Ultrastructural defects of the glomerular basement membranes associated with primary glomerular nephropathies.

Abstract:

:It is generally accepted that a glomerular basement membrane (GBM) thinner than 200 nm should be considered below normal. When this abnormality has a global and diffuse distribution, the associated clinical condition is a benign familial hematuria related to mutations of the COL4A4/COL4A3 genes, or an Alport syndrome. More often the GBM defects display a focal and segmental pattern, too small to express a thin glomerular basement membrane disease. The aim of this study is to emphasize statistical data concerning the pathogenic link between the renal glomerular diseases and the preexisting thin and very thin GBM. A series of 487 renal biopsies from adult patients has been thoroughly investigated both for nephropathologic diagnosis and the GBM ultrastructure. It has been statistically concluded that there is a close coexistence of primary glomerulonephritis and thin glomerular basement membranes with the role of a predisposing condition for immune complex deposition.

journal_name

Ultrastruct Pathol

authors

Mandache E,Gherghiceanu M

doi

10.1080/01913120490445016

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

103-8

issue

2

eissn

0191-3123

issn

1521-0758

pii

E6XULTF030JRPBDY

journal_volume

28

pub_type

杂志文章
  • Phenotype/genotype correlations in the ultrastructure of monogenetic glomerular diseases.

    abstract::Electron microscopy defined classic patterns of hereditary glomerular disease long before genetics revealed an underlying specific mutation. Genetic analysis is now easier to perform in clinical practice but an earlier optimism that genetics would predict disease severity and phenotype is challenged. The classic parad...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/019131290505194

    authors: Liapis H,Foster K,Theodoropoulou E,Monga G,Pizzolitto S,Mazzucco G

    更新日期:2004-07-01 00:00:00

  • Fibrolamellar hepatic tumor with neurosecretory features and systemic deposition of AA amyloid.

    abstract::A 28-year-old man presented with left cervical lymph node metastases and a 7-cm mass in the left lobe of the liver. Biopsy material from both sites revealed a fibrolamellar hepatocarcinoma (FLHC) with immunocytochemical and ultrastructural evidence of neurosecretory differentiation. The patient refused treatment. He d...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129409016302

    authors: Lloreta J,Vadell C,Fabregat X,Serrano S

    更新日期:1994-01-01 00:00:00

  • Primary cilia metaplasia in renal transplant biopsies with acute tubular injury.

    abstract::Primary cilia are hair-like organelles singly distributed along the apical surface of proximal and distal nephron tubules as mechanosensors. The goal of this study was to use electron microscopy to systemically evaluate cilia changes in acute tubular injury (ATI) from both transplant and native renal biopsies. Three g...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.768745

    authors: Hayek S,Parasuraman R,Desai HS,Samarapungavan D,Li W,Wolforth SC,Reddy GH,Cohn SR,Rocher LL,Dumler F,Rooney MT,Zhang PL

    更新日期:2013-05-01 00:00:00

  • Unexpected Fabry disease in a renal allograft kidney: an underrecognized cause of poor allograft function.

    abstract::Fabry disease is an X-linked recessive lysosomal storage disease caused by a deficiency of α-galactosidase A, with characteristic ultrastructural cytoplasmic myelin-like inclusions. Renal lesions are seen in male and variably in heterozygous female patients. One previous report has described Fabry disease involving a ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2010.538136

    authors: Kochar O,Wick MR,Kerr SE,Oglesbee D,Cathro HP

    更新日期:2011-04-01 00:00:00

  • Ultrastructural changes suggestive of focal segmental glomerulosclerosis in atypical minimal change nephrotic syndrome.

    abstract::In an attempt to recognize early stages of focal segmental glomerulosclerosis (FSGS) in patients with a clinical course suggesting a diagnosis other than minimal change disease (MCD) and normal histology, or minor, nondiagnostic changes on light microscopy (LM), we used a protocol for systematic and extensive electron...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809048472

    authors: Ben-Bassat M,Braslavsky D,Lotan D,Eisenstein B,Davidovitz M,Stark H

    更新日期:1988-01-01 00:00:00

  • Malignant meningioma of the parapharyngeal space: a case report.

    abstract::A case of a malignant meningioma arising in the left parapharyngeal space in a 29-year-old woman is reported. Electron microscopic examination of the tumor was critical in establishing the diagnosis. Meningiomas of the parapharyngeal space are extremely rare. This constitutes the first malignant case documented in thi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129609023238

    authors: Dominguez-Malagon H,Ordóñez NG

    更新日期:1996-01-01 00:00:00

  • Angiomyolipoma of the kidney with lymph node involvement.

    abstract::A case of renal angiomyolipoma with regional lymph node involvement is added to 20 cases previously reported. This represents the 11th case reported in a non-tuberous sclerosis patient. The electron microscopic features of the tumor are discussed and correlated with the light microscopic findings. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129109016260

    authors: Ansari SJ,Stephenson RA,Mackay B

    更新日期:1991-07-01 00:00:00

  • Diagnostic significance of mitochondria in four types of renal epithelial neoplasms: an ultrastructural study of 60 tumors.

    abstract::Mitochondrial morphology was studied in 60 renal epithelial neoplasms, including clear cell, papillary, chromophobe cell, and oncocytomas, to see if there are significant differences among the various subtypes. Mitochondria from the nephron tubular system obtained from 36 patients with glomerular diseases served as co...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709021939

    authors: Erlandson RA,Shek TW,Reuter VE

    更新日期:1997-09-01 00:00:00

  • Confocal laser scanning microscopy of liesegang rings in odontogenic cysts: analysis of three-dimensional image reconstruction.

    abstract::Liesegang rings are concentric noncellular lamellar structures, occasionally found in inflammatory tissues. They have been confused with various parasites, algas, calcification, and psammoma bodies. The authors examined Liesegang rings from oral inflammatory cysts by both optical and confocal laser scanning microscopy...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120902751288

    authors: Scivetti M,Lucchese A,Crincoli V,Pilolli GP,Favia G

    更新日期:2009-03-01 00:00:00

  • Value of transmission electron microscopy for primary ciliary dyskinesia diagnosis in the era of molecular medicine: Genetic defects with normal and non-diagnostic ciliary ultrastructure.

    abstract::Primary ciliary dyskinesia (PCD) is a genetic disorder causing chronic oto-sino-pulmonary disease. No single diagnostic test will detect all PCD cases. Transmission electron microscopy (TEM) of respiratory cilia was previously considered the gold standard diagnostic test for PCD, but 30% of all PCD cases have either n...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.1080/01913123.2017.1362088

    authors: Shapiro AJ,Leigh MW

    更新日期:2017-11-01 00:00:00

  • Sclerosing stromal tumor of the ovary: an ultrastructural and immunohistochemical analysis with histogenetic considerations.

    abstract::Sclerosing stromal tumors are rare, benign ovarian neoplasms of unknown etiology and histogenesis. Three sclerosing stromal tumors were evaluated by immunohistochemistry and electron microscopy and were compared to two thecomas and nonneoplastic ovarian mesenchymal tissue. The sclerosing stromal tumors and thecomas we...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209061364

    authors: Shaw JA,Dabbs DJ,Geisinger KR

    更新日期:1992-05-01 00:00:00

  • Weber-Christian disease associated with the tip variant of focal segmental glomerulosclerosis: a case report.

    abstract::Weber-Christian disease (W-CD) is associated with relapsing nodular panniculitis and a variety of systemic findings. Renal parenchymal involvement has been rarely reported. The authors describe a case of nephrotic syndrome in an African-American man with a W-CD flare. The patient had chills and low-grade fever with pa...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2012.736459

    authors: Sterling KA,Karam S,Taylor N,Cathro HP

    更新日期:2012-12-01 00:00:00

  • Ribosome-lamella complex of the lymphocytes in a case of plasmacytic lymphadenopathy with polyclonal hypergammaglobulinemia.

    abstract::A case of lymphoid hyperplasia with prominent plasmacytic proliferation histologically and with polyclonal hypergammaglobulinemia and anemia clinically was reported. This condition in a 54-year-old Japanese male was probably a type of plasma cell dyscrasia similar to a plasma cell variant of Castleman's disease. About...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409018570

    authors: Mikata A,Suzuki S,Suzuki H,Higo O,Shimoyama M

    更新日期:1984-01-01 00:00:00

  • Ultrastructural and histochemical study of the motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis.

    abstract::Motor end plates of the intrinsic laryngeal muscles in amyotrophic lateral sclerosis (ALS) were examined light and electron microscopically. Light microscopically, typical neurogenic changes such as small angulated fibers and grouped atrophy were found in the intrinsic laryngeal muscles. Acetylcholinesterase (AchE) ac...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129809032266

    authors: Yoshihara T,Ishii T,Iwata M,Nomoto M

    更新日期:1998-03-01 00:00:00

  • Malignant mesothelioma with intracytoplasmic crystalline inclusions.

    abstract::A 60-year-old female presented with a history of hoarseness, cough, chest pain, and dyspnea and a needle biopsy sample was submitted for histology. Light microscopy showed sheets of tumor cells with eosinophilic cytoplasm containing multiple crystals and eccentrically located nuclei. Electron microscopy showed large i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120601172489

    authors: Goedhals J,Beukes CA,Cooper S

    更新日期:2007-01-01 00:00:00

  • Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes.

    abstract::The morphology, karyotype, in vitro growth properties, and expression of tyrosine kinase receptors and proto-oncogenes are reported for a newly established large cell undifferentiated lung carcinoma cell line (RVH-6849). The results were analyzed concomitantly with those for two well-established cell lines from an ade...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209057829

    authors: Wang NS,Liu C,Emond J,Tsao MS

    更新日期:1992-07-01 00:00:00

  • Monoclonal glomerulopathy with features of cryoglobulinemic glomerulopathy in murine multiple myeloma model.

    abstract::In vivo and animal models of monoclonal light chain-associated renal diseases are limited. The Vk*MYC transgenic model with multiple myeloma in 50-70 weeks old mice with renal involvement has been reported before, but detailed renal pathologic changes have not been well documented. This study fully investigated pathol...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2020.1841349

    authors: Zhang PL,Herrera GA,Liu B

    更新日期:2020-11-20 00:00:00

  • Immunogold detection of chromogranin A in the neuroendocrine tumor.

    abstract::Immunogold ultrastructural localization of chromogranin A in secretory granules within tumor cells provides convincing evidence of endocrine or neuroendocrine differentiation. A modified immunogold method (designed for use on osmicated tissue) produced positive labeling of small granules not only in well-differentiate...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129309015402

    authors: Silver MM,Lines LD,Hearn SS

    更新日期:1993-01-01 00:00:00

  • Alpha and beta subunits of glycoprotein hormones in argyrophil pituitary tumors with small granule cells.

    abstract::A group of 33 functionless pituitary tumors with small argyrophil groups (SAG) were collected from a series of 200 pituitary adenomas (16.5% of all adenomas). Histologically, the tumors showed an unusually high frequency of trabecular patterns, perivascular pseudo-rosettes, and oncocytoid transformation. Immunoreactiv...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140570

    authors: Capella C,Buffa R,Usellini L,Frigerio B,Jehenson P,Sessa F,Solcia E

    更新日期:1983-01-01 00:00:00

  • Reduplicated basal lamina in clear-cell carcinoma of the ovary: an immunohistochemical and electron microscopic study.

    abstract::Clear-cell carcinomas of the female genital tract are uncommon tumors that usually arise in the ovary, cervix, or vagina. The objectives of the present study were to examine the immunohistochemical and ultrastructural characteristics of 18 of these tumors and to determine whether any distinctive features were present ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129609016357

    authors: Kwon TJ,Ro JY,Tornos C,Ordonez NG

    更新日期:1996-11-01 00:00:00

  • A fast method for processing biologic material for electron microscopic diagnosis in infectious disease.

    abstract::A fast method for processing biologic material for electron microscopy for precise and specific diagnosis of infectious agents is an increasing necessity. After different, reportedly fast methods were tested, a useful and quick technique was developed that provides well-preserved cellular structures, enabling the etio...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129209057832

    authors: Duarte MI,Mariano ON,Takakura CF,Everson D,Corbett CE

    更新日期:1992-07-01 00:00:00

  • Differentiation of human monocytes in vitro following exposure to Canova in the absence of cytokines.

    abstract::Canova is an immunomodulatory, homeopathic preparation that has been shown to activate macrophages in vitro and in vivo, with resultant enhanced spreading of the cells and formation of microvillus extensions from the cell body. Since monocytes are the precursor cells of macrophages and dendritic cells, the objective o...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802062729

    authors: Smit E,Pretorius E,Anderson R,Oommen J,Potjo M

    更新日期:2008-07-01 00:00:00

  • Disseminated tubuloreticular inclusions in acquired immunodeficiency syndrome (AIDS).

    abstract::Tissue biopsies and peripheral blood samples from 10 patients with the characteristic clinical features of acquired immunodeficiency syndrome (AIDS) were examined by electron microscopy and ultracytochemical myeloperoxidase technique. Abundant tubuloreticular inclusions (TRI) were detected within the endoplasmic retic...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140585

    authors: Kostianovsky M,Kang YH,Grimley PM

    更新日期:1983-06-01 00:00:00

  • Myoepithelial cells in lobular carcinoma in situ of the breast: a parallel immunocytochemical and ultrastructural study.

    abstract::The distribution and morphology of myoepithelial cells in one case of normal breast and in 4 cases of lobular carcinoma in situ (LCIS) were studed by immunoperoxidase and immunofluorescence with anti-actin antisera and by electron microscopy. The actin-rich cells appeared to lay flattened on the basement membrane, or ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128109048305

    authors: Bussolati G,Botto Micca FB,Eusebi V,Betts CM

    更新日期:1981-07-01 00:00:00

  • Renal malakoplakia: report of a case with multifocal involvement.

    abstract::The authors report the light microscopic and ultrastructural features in one case of malakoplakia involving the kidney, the urinary bladder, and the skin. The kidney was excised. Lesions of the urinary bladder and the skin regressed after topical treatment with cholinergic agonists and antimicrobial drugs. This case i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709016374

    authors: Lloreta J,Cañas MA,Munné A,Arumí M,Bielsa O,Gelabert A,Serrano S

    更新日期:1997-11-01 00:00:00

  • Glial fibrillary acidic protein (GFAP) immunoreactivity in peripheral nerve sheath tumors.

    abstract::A spectrum of 24 benign and malignant nerve sheath tumors and 10 non-neural spindle-cell tumors were studied by light microscopy for the presence of glial fibrillary acidic protein (GFAP) immunoreactivity by the peroxidase-antiperoxidase (PAP) technique. In 8 cases, these results were compared to their electron micros...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141487

    authors: Memoli VA,Brown EF,Gould VE

    更新日期:1984-01-01 00:00:00

  • Primary ependymoma of the retropubic space in a male patient.

    abstract::We report a case of primary intraabdominal ependymoma arising in the retropubic space of a male patient. An incidental intraabdominal mass was discovered in a 51-year-old man. Radiological studies revealed a 10 cm, solid and cystic tumor located in the Retzius fossa. Microscopically, the lesion was characterized by mu...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913123.2020.1836104

    authors: Tasar Kapakli E,Kosemehmetoglu K,Kaymaz F,Akdogan B,Ozmen M,Baydar DE

    更新日期:2020-11-20 00:00:00

  • Uncompacted myelin lamellae in peripheral nerve biopsy.

    abstract::Since 1979, the authors have studied 49 peripheral nerve biopsies presenting uncompacted myelin lamellae (UML). Based on the ultrastructural pattern of UML they propose a 3-category classification. The first category includes cases displaying regular UML, which was observed in 43 cases; it was more frequent in 9 cases...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120309941

    authors: Vital C,Vital A,Bouillot S,Favereaux A,Lagueny A,Ferrer X,Brechenmacher C,Petry KG

    更新日期:2003-01-01 00:00:00

  • Testicular stromal tumor: ultrastructural, immunohistochemical, and gel electrophoretic evidence of epithelial differentiation.

    abstract::A testicular tumor, removed from a 52-year-old man, was composed of uniform spindle cells and abundant interposed collagen, and was histologically diagnosed as a stromal tumor. Electron microscopy revealed cords of cells sometimes surrounded by a basal lamina. Desmosome-like junctions were found between some cells, an...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609007209

    authors: Miettinen M,Salo J,Virtanen I

    更新日期:1986-01-01 00:00:00

  • Fine structure of ossification in craniopharyngiomas.

    abstract::Three cases of adamantinomatous craniopharyngiomas were examined by light and electron microscopy and special attention was paid to the formation of ossified tissue. The tumors were composed of neoplastic epithelial cells with keratinized cell nests and fibrous connective tissue. Keratinized cell masses sometimes dire...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131299281374

    authors: Sato K,Kubota T

    更新日期:1999-11-01 00:00:00