Actin cytoskeleton reorganization correlates with cofilin nuclear expression and ultrastructural changes in cho aa8 cell line after apoptosis and mitotic catastrophe induction by doxorubicin.


:The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed some entirely characteristic features together with overlapping elements of other types of cell death. Additionally, the authors suggest that, as defined here, reorganization of F-actin might be involved in all cell death processes. Changes in the nuclear expression of cofilin are related to F-actin cytoplasm-nuclear translocation and its intranuclear dynamic reorganization.


Ultrastruct Pathol


Grzanka D,Marszałek A,Izdebska M,Gackowska L,Andrzej Szczepanski M,Grzanka A




Has Abstract


2011-05-01 00:00:00












  • Ultrastructural and histochemical study of the motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis.

    abstract::Motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis (ALS) were examined light and electron microscopically. Light microscopically, typical neurogenic changes such as small angulated fibers and grouped atrophy were found in the intrinsic laryngeal muscles. Acetylcholinesterase (AchE) ac...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Yoshihara T,Ishii T,Iwata M,Nomoto M

    更新日期:1998-03-01 00:00:00

  • Tannic acid binding of cell surfaces in normal, premalignant, and malignant squamous epithelium of the human uterine cervix.

    abstract::Alterations in tannic acid (TA) binding capacity of cell surface carbohydrates in normal, premalignant, and malignant squamous epithelium of the human uterine cervix have been studied using electron microscopic visualization in combination with microdensitometric evaluation. While in normal epithelium there is distinc...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Davina JH,Lamers GE,van Haelst UJ,Kenemans P,Stadhouders AM

    更新日期:1984-01-01 00:00:00

  • Endothelial injury of capillaries in the stria vascularis of guinea pigs treated with cisplatin and gentamicin.

    abstract::The drugs cisplatin and gentamicin are used for treatment of various cancer patients suffering from infection. The authors report a detailed electron microscopic study of blood vessels in stria vascularis of guinea pigs after treatment with cisplatin alone and in combination with gentamicin. The most distinctive featu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Kohn S,Fradis M,Podoshin L,Ben-David J,Zidan J,Robinson E

    更新日期:1997-05-01 00:00:00

  • Prolonged storage of fixative for electron microscopy: effects on tissue preservation for diagnostic specimens.

    abstract::Prolonged storage of Karnovsky's fixative, at both 4 and -20 degrees C, is possible in the diagnostic electron microscopy setting. Ultrastructural detail was not compromised in specimens processed in fixative that had been stored for 6 months. Evidence of smooth muscle and neuroendocrine differentiation was present in...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Mount SL,Schwarz JE,Taatjes DJ

    更新日期:1997-03-01 00:00:00

  • Early ultrastructural changes in the central nervous system in Fukuyama congenital muscular dystrophy.

    abstract::Electron microscopy of the central nervous system surface structure is described in two fetuses with Fukuyama congenital muscular dystrophy (FCMD). In addition to relatively large surface defects, many minute defects less than several micrometers in size associated with protrusion of glial cytoplasm were observed in t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Yamamoto T,Shibata N,Kanazawa M,Kobayashi M,Komori T,Kondo E,Saito K,Osawa M

    更新日期:1997-07-01 00:00:00

  • Dose-dependent mercuric chloride tubular injury in rat kidney.

    abstract::Mercuric chloride (HgCl(2)) produces an acute renal failure in experimental animal models. Since the mechanism of tubular injury has not completely been clarified, this morpho-quantitative study was undertaken to better understand the effects of 2 sublethal doses (T1=1 mg/kg and T3.5=3.5 mg/kg) of HgCl(2) in rat proxi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Stacchiotti A,Borsani E,Rodella L,Rezzani R,Bianchi R,Lavazza A

    更新日期:2003-07-01 00:00:00

  • Ultrastructural changes of extraocular muscles in strabismus patients.

    abstract::Strabismus is an ocular disorder characterized by partial or complete inability to keep eye alignment. It represents a very common ocular problem at ophthalmology clinics worldwide. The current study aimed to show the most encountered ultrastructural changes in extraocular muscles (EOMs) collected from patients with d...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Al-Falki Y,Al-Shraim M,Alsabaani NA,Eid RA,Radad K

    更新日期:2019-01-01 00:00:00

  • Extrusion of amyloid fibrils to the extracellular space in experimental mesangial AL-amyloidosis: transmission and scanning electron microscopy studies and correlation with renal biopsy observations.

    abstract::In vitro studies have provided much information regarding the process of glomerular AL-amyloidogenesis. Research efforts have been successful in deciphering how glomerulopathic light chains interact with mesangial cells. The sequential steps involved in the genesis of amyloid fibrils include interactions with surface ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Teng J,Turbat-Herrera EA,Herrera GA

    更新日期:2014-04-01 00:00:00

  • Enhancement of intracellular delivery of anti-cancer drugs by the Tat peptide.

    abstract::The arginine-rich cationic Tat peptides have been reported to enhance the intracellular delivery of macromolecules, including DNA, RNA, and proteins. In this work an arginine cationic peptide derived from the HIV-1 Tat protein was conjugated with noncovalent bonds to sulfonated aluminum phthalocyanine (AlPcS, a photos...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Zhao JF,Chen JY,Mi L,Wang PN,Peng Q

    更新日期:2011-05-01 00:00:00

  • Diagnostic significance of mitochondria in four types of renal epithelial neoplasms: an ultrastructural study of 60 tumors.

    abstract::Mitochondrial morphology was studied in 60 renal epithelial neoplasms, including clear cell, papillary, chromophobe cell, and oncocytomas, to see if there are significant differences among the various subtypes. Mitochondria from the nephron tubular system obtained from 36 patients with glomerular diseases served as co...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Erlandson RA,Shek TW,Reuter VE

    更新日期:1997-09-01 00:00:00

  • Intracisternal paracrystalline serpigenous inclusions: a marker of disordered fibroblastic proliferation.

    abstract::Three young children with characteristic fibroblastic tumors are presented. These comprised one case each of congenital fibrosarcoma, dermatofibrosarcoma protuberans, and fibrous hamartoma of infancy. Ultrastructural examination in each tumor revealed the presence of a peculiar intracisternal paracrystalline material ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Sinclair-Smith CC,Emms M,Mills AE

    更新日期:1989-07-01 00:00:00

  • Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia.

    abstract::A case of lymphoid hyperplasia with prominent plasmacytic proliferation histologically and with polyclonal hypergammaglobulinemia and anemia clinically was reported. This condition in a 54-year-old Japanese male was probably a type of plasma cell dyscrasia similar to a plasma cell variant of Castleman's disease. About...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Mikata A,Suzuki S,Suzuki H,Higo O,Shimoyama M

    更新日期:1984-01-01 00:00:00

  • Renal cell carcinoma metastatic to a pituitary FSH/LH adenoma: case report and review of the literature.

    abstract::Abstract Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastati...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审


    authors: Magnoli F,Finzi G,Riva C,Capella C

    更新日期:2014-12-01 00:00:00

  • Ultrastructure of the blood and lymphatic capillaries of the respiratory tissue during inflammation and endobronchial laser therapy.

    abstract::For wide application of low-energy laser irradiation in the pulmonary clinic, study of the structural basis of the therapeutic effect is necessary. The aim of this research is to describe the structural changes of the blood and lymphatic capillaries in the respiratory tissues during inflammation and following laser bi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Polosukhin VV

    更新日期:2000-05-01 00:00:00

  • As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope.

    abstract::As You Like It, Part 3, is a continuation of the lectures given by the author (Ultra Path VIII and Ultra Path IX). It is a critical historical review of topics of interest to electron microscopists, attempting to show what went wrong and perhaps also why. The topics chosen this time demonstrate the prominent role elec...

    journal_title:Ultrastructural pathology

    pub_type: 历史文章,杂志文章,评审


    authors: Ghadially FN

    更新日期:2001-05-01 00:00:00

  • Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes.

    abstract::The morphology, karyotype, in vitro growth properties, and expression of tyrosine kinase receptors and proto-oncogenes are reported for a newly established large cell undifferentiated lung carcinoma cell line (RVH-6849). The results were analyzed concomitantly with those for two well-established cell lines from an ade...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Wang NS,Liu C,Emond J,Tsao MS

    更新日期:1992-07-01 00:00:00

  • Diagnostic electron microscopy on reembedded ("popped off") areas of large Spurr epoxy sections.

    abstract::A technique is described in which areas of large Spurr epoxy thick sections are directly popped off of glass slides by inverted Beem capsules filled with polymerized plastic. This technique allows the survey of large regions of tissue with the maintenance of tissue relationships and the selection of specific areas for...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: di Sant'Agnese PA,De Mesy-Jensen KL

    更新日期:1984-01-01 00:00:00

  • Multiple wall in-folds sub-divide single segments during capillary regression in hyperoxic acute lung injury.

    abstract::The present study provides further insight into the structural processes that remodel pulmonary capillaries in the injured adult lung. Early in hyperoxia acute lung injury (HALI), many sub-dividing segments are present throughout the capillary network before segment occlusion and loss predominate and capillary density...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Jones RC,Capen DE

    更新日期:2014-05-01 00:00:00

  • Inflammatory fibroid polyp of the small intestine: ultrastructural and immunohistochemical observations.

    abstract::The ultrastructural and immunohistochemical features of a primary tumor of the ileum showing the classic histologic features of an inflammatory fibroid polyp (IFP) of the gastrointestinal tract are presented. Ultrastructurally the proliferating cells showed a combination of fibroblastic and histiocytic features, with ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Suster S,Robinson MJ

    更新日期:1990-03-01 00:00:00

  • Unusual pigmented vesical lesion in a middle-aged woman.

    abstract::Excess lipofuscin deposition in tissues is a phenomenon observed in normal aging. The amount of lipofuscin in myocardium, liver, skeletal muscle, and adnexal skin structures varies considerably with age and increases in older individuals. In addition, lipofuscin deposition occurs in association with specific, non-age-...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Herrera GA,Turbat-Herrera EA,Lockard VG

    更新日期:1990-11-01 00:00:00

  • Protective effect of tetrahydrobiopterin on hepatic and renal damage after acute cadmium exposure in male rats.

    abstract::Cadmium (Cd) has been recognized as one of the most important environmental and industrial pollutants. This study investigated the impact of acute exposure to Cd on oxidative stress and the inflammatory marker interleukin-6 (IL-6) in the plasma of rats and the histological picture of liver and kidney, as well as to ex...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Mostafa DG,Ahmed SF,Hussein OA

    更新日期:2018-11-01 00:00:00

  • Ultrastructural analysis of the Krebs-2 ascites cancer cells treated with extracellular double-stranded DNA preparation.

    abstract::Electron-microscopic analysis of the ultrastructure of the Krebs-2 carcinoma ascites cells in the first 90 min immediately after their exposure to fragmented double-stranded DNA has been performed. Morphological attributes of the treated cancer cells indicate the induction in these cells of destructive processes of pr...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Kirikovich SS,Taranov OS,Omigov VV,Potter EA,Dolgova EV,Proskurina AS,Efremov YR,Bogachev SS

    更新日期:2019-01-01 00:00:00

  • Ultrastructural analysis of the oocytes of female Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) ticks subjected to the action of Azadirachta indica A. Juss (neem).

    abstract::The present study provides ultrastructural information about the acaricidal effects of neem (Azadirachta indica A. Juss) on the ovaries of R. sanguineus engorged females. In general, the main damage caused in the oocytes was alteration in the shape of the cell and of the germinal vesicle, ring-shaped nucleolus, cytopl...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Denardi SE,Bechara GH,de Oliveira PR,Mathias MI

    更新日期:2012-02-01 00:00:00

  • Sclerosing stromal tumor of the ovary: an ultrastructural and immunohistochemical analysis with histogenetic considerations.

    abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Shaw JA,Dabbs DJ,Geisinger KR

    更新日期:1992-05-01 00:00:00

  • Betulinic acid induces apoptosis and ultrastructural changes in MDA-MB-231 breast cancer cells.

    abstract::The aim of this study is to investigate the effects of betulinic acid (BA) on triple-negative breast cancer MDA-MB-231 cells and observe the ultrastructural changes. The concentration of BA required to induce apoptosis in MDA-MB-231 cells has been previously reported. In this study, a cell counting kit-8 proliferation...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Gao Y,Ma Q,Ma YB,Ding L,Xu XL,Wei DF,Wei L,Zhang JW

    更新日期:2018-01-01 00:00:00

  • Plexiform soft tissue tumor composed predominantly of perineurial fibroblasts (perineurioma).

    abstract::A 15-year-old girl presented with a small, indolent mass near the knee joint. Light microscopy revealed a peculiar myxoid plexiform tumor composed of cytologically bland cells. Interpretation of the initial biopsy material was controversial. Subsequent immunohistochemical studies revealed tumor cells to be strongly re...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Weidner N,Nasr A,Johnston J

    更新日期:1993-05-01 00:00:00

  • Granular cell tumor: a review of the pathology and histogenesis.

    abstract::As the name suggests, the histogenesis of the granular cell tumor is uncertain, but this intriguing neoplasm has occasioned much speculation and controversy since its description in 1926 as a myoblastoma. Though ubiquitous in its anatomic location, it is usually small, solitary, benign, and readily recognized by routi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审


    authors: Ordóñez NG,Mackay B

    更新日期:1999-07-01 00:00:00

  • Subacute inflammatory polyneuropathy: two cases with plasmacytoid histiocytes in the endoneurium.

    abstract::Inflammatory polyneuropathies are mainly known by their acute form, Guillain-Barré syndrome, but there are also chronic cases and all are considered as having an autoimmune mechanism. In each form, peripheral nerve biopsies show scattered macrophages in the endoneurium and in certain cases macrophages invade the Schwa...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Vital C,Vital A,Lagueny A,Larribau E,Saintarailles J,Julien J

    更新日期:1998-09-01 00:00:00

  • Renal malakoplakia: report of a case with multifocal involvement.

    abstract::The authors report the light microscopic and ultrastructural features in one case of malakoplakia involving the kidney, the urinary bladder, and the skin. The kidney was excised. Lesions of the urinary bladder and the skin regressed after topical treatment with cholinergic agonists and antimicrobial drugs. This case i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Lloreta J,Cañas MA,Munné A,Arumí M,Bielsa O,Gelabert A,Serrano S

    更新日期:1997-11-01 00:00:00

  • Confocal laser scanning microscopy of liesegang rings in odontogenic cysts: analysis of three-dimensional image reconstruction.

    abstract::Liesegang rings are concentric noncellular lamellar structures, occasionally found in inflammatory tissues. They have been confused with various parasites, algas, calcification, and psammoma bodies. The authors examined Liesegang rings from oral inflammatory cysts by both optical and confocal laser scanning microscopy...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章


    authors: Scivetti M,Lucchese A,Crincoli V,Pilolli GP,Favia G

    更新日期:2009-03-01 00:00:00