Uncompacted myelin lamellae in peripheral nerve biopsy.

Abstract:

:Since 1979, the authors have studied 49 peripheral nerve biopsies presenting uncompacted myelin lamellae (UML). Based on the ultrastructural pattern of UML they propose a 3-category classification. The first category includes cases displaying regular UML, which was observed in 43 cases; it was more frequent in 9 cases with polyneuropathy organomegaly endocrinopathy m-protein skin changes (POEMS) syndrome as well as in 1 case of Charcot-Marie-Tooth 1B with a novel point mutation in the P0 gene. The second category consists of cases showing irregular UML, observed in 4 cases with IgM monoclonal gammopathy and anti-myelin-associated glycoprotein (MAG) activity. This group included 1 benign case and 3 B-cell malignant lymphomas. The third category is complex UML, which was present in 2 unrelated patients with an Arg 98 His missense mutation in the P0 protein gene. Irregular and complex UML are respectively related to MAG and P0, which play a crucial role in myelin lamellae compaction and adhesion.

journal_name

Ultrastruct Pathol

authors

Vital C,Vital A,Bouillot S,Favereaux A,Lagueny A,Ferrer X,Brechenmacher C,Petry KG

doi

10.1080/01913120309941

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

1-5

issue

1

eissn

0191-3123

issn

1521-0758

pii

BR3NL7KKR4AV745T

journal_volume

27

pub_type

杂志文章
  • Light microscopic and ultrastructural evidence of in vivo phagocytosis of Helicobacter pylori by neutrophils.

    abstract::Helicobacter pylori is believed to cause chronic active gastritis. Infection/colonization of the gastric mucosal surface induces a mucosal inflammatory reaction in the form of lymphocytic aggregates, plasma cells and, particularly, neutrophils, which may, in turn, damage the mucosal epithelium. In vitro studies demons...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131200750035049

    authors: Zu Y,Cassai ND,Sidhu GS

    更新日期:2000-09-01 00:00:00

  • Bartonellosis as cause of death after red blood cell unit transfusion.

    abstract::The authors present the case of a young man with aplastic anemia who went into shock and died after several red blood cell unit transfusions. Immunohematological studies did not show any abnormality and blood cultures from patients and blood bags were negative. The ultrastructural findings, allied with current scienti...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120902785567

    authors: Magalhães RF,Urso Pitassi LH,Lania BG,Barjas-Castro ML,Neves Ferreira Velho PE

    更新日期:2009-07-01 00:00:00

  • Fibrolamellar hepatic tumor with neurosecretory features and systemic deposition of AA amyloid.

    abstract::A 28-year-old man presented with left cervical lymph node metastases and a 7-cm mass in the left lobe of the liver. Biopsy material from both sites revealed a fibrolamellar hepatocarcinoma (FLHC) with immunocytochemical and ultrastructural evidence of neurosecretory differentiation. The patient refused treatment. He d...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129409016302

    authors: Lloreta J,Vadell C,Fabregat X,Serrano S

    更新日期:1994-01-01 00:00:00

  • Epithelioid variant of pleomorphic liposarcoma: a comparative immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelial malignancies.

    abstract::Pleomorphic liposarcoma (PL) is the least common subtype of liposarcoma, displaying a lipoblastic, malignant fibrous histiocytoma (MFH)-like and, less frequently, an epithelioid growth pattern. The epithelioid morphology in PL is still underrecognized and may closely simulate other epithelial neoplasms, mainly adrenal...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120290104575

    authors: Huang HY,Antonescu CR

    更新日期:2002-09-01 00:00:00

  • Sellar glomangioma.

    abstract::A glomangioma (glomus tumor) arising in the pituitary region is described. The histologic and ultrastructural features were characteristic. The tumor was composed of epithelioid cells arranged in an organoid fashion around vascular channels and contained scattered mast cells. Electron microscopy revealed tumor cells t...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141853

    authors: Asa SL,Kovacs K,Horvath E,Ezrin C,Weiss MH

    更新日期:1984-01-01 00:00:00

  • Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.

    abstract::Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913121003788729

    authors: Eşrefoğlu M,Ara C

    更新日期:2010-10-01 00:00:00

  • Ultrastructure of poorly differentiated diffuse epithelial mesotheliomas.

    abstract::In differentiating diffuse epithelial mesothelioma from metastatic adenocarcinoma in pleural and peritoneal biopsies, the number and form of microvilli and the amount and distribution of tonofilaments are thought to be the most useful criteria. This report details 5 cases of diffuse epithelial mesothelioma in which th...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128409141472

    authors: Dardick I,Al-Jabi M,McCaughey WT,Srigley JR,van Nostrand AW,Ritchie AC

    更新日期:1984-01-01 00:00:00

  • Xanthogranulomatous appendicitis--an incidental finding of localized pathology.

    abstract::The clinical, histopathological, and electron microscopic features of an unusual case of xanthogranulomatous appendicitis are reported. The patient, a 37-year-old female, presented with typical signs of acute appendicitis and the appendix appeared slightly dilated at laparatomy. The histopathological sections showed n...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131200281291

    authors: Munichor M,Kerner H,Cohen H,Bickel A,Iancu TC

    更新日期:2000-01-01 00:00:00

  • Sarcomatoid renal cell carcinoma metastatic to the heart: report of a case.

    abstract::An unusual case of metastatic sarcomatoid renal cell carcinoma is presented. Fifteen months after nephrectomy for a typical clear cell carcinoma, a 63-year-old man presented with bilateral pleural effusions, cardiomegaly, and tamponade. A pericardial biopsy showed an anaplastic spindle cell tumor that was strongly ker...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129109016245

    authors: Bird DJ,Semple JP,Seiler MW

    更新日期:1991-07-01 00:00:00

  • Renal malakoplakia: report of a case with multifocal involvement.

    abstract::The authors report the light microscopic and ultrastructural features in one case of malakoplakia involving the kidney, the urinary bladder, and the skin. The kidney was excised. Lesions of the urinary bladder and the skin regressed after topical treatment with cholinergic agonists and antimicrobial drugs. This case i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913129709016374

    authors: Lloreta J,Cañas MA,Munné A,Arumí M,Bielsa O,Gelabert A,Serrano S

    更新日期:1997-11-01 00:00:00

  • Pulmonary blastomas of childhood: histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations.

    abstract::Pulmonary blastomas are rare neoplasms typically occurring in patients of pediatric age, clinically characterized by fever, respiratory distress, and radiologic findings of a pulmonary cystic and/or solid mass with partial or complete obliteration of emithorax. Their behavior is aggressive and outcome is poor due to f...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120500323456

    authors: Boldrini R,Devito R,Diomedi-Camassei F,Francalanci P,Inserra A,Boglino C,Donfrancesco A,Jenkner A,Callea F

    更新日期:2005-11-01 00:00:00

  • Hyaline inclusions in a synovial sarcoma following intra-arterial chemotherapy.

    abstract::Hyaline inclusions were noted in cells of a typical synovial sarcoma following intra-arterial chemotherapy. Ultrastructural study revealed that the inclusions were cytoplasmic aggregates of intermediate filaments. Since the inclusions were not present in the tumor prior to treatment, it is suggested that they may have...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128209018553

    authors: Sajjad SM,Mackay B

    更新日期:1982-10-01 00:00:00

  • Heterogeneity of malignant schwannomas.

    abstract::Six malignant schwannomas were studied by electron microscopy and immunohistochemistry for S-100 protein at the light and electron microscopic levels to clarify the nature of the tumor cells. Three tumors (group A) were composed of poorly differentiated tumor cells and showed no immunoreactivity for S-100 protein. One...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128809048479

    authors: Hirose T,Sano T,Hizawa K

    更新日期:1988-01-01 00:00:00

  • A new tool improves diagnostic test performance for transmission em evaluation of axonemal dynein arms.

    abstract::Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/01913123.2013.815081

    authors: Funkhouser WK 3rd,Niethammer M,Carson JL,Burns KA,Knowles MR,Leigh MW,Zariwala MA,Funkhouser WK Jr

    更新日期:2014-08-01 00:00:00

  • Comparison of the myotoxic effects of levobupivacaine, bupivacaine, and ropivacaine: an electron microscopic study.

    abstract::The aim of this study was to investigate the myotoxic effects of bupivacaine, ropivacaine, and levobupivacaine which were applied intramuscularly to rat skeletal muscle. Forty Wistar-Albino rats were divided into four groups. In the study, .5% bupivacaine (Group B), .5% ropivacaine (Group R), .5% levobupivacaine (Grou...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2015.1014610

    authors: Öz Gergin Ö,Yıldız K,Bayram A,Sencar L,Coşkun G,Yay A,Biçer C,Özdamar S,Polat S

    更新日期:2015-05-01 00:00:00

  • Ultrastructural aspect of myocarditis: its relevance for the diagnosis.

    abstract::The Dallas consensus was used to reveal active or borderline inflammatory loci by light microscopy (LM). When lymphocyte-cardiocyte interaction was observed by electron microscopy (EM), the deleterious or dormant pattern of inflammatory process was recognized. The first was determined by lymphocytes that adhered to ca...

    journal_title:Ultrastructural pathology

    pub_type: 临床试验,杂志文章

    doi:10.3109/01913129509014620

    authors: Milin J,Stojsić D,Vucković D,Benc D,Hadzić M,Stojsić A,Zivkov-Saponja D

    更新日期:1995-11-01 00:00:00

  • SEM Study of apical morphological alterations in primary teeth with vital and necrotic pulps.

    abstract::This study evaluated, by SEM, the morphology of human primary teeth roots. Twenty-four teeth were divided into 3 groups: pulp vitality (group I) and pulp necrosis without (group II) and with apical periodontitis (group III). Roots were analyzed by the presence of periodontal ligament (PDL) fibers and resorption areas....

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913120903275642

    authors: da Silva LA,Fernandes PM,da Silva RA,Nelson-Filho P,Rocha LB,Rossi MA

    更新日期:2009-10-01 00:00:00

  • Ameliorative effect of Pimpinella anisum oil on immunohistochemical and ultrastuctural changes of cerebellum of albino rats induced by aspartame.

    abstract::The study aims to investigate the protective effect of Pimpinella anisum oil on aspartame (ASP) which resulted in cerebellar changes. The rats were divided into four equal groups: Group 1: (control group): served as control animals. Group 2: control P. anisum oil received .5 mL/kg/d/b wt. once daily. Group 3 (ASP grou...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2014.889259

    authors: Abdul-Hamid M,Gallaly SR

    更新日期:2014-05-01 00:00:00

  • Ultrastructural study of a perineurioma.

    abstract::A case of soft tissue tumor in the left brachialis muscle of a 49-year-old Japanese female patient was studied by electron microscopy. The tumor was diagnosed as intramuscular myxoma by light microscopy, but electron microscopic observation revealed that the tumor almost entirely consisted of cells similar to normal p...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913128809032234

    authors: Ohno T,Park P,Akai M,Kamura S,Murase K,Kimura H,Kadoya H,Manabe S,Nagao K,Sugano I

    更新日期:1988-09-01 00:00:00

  • Spectrum of low-grade fibrosarcomas: a comparative ultrastructural analysis of low-grade myxofibrosarcoma and fibromyxoid sarcoma.

    abstract::Low-grade fibrosarcomas have recently gained increasing attention in the literature, especially with the fall in popularity polls of the ubiquitous malignant fibrous histiocytoma (MFH). Firstly, most tumors previously known as myxoid MFH are labeled presently as myxofibrosarcomas. Secondly, the recognition and better ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/019131290882259

    authors: Antonescu CR,Baren A

    更新日期:2004-09-01 00:00:00

  • Renal cell carcinoma metastatic to a pituitary FSH/LH adenoma: case report and review of the literature.

    abstract::Abstract Metastases to the pituitary occur more frequently in patients with widespread cancer and mainly involve the posterior lobe. A few cases of metastatic carcinoma to a pituitary adenoma have been described so far. Here, the authors present an additional case of a clear cell renal cell carcinoma (CCRCC) metastati...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章,评审

    doi:10.3109/01913123.2014.937843

    authors: Magnoli F,Finzi G,Riva C,Capella C

    更新日期:2014-12-01 00:00:00

  • Malignant mesothelioma with intracytoplasmic crystalline inclusions.

    abstract::A 60-year-old female presented with a history of hoarseness, cough, chest pain, and dyspnea and a needle biopsy sample was submitted for histology. Light microscopy showed sheets of tumor cells with eosinophilic cytoplasm containing multiple crystals and eccentrically located nuclei. Electron microscopy showed large i...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120601172489

    authors: Goedhals J,Beukes CA,Cooper S

    更新日期:2007-01-01 00:00:00

  • Histological and biochemical effects of dexmedetomidine on liver during an inflammatory bowel disease.

    abstract::Inflammation in the liver is an extraintestinal manifestation that is frequently seen during inflammatory bowel diseases (IBD). The authors investigated histopathologycal, ultrastructural and antioxidant effects of dexmedetomidine (Dex) on liver during trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel di...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913123.2013.829150

    authors: Gul M,Kayhan B,Elbe H,Dogan Z,Otlu A

    更新日期:2015-02-01 00:00:00

  • 5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas.

    abstract::Aberrant transcription of the FHIT gene has been observed in many solid tumors, suggesting that 5'-CpG island methylation of the FHIT gene is involved in tumor development. The authors investigated the status of the 5'-CpG island methylation of the FHIT gene and protein expression in a series of 40 cervical carcinomas...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120390250329

    authors: Wu Q,Shi H,Suo Z,Nesland JM

    更新日期:2003-11-01 00:00:00

  • Microvascular changes in human gastric carcinomas with coagulative necrosis: an ultrastructural study.

    abstract::Ultrastructural findings in three cases of gastric carcinoma with coagulative necrosis are reviewed with special emphasis on microvascular changes. Intratumoral microvasculature revealed more or less stabilized vessels. Some were characterized by a close association between pericytes and endothelial cells, whereas oth...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802289231

    authors: Caruso RA,Fedele F,Finocchiaro G,Pizzi G,Nunnari M,Gitto G,Fabiano V,Rigoli L

    更新日期:2008-09-01 00:00:00

  • Ultrastructural and immunohistochemical study of epithelioid hemangioendothelioma of bone: coexpression of epithelial and endothelial markers.

    abstract::Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVI...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:

    authors: van Haelst UJ,Pruszczynski M,ten Cate LN,Mravunac M

    更新日期:1990-03-01 00:00:00

  • Carcinoma versus cytokeratin-positive lymphoma: a case report emphasizing the diagnostic role of electron microscopy.

    abstract::Lymphoma diagnosis rarely needs electron microscopy (EM), but one area where it can be useful is in the distinction of cytokeratin-positive lymphoma from carcinoma. The authors describe such a case, where difficulties were encountered due to lack of antibody specificity, distinguishing reactive from tumoral cells, and...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120802625830

    authors: Eyden B,Chakrabarty B,Hatimy U

    更新日期:2009-01-01 00:00:00

  • Insular amyloid in a case of type III glycogenosis with a special reference to the origin of amyloid fibrils.

    abstract::Amyloid depositions of pancreatic islets were investigated with electron microscopy in a case of type III glycogenosis. Beta cells adjoining small amyloid depositions were shown to have cytoplasmic invaginations where closely packed amyloid fibrils were disclosed regularly orientated amyloid bundles. In the cytoplasm ...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128609032222

    authors: Takahashi M,Yokota T,Ishihara T,Uchino F,Kamei T

    更新日期:1986-01-01 00:00:00

  • Dose-dependent mercuric chloride tubular injury in rat kidney.

    abstract::Mercuric chloride (HgCl(2)) produces an acute renal failure in experimental animal models. Since the mechanism of tubular injury has not completely been clarified, this morpho-quantitative study was undertaken to better understand the effects of 2 sublethal doses (T1=1 mg/kg and T3.5=3.5 mg/kg) of HgCl(2) in rat proxi...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.1080/01913120309921

    authors: Stacchiotti A,Borsani E,Rodella L,Rezzani R,Bianchi R,Lavazza A

    更新日期:2003-07-01 00:00:00

  • Alpha and beta subunits of glycoprotein hormones in argyrophil pituitary tumors with small granule cells.

    abstract::A group of 33 functionless pituitary tumors with small argyrophil groups (SAG) were collected from a series of 200 pituitary adenomas (16.5% of all adenomas). Histologically, the tumors showed an unusually high frequency of trabecular patterns, perivascular pseudo-rosettes, and oncocytoid transformation. Immunoreactiv...

    journal_title:Ultrastructural pathology

    pub_type: 杂志文章

    doi:10.3109/01913128309140570

    authors: Capella C,Buffa R,Usellini L,Frigerio B,Jehenson P,Sessa F,Solcia E

    更新日期:1983-01-01 00:00:00