00:00

  • Pathology of rotavirus infection in suckling mice: A study by conventional histology, immunofluorescence, ultrathin sections, and scanning electron microscopy.

    abstract::Pathologic changes induced in the small intestine of suckling mice by rotavirus infection were studied by conventional histology, immunofluorescence, scanning electron microscopy, and electron microscopy of ultrathin sections. Infection could be detected within 24 hours in a few mice, but after 2 days it was well esta...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128109031504

    authors: Coelho KI,Bryden AS,Hall C,Flewett TH

    更新日期:1981-01-01 00:00:00

  • Ultrastructural myopathology in the molecular era.

    abstract::Electron microscopy is an essential component of myopathology, both in diagnostics and research of neuromuscular diseases. Although recently reduced in the diagnostic armamentarium, it has greatly been expanded to mouse models in research. Mostly it is descriptive, but a few additional techniques in combination with t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913123.2013.810690

    authors: Goebel HH,Stenzel W

    更新日期:2013-10-01 00:00:00

  • As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope.

    abstract::As You Like It, Part 3, is a continuation of the lectures given by the author (Ultra Path VIII and Ultra Path IX). It is a critical historical review of topics of interest to electron microscopists, attempting to show what went wrong and perhaps also why. The topics chosen this time demonstrate the prominent role elec...

    journal_title:Ultrastructural pathology

    pub_type: 历史文章,杂志文章,评审

    doi:10.1080/019131201300343874

    authors: Ghadially FN

    更新日期:2001-05-01 00:00:00

  • Distinguishing B and T lymphocytes by scanning electron microscopy.

    abstract::This work demonstrates differences between B lymphocytes and T lymphocytes as seen in the scanning electron microscope (SEM). Slides of routinely prepared benign and malignant lymphoid tissues were viewed in the SEM. The location of prominent populations of T lymphocytes and B lymphocytes was verified by immunocytoche...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120050176653

    authors: Terzakis JA

    更新日期:2000-07-01 00:00:00

  • Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines.

    abstract::Canova is an immunomodulatory, homeopathic preparation that has been shown to activate macrophages in vitro and in vivo, with resultant enhanced spreading of the cells and formation of microvillus extensions from the cell body. Since monocytes are the precursor cells of macrophages and dendritic cells, the objective o...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802062729

    authors: Smit E,Pretorius E,Anderson R,Oommen J,Potjo M

    更新日期:2008-07-01 00:00:00

  • Scanning Electron Microscope Characterization of Erosive Enamel in Human Teeth.

    abstract::This study aimed to examine the surface characteristics of erosive enamel in extracted human teeth by scanning electron microscopy. Morphologic changes in naturally eroded enamel depend on the stages of dental erosion. In its early stages, the enamel surfaces show a honeycomb appearance due to the dissolution of ename...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2015.1054014

    authors: Worawongvasu R

    更新日期:2015-01-01 00:00:00

  • An ultrastructural and immunohistochemical study of elastofibroma: CD 34, MEF-2, prominin 2 (CD133), and factor XIIIa-positive proliferating fibroblastic stromal cells connected by Cx43-type gap junctions.

    abstract::Elastofibromas have been described as ill-defined tumors, composed of fibroblastic stromal cells and a dense collagenous stroma. A total of 5 elastofibromas from 4 Japanese patients were examined by ultrastructural and immunohistochemical methods. The proliferating fibroblastic stromal cells in the lesion showed Cx43-...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120701350365

    authors: Yamazaki K

    更新日期:2007-05-01 00:00:00

  • Large block embedding and "pop-off" technique for immunoelectron microscopy.

    abstract::A technique for immunoelectron microscopy is described whereby tissue is embedded in large (6 x 12 mm) plastic blocks and reembedded ("popped off") directly from semithin (3-microns) sections for thin sectioning. This technique is particularly useful in locating relatively sparse cells or tissue structures. Three acry...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209074550

    authors: de Mesy Jensen KL,di Sant'Agnese PA

    更新日期:1992-01-01 00:00:00

  • Overview article: biostructure of blood platelets.

    abstract::Advances in biochemistry, physiology, immunology, and cytochemistry, combined with a variety of new approaches for the evaluation of fine structure, have yielded new insights into the structural physiology and pathology of blood platelets. Subpopulations of platelet granules have been clearly defined; they include the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913128009140561

    authors: White JG,Clawson CC

    更新日期:1980-10-01 00:00:00

  • Sarcomatoid renal cell carcinoma metastatic to the heart: report of a case.

    abstract::An unusual case of metastatic sarcomatoid renal cell carcinoma is presented. Fifteen months after nephrectomy for a typical clear cell carcinoma, a 63-year-old man presented with bilateral pleural effusions, cardiomegaly, and tamponade. A pericardial biopsy showed an anaplastic spindle cell tumor that was strongly ker...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129109016245

    authors: Bird DJ,Semple JP,Seiler MW

    更新日期:1991-07-01 00:00:00

  • Neuronal ceroid lipofuscinosis: an ultrastructural, genetic, and clinical study report.

    abstract::The term "neuronal ceroid lipofuscinosis" (NCL) describes a complex of inherited neurodegenerative conditions associated with storage of lipopigments in brain tissue. In 1989 Dyken proposed a classification of NCL based on the age, clinical symptoms, and ultrastructural aspects of the lipopigments. At the ultrastructu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131201300004681

    authors: Boldrini R,Biselli R,Santorelli FM,Bosman C

    更新日期:2001-01-01 00:00:00

  • Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.

    abstract::Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2018.1463337

    authors: Yalim S,Dağlıoğlu K,Coskun G,Polat S

    更新日期:2018-05-01 00:00:00

  • Diagnostic electron microscopy on reembedded ("popped off") areas of large Spurr epoxy sections.

    abstract::A technique is described in which areas of large Spurr epoxy thick sections are directly popped off of glass slides by inverted Beem capsules filled with polymerized plastic. This technique allows the survey of large regions of tissue with the maintenance of tissue relationships and the selection of specific areas for...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409018580

    authors: di Sant'Agnese PA,De Mesy-Jensen KL

    更新日期:1984-01-01 00:00:00

  • Paraproteinemic crystalloidal keratopathy: an ultrastructural study of two cases, including immunoelectron microscopy.

    abstract::The ultrastructural appearances of corneal crystalloidal deposits are described in two patients with an IgG-kappa paraproteinemia of uncertain pathogenesis. The crystalloids in one patient were overwhelmingly intracellular and were found mainly in stromal keratocytes, but also in basal corneal epithelial cells and the...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913129309027800

    authors: Henderson DW,Stirling JW,Lipsett J,Rozenbilds MA,Roberts-Thomson PJ,Coster DJ

    更新日期:1993-11-01 00:00:00

  • Sellar glomangioma.

    abstract::A glomangioma (glomus tumor) arising in the pituitary region is described. The histologic and ultrastructural features were characteristic. The tumor was composed of epithelioid cells arranged in an organoid fashion around vascular channels and contained scattered mast cells. Electron microscopy revealed tumor cells t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141853

    authors: Asa SL,Kovacs K,Horvath E,Ezrin C,Weiss MH

    更新日期:1984-01-01 00:00:00

  • Ultrastructural examination of renal tubular epithelial cells and hepatocytes in the course of chronic cyclosporin A treatment--a possible link to oxidative stress.

    abstract::Cyclosporin A is an immunosuppressant drug used to prevent graft rejection in organ transplantation. Side effects include toxicity to the kidney and liver. Recently, many experimental and clinical data have demonstrated that CsA-induced toxicity is associated with increased production of reactive oxygen species (ROS) ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.810686

    authors: Korolczuk A,Maciejewski M,Czechowska Md Phd G,Orzeł-Pankowska M

    更新日期:2013-10-01 00:00:00

  • Rapid ultrasonic bath processing for electron microscopy.

    abstract::A new rapid method for the processing of biopsy specimens for electron microscopy is described. The method uses standard reagents and media and employs ultrasonic cleaning bath agitation to accelerate fluid exchange. The procedure takes approximately 2.5 h from specimen excision to polymerized block and gives excellen...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129109021307

    authors: Robb IA,Carpenter BF,Jimenez CL

    更新日期:1991-01-01 00:00:00

  • Dermal Langerhans' cell tumor in chronic myelomonocytic leukemia.

    abstract::Disseminated dermal tumors in a 71-year-old male represented the first clinical manifestation of a chronic myelomonocytic leukemia. The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for S-100 pr...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809058219

    authors: Kaiserling E,Horny HP

    更新日期:1988-03-01 00:00:00

  • The extracellular space in the edematous human cerebral cortex: an electron microscopic study using cortical biopsies.

    abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120902787076

    authors: Castejon OJ

    更新日期:2009-01-01 00:00:00

  • CD44s and CD44v6 in diagnosis and prognosis of human bladder cancer.

    abstract:UNLABELLED:The cell adhesion molecules (CAMs) CD44 standard (CD44s) and its variant 6 (CD44v6) are involved in the progression and invasion of human malignancies. However, discrepancies in the prognostic value of CD44s and CD44v6 expression need to be addressed. AIMS:To investigate the expression of CD44s and CD44v6 i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2011.651522

    authors: Omran OM,Ata HS

    更新日期:2012-05-01 00:00:00

  • Comparison of the myotoxic effects of levobupivacaine, bupivacaine, and ropivacaine: an electron microscopic study.

    abstract::The aim of this study was to investigate the myotoxic effects of bupivacaine, ropivacaine, and levobupivacaine which were applied intramuscularly to rat skeletal muscle. Forty Wistar-Albino rats were divided into four groups. In the study, .5% bupivacaine (Group B), .5% ropivacaine (Group R), .5% levobupivacaine (Grou...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2015.1014610

    authors: Öz Gergin Ö,Yıldız K,Bayram A,Sencar L,Coşkun G,Yay A,Biçer C,Özdamar S,Polat S

    更新日期:2015-05-01 00:00:00

  • 5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas.

    abstract::Aberrant transcription of the FHIT gene has been observed in many solid tumors, suggesting that 5'-CpG island methylation of the FHIT gene is involved in tumor development. The authors investigated the status of the 5'-CpG island methylation of the FHIT gene and protein expression in a series of 40 cervical carcinomas...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120390250329

    authors: Wu Q,Shi H,Suo Z,Nesland JM

    更新日期:2003-11-01 00:00:00

  • Early ultrastructural changes in the central nervous system in Fukuyama congenital muscular dystrophy.

    abstract::Electron microscopy of the central nervous system surface structure is described in two fetuses with Fukuyama congenital muscular dystrophy (FCMD). In addition to relatively large surface defects, many minute defects less than several micrometers in size associated with protrusion of glial cytoplasm were observed in t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709021933

    authors: Yamamoto T,Shibata N,Kanazawa M,Kobayashi M,Komori T,Kondo E,Saito K,Osawa M

    更新日期:1997-07-01 00:00:00

  • Enhancement of intracellular delivery of anti-cancer drugs by the Tat peptide.

    abstract::The arginine-rich cationic Tat peptides have been reported to enhance the intracellular delivery of macromolecules, including DNA, RNA, and proteins. In this work an arginine cationic peptide derived from the HIV-1 Tat protein was conjugated with noncovalent bonds to sulfonated aluminum phthalocyanine (AlPcS, a photos...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2011.557522

    authors: Zhao JF,Chen JY,Mi L,Wang PN,Peng Q

    更新日期:2011-05-01 00:00:00

  • Plasticity of mesangial cells: a basis for understanding pathological alterations.

    abstract::In the last two decades, the ability of mesangial cells to respond to various stimuli or injurious agents by altering their phenotype and function has become recognized. The plasticity of these mesangial cells has been linked to the morphological and functional alterations responsible for the pathologic findings. Many...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01913120600932594

    authors: Herrera GA

    更新日期:2006-11-01 00:00:00