Actin cytoskeleton reorganization correlates with cofilin nuclear expression and ultrastructural changes in cho aa8 cell line after apoptosis and mitotic catastrophe induction by doxorubicin.

Abstract:

:The effect of doxorubicin on the expression of cofilin and actin in CHO AA8 cells was estimated by fluorescence and electron microscopy. The presence of cofilin and actin was observed particularly in the nuclei of cells by different modes after treatment by doxorubicin. Cells undergoing mitotic catastrophe expressed some entirely characteristic features together with overlapping elements of other types of cell death. Additionally, the authors suggest that, as defined here, reorganization of F-actin might be involved in all cell death processes. Changes in the nuclear expression of cofilin are related to F-actin cytoplasm-nuclear translocation and its intranuclear dynamic reorganization.

journal_name

Ultrastruct Pathol

authors

Grzanka D,Marszałek A,Izdebska M,Gackowska L,Andrzej Szczepanski M,Grzanka A

doi

10.3109/01913123.2010.548113

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

130-8

issue

3

eissn

0191-3123

issn

1521-0758

journal_volume

35

pub_type

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