Granular cell tumor: a review of the pathology and histogenesis.

Abstract:

:As the name suggests, the histogenesis of the granular cell tumor is uncertain, but this intriguing neoplasm has occasioned much speculation and controversy since its description in 1926 as a myoblastoma. Though ubiquitous in its anatomic location, it is usually small, solitary, benign, and readily recognized by routine light microscopy, and questions concerning it are principally academic. However, a small number of cases are malignant and they can be difficult to identify in paraffin sections. The combined input from immunohistochemistry and electron microscopy has greatly clarified understanding of the morphology of this lesion and both methods are helpful when the differential diagnosis is a problem. The cell of origin is still undecided, and although distinct neural features argue for Schwannian origin, the noncommittal term granular cell tumor continues to be appropriate.

journal_name

Ultrastruct Pathol

authors

Ordóñez NG,Mackay B

doi

10.1080/019131299281545

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

207-22

issue

4

eissn

0191-3123

issn

1521-0758

journal_volume

23

pub_type

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