Actin cytoskeleton reorganization correlates with cofilin nuclear expression and ultrastructural changes in cho aa8 cell line after apoptosis and mitotic catastrophe induction by doxorubicin.


:The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed some entirely characteristic features together with overlapping elements of other types of cell death. Additionally, the authors suggest that, as defined here, reorganization of F-actin might be involved in all cell death processes. Changes in the nuclear expression of cofilin are related to F-actin cytoplasm-nuclear translocation and its intranuclear dynamic reorganization.


Ultrastruct Pathol


Grzanka D,Marszałek A,Izdebska M,Gackowska L,Andrzej Szczepanski M,Grzanka A




Has Abstract


2011-05-01 00:00:00












  • Light microscopic and ultrastructural evidence of in vivo phagocytosis of Helicobacter pylori by neutrophils.

    abstract::Helicobacter pylori is believed to cause chronic active gastritis. Infection/colonization of the gastric mucosal surface induces a mucosal inflammatory reaction in the form of lymphocytic aggregates, plasma cells and, particularly, neutrophils, which may, in turn, damage the mucosal epithelium. In vitro studies demons...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Zu Y,Cassai ND,Sidhu GS

    更新日期:2000-09-01 00:00:00

  • Ultrastructural study of a perineurioma.

    abstract::A case of soft tissue tumor in the left brachialis muscle of a 49-year-old Japanese female patient was studied by electron microscopy. The tumor was diagnosed as intramuscular myxoma by light microscopy, but electron microscopic observation revealed that the tumor almost entirely consisted of cells similar to normal p...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审


    authors: Ohno T,Park P,Akai M,Kamura S,Murase K,Kimura H,Kadoya H,Manabe S,Nagao K,Sugano I

    更新日期:1988-09-01 00:00:00

  • Ultrastructural changes in epithelial cells of rats exposed to low concentration of hydrogen sulfide for 50 days.

    abstract::Hydrogen sulfide (H2S) and other volatile sulfur compounds (VSCs) appear mainly in the oral air of patients with halitosis. It seems that VSCs are directly involved in the pathogenesis of gingival diseases. In previous studies, short-term (7 hours-4 days), high concentrations (5-400 ppm) of H2S applications on periodo...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Yalçın Yeler D,Aydın M,Hocaoğlu PT,Koraltan M,Özdemir H,Kotil T,Gül M

    更新日期:2016-11-01 00:00:00

  • Sclerosing stromal tumor of the ovary: an ultrastructural and immunohistochemical analysis with histogenetic considerations.

    abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Shaw JA,Dabbs DJ,Geisinger KR

    更新日期:1992-05-01 00:00:00

  • Astroblastoma: ultrastructural observations on a case of high-grade type.

    abstract::An astroblastoma of high-grade type arising in the brain of a 3-year-old child is reported. The first description of the ultrastructural, immunohistochemical, and cytogenetic findings in this rare tumor variant are presented. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Mierau GW,Tyson RW,McGavran L,Parker NB,Partington MD

    更新日期:1999-09-01 00:00:00

  • Tannic acid binding of cell surfaces in normal, premalignant, and malignant squamous epithelium of the human uterine cervix.

    abstract::Alterations in tannic acid (TA) binding capacity of cell surface carbohydrates in normal, premalignant, and malignant squamous epithelium of the human uterine cervix have been studied using electron microscopic visualization in combination with microdensitometric evaluation. While in normal epithelium there is distinc...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Davina JH,Lamers GE,van Haelst UJ,Kenemans P,Stadhouders AM

    更新日期:1984-01-01 00:00:00

  • Detection of villous conidia of Conidiobolus coronatus in a blood sample by scanning electron microscopy investigation.

    abstract::Conidiobolus coronatus is a major insect pathogen belonging to the fungal order Entomophthorales, causing a rare subcutaneous infection of the nasofacial region, resulting in swelling of predominantly the nose, mouth, and perinasal tissue. Later in the course of the infection firm, painless, subcutaneous nodules devel...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Hoogendijk CF,Pretorius E,Marx J,Van Heerden WE,Imhof A,Schneemann M

    更新日期:2006-01-01 00:00:00

  • Epithelioid variant of pleomorphic liposarcoma: a comparative immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelial malignancies.

    abstract::Pleomorphic liposarcoma (PL) is the least common subtype of liposarcoma, displaying a lipoblastic, malignant fibrous histiocytoma (MFH)-like and, less frequently, an epithelioid growth pattern. The epithelioid morphology in PL is still underrecognized and may closely simulate other epithelial neoplasms, mainly adrenal...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Huang HY,Antonescu CR

    更新日期:2002-09-01 00:00:00

  • Subacute inflammatory polyneuropathy: two cases with plasmacytoid histiocytes in the endoneurium.

    abstract::Inflammatory polyneuropathies are mainly known by their acute form, Guillain-Barré syndrome, but there are also chronic cases and all are considered as having an autoimmune mechanism. In each form, peripheral nerve biopsies show scattered macrophages in the endoneurium and in certain cases macrophages invade the Schwa...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Vital C,Vital A,Lagueny A,Larribau E,Saintarailles J,Julien J

    更新日期:1998-09-01 00:00:00

  • Myofibrosarcoma of the upper jawbones: a clinicopathologic and ultrastructural study of two cases.

    abstract::Two problematic spindle cell sarcomas involving upper jawbones in two adult male patients have been studied by histology, immunohistochemistry, and transmission electron microscopy, and respectively graded as low-grade malignancy and high-grade malignancy. While any single methodological study did not allow confident ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Bisceglia M,Tricarico N,Minenna P,Magro G,Pasquinelli G

    更新日期:2001-09-01 00:00:00

  • Swim exercise training ameliorates hepatocyte ultrastructural alterations in rats fed on a high fat and sugar diet.

    abstract::Excessive consumption of carbohydrate and fat increases the risk of liver disease. We hypothesized that swim exercise can protect hepatocytes from ultra-structural damage induced by high cholesterol and fructose diets (HCFD). Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) fo...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Dallak MA,Bin-Jaliah I,Albawardi A,Haidara MA,Sakr HF,Eid RA,Hassan WN,Al-Ani B

    更新日期:2018-03-01 00:00:00

  • Ultrastructural morphologic changes in mycobacterial biofilm in different extreme condition.

    abstract::The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic acid albumin dextrose catalase (OADC) enrichment and at different temperatures: 30, 37 and 42 °C. Four hundred mycobacter...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Kumar V,Sachan TK,Sharma P,Rawat KD

    更新日期:2015-02-01 00:00:00

  • Malignant meningioma of the parapharyngeal space: a case report.

    abstract::A case of a malignant meningioma arising in the left parapharyngeal space in a 29-year-old woman is reported. Electron microscopic examination of the tumor was critical in establishing the diagnosis. Meningiomas of the parapharyngeal space are extremely rare. This constitutes the first malignant case documented in thi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Dominguez-Malagon H,Ordóñez NG

    更新日期:1996-01-01 00:00:00

  • Intercellular communication by extracellular vesicles with emphasis on the roles of cordocytes in the human brain. An ultrastructural study.

    abstract::We describe in this work the presence of extracellular vesicles (EVs) along different cell types, especially cordocytes, in various clinical conditions of the human brain (atherothrombotic disease, cerebral tumors, hygroma durae matris, intracerebral cysts, Moyamoya disease and parenchymatous hematoma) using transmiss...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Pais V,Pais ES

    更新日期:2015-05-01 00:00:00

  • Monoclonal glomerulopathy with features of cryoglobulinemic glomerulopathy in murine multiple myeloma model.

    abstract::In vivo and animal models of monoclonal light chain-associated renal diseases are limited. The Vk*MYC transgenic model with multiple myeloma in 50-70 weeks old mice with renal involvement has been reported before, but detailed renal pathologic changes have not been well documented. This study fully investigated pathol...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Zhang PL,Herrera GA,Liu B

    更新日期:2020-11-20 00:00:00

  • Ultrastructural study across the leprosy spectrum.

    abstract::We have carried out a systematic ultrastructural study of the bacilli, the cell-mediated response in the host, and the dermal microvasculature in lepromatous (LL), borderline lepromatous (BL), and borderline tuberculoid (BT) types of active leprosy (eight cases). In the types of least resistance (LL and BL), macrophag...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Ortega VV,Martínez Díaz F,Ortuño Pacheco G,Calderón Rubiales F

    更新日期:1994-07-01 00:00:00

  • Myoepithelial cells in lobular carcinoma in situ of the breast: a parallel immunocytochemical and ultrastructural study.

    abstract::The distribution and morphology of myoepithelial cells in one case of normal breast and in 4 cases of lobular carcinoma in situ (LCIS) were studed by immunoperoxidase and immunofluorescence with anti-actin antisera and by electron microscopy. The actin-rich cells appeared to lay flattened on the basement membrane, or ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Bussolati G,Botto Micca FB,Eusebi V,Betts CM

    更新日期:1981-07-01 00:00:00

  • Malignant enterochromaffinlike cell carcinoid of the gastric stump: an ultrastructural study.

    abstract::A metastasizing carcinoid of the gastric stump found 25 years after Billroth II gastric resection for duodenal ulcer is described. Electron microscopy and optical endocrine cell staining proved the tumor to be composed of enterochromaffinlike (ECL) cells. This unusual combination further shows that, at variance with m...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: D'Adda T,Azzoni C,Franzé A,Bordi C

    更新日期:1991-05-01 00:00:00

  • Ultrastructural, cytochemical, and immunocytochemical study of nuclei and cytoskeleton of thyroid papillary carcinoma cells.

    abstract::One of the most constant and typical histological markers of thyroid papillary carcinoma is the presence of multilobated and ground-glass nuclei. With the intention of extending and characterizing the ultrastructural comprehension of this feature, thyroid papillary carcinoma cells and normal follicular cells were stud...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Echeverría OM,Hernández-Pando R,Vázquez-Nin GH

    更新日期:1998-05-01 00:00:00

  • Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin.

    abstract::The drugs cisplatin and gentamicin are used for treatment of various cancer patients suffering from infection. The authors report a detailed electron microscopic study of blood vessels in stria vascularis of guinea pigs after treatment with cisplatin alone and in combination with gentamicin. The most distinctive featu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Kohn S,Fradis M,Podoshin L,Ben-David J,Zidan J,Robinson E

    更新日期:1997-05-01 00:00:00

  • The extracellular space in the edematous human cerebral cortex: an electron microscopic study using cortical biopsies.

    abstract::In a vascular anomaly showing moderate edema, the extracellular space appeared apparently normal, exhibiting a membrane to membrane space of about 20 nm in width. In congenital hydrocephalus, this space appeared notably enlarged and occupied by an electron transparent, nonproteinaceous interstitial edema fluid, due to...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Castejon OJ

    更新日期:2009-01-01 00:00:00

  • Intracisternal tubules in human melanoma cells.

    abstract::Aggregates of parallel microtubules have been found within cisternae of the rough endoplasmic reticulum in cells of six human metastatic melanomas. The tubules have a uniform diameter and regular spacing and in longitudinal sections can be seen to possess a fine periodicity. They are compared with tubuloreticular incl...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Mackay B,Ayala AG

    更新日期:1980-01-01 00:00:00

  • Tumor multiplicity is an independent prognostic factor of non-muscle-invasive bladder cancer treated with Bacillus Calmette-Guerin immunotherapy.

    abstract:BACKGROUND:Bacillus Calmette-Guerin (BCG) immunotherapy is regarded as the current treatment of choice for non muscle invasive bladder cancer (NMIBC), though its efficacy is limited by high recurrence and progression rate. Identification of factor prognosticators that might be helpful in discriminating between responde...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Ajili F,Manai M,Darouiche A,Chebil M,Boubaker S

    更新日期:2012-10-01 00:00:00

  • Chromogranin A and vesicular monoamine transporter 2 immunolocalization in protein bodies of human locus coeruleus neurons.

    abstract::Our previous histochemical and ultrastructural studies have identified, in human catecholamine neurons, abundant spherical acidophilic protein bodies (pb), which originate from regular mitochondria, retaining their double membrane. In locus coeruleus (LC) neurons, pb have somatodendritic distribution and are unequivoc...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Kloukina-Pantazidou I,Chrysanthou-Piterou M,Havaki S,Issidorides MR

    更新日期:2013-04-01 00:00:00

  • Gastrointestinal stromal tumor of the stomach with rhabdoid phenotype: immunohistochemical, ultrastructural, and immunoelectron microscopic evaluation.

    abstract::A variety of neoplasms with rhabdoid differentiation have been reported in many sites. The authors describe a case of gastrointestinal stromal tumor (GIST) of the stomach that exhibited prominent rhabdoid features. Immunohistochemically, the tumor cells displayed positive staining for vimentin, c-kit, CD34, and alpha ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Richmond JA,Mount SL,Schwarz JE

    更新日期:2004-05-01 00:00:00

  • Electron microscopy of histologically difficult to diagnose gynecologic neoplasms.

    abstract::The ultrastructural characteristics useful in identifying a selected series of histologically difficult to diagnose malignant neoplasms of the human gynecological sphere are presented. The results are discussed in relation to routine diagnosis and when appropriate, to their pathogenic origin. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Ferenczy A

    更新日期:1987-01-01 00:00:00

  • Abnormal cutaneous nerves in incontinentia pigmenti.

    abstract::Cutaneous nerves showed multiple ultrastructural abnormalities in a patient with incontinentia pigmenti. Fetal nerve bundles were seen both in the dermis and entering the epidermis. A cell with some Schwann cell features was identified above the basal layer amid keratinocytes. Dermal melanophages were in close apposit...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Worret WI,Nordquist RE,Burgdorf WH

    更新日期:1988-01-01 00:00:00

  • Meningeal melanocytoma: a case report and literature review.

    abstract::The clinicopathologic, immunocytochemical, and electron microscopic features of a case of meningeal melanocytoma arising in the phylum terminale are reported. Meningeal melanocytoma is an uncommon tumor that must be distinguished from metastatic or primary malignant melanoma, meningeal melanocytic nevi, pigmented meni...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审


    authors: Alameda F,Lloreta J,Galitó E,Roquer J,Serrano S

    更新日期:1998-07-01 00:00:00

  • Ultrastructural changes to rabbit fibrin and platelets due to aspartame.

    abstract::The coagulation process, including thrombin, fibrin, as well as platelets, plays an important role in hemostasis, contributing to the general well-being of humans. Fibrin formation and platelet activation are delicate processes that are under the control of many small physiological events. Any one of these many proces...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Pretorius E,Humphries P

    更新日期:2007-03-01 00:00:00

  • Ultrastructural changes of extraocular muscles in strabismus patients.

    abstract::Strabismus is an ocular disorder characterized by partial or complete inability to keep eye alignment. It represents a very common ocular problem at ophthalmology clinics worldwide. The current study aimed to show the most encountered ultrastructural changes in extraocular muscles (EOMs) collected from patients with d...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Al-Falki Y,Al-Shraim M,Alsabaani NA,Eid RA,Radad K

    更新日期:2019-01-01 00:00:00