Abstract:
:Microvascular injury is an important factor in renal allograft survival. Repeated episodes of endothelial injury from chronic antibody-mediated rejection typically manifest at the ultrastructural level as circumferential multilayering of remodeled glomerular basement membrane material and peritubular capillary basal lamina. In contrast to this typical pattern of microvascular injury, a renal transplantation case is presented in which focally dilated and multilayered segments of peritubular capillary basal lamina bearing lipid droplets were interspersed with ultrastructurally normal unilayered segments of basal lamina devoid of lipid droplets. Glomerular basement membranes were not affected by this process. The peak incidence of lipid droplets within the peritubular capillary walls coincided with a peak in apoptotic activity within the allograft. Lesser amounts of the same lipidic material were identified in the mesangial matrix and an arteriolar wall. Mesangial electron-dense deposits were detected at two weeks posttransplantation and their appearance coincided with elevated immunological activity in the glomeruli, as determined by immunofluorescence microscopy. The unusual ultrastructure and immunological activity observed in this case may reflect a process of impaired apoptotic clearance within the allograft. The six biopsies from a single patient are discussed in the setting of a highly sensitized renal transplant recipient who received prophylactic terminal complement blockade by eculizumab. The findings may be relevant to the study of apoptosis, efferocytosis, microvascular injury, eculizumab, rejection, lupus, and drug-related disease.
journal_name
Ultrastruct Patholjournal_title
Ultrastructural pathologyauthors
Brealey JK,Cassidy J,Manavis Jdoi
10.1080/01913123.2018.1484542subject
Has Abstractpub_date
2018-07-01 00:00:00pages
323-332issue
4eissn
0191-3123issn
1521-0758journal_volume
42pub_type
杂志文章abstract::The c-erbB-2 gene product was demonstrated immunoelectron microscopically in human transitional cell carcinomas of the urinary tract. Two antibodies specific for the c-erbB-2 gene product were used: a polyclonal antibody directed to the intracellular domain and a monoclonal antibody recognizing an epitope in the extra...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129009007219
更新日期:1990-09-01 00:00:00
abstract::The authors report a renal cell carcinoma composed largely of spindle cells of Fuhrman's nuclear grade II in which the bland appearance of the cells and low mitotic index were reminiscent of a benign or low-grade smooth muscle tumor. Keratin immunostaining was positive, but evidence of epithelial differentiation was o...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129809032262
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:Low-frequency noise (LFN) is a ubiquitous physical stressor known to cause degenerative cellular changes and organ alterations with functional repercussions both in humans and animals. MATERIALS AND METHODS:After acceptance of the study protocol by a local ethics committee, 20 Wistar rats were randomly di...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2013.861569
更新日期:2014-05-01 00:00:00
abstract::A 28-year-old man presented with left cervical lymph node metastases and a 7-cm mass in the left lobe of the liver. Biopsy material from both sites revealed a fibrolamellar hepatocarcinoma (FLHC) with immunocytochemical and ultrastructural evidence of neurosecretory differentiation. The patient refused treatment. He d...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409016302
更新日期:1994-01-01 00:00:00
abstract::Electron microscopy of the central nervous system surface structure is described in two fetuses with Fukuyama congenital muscular dystrophy (FCMD). In addition to relatively large surface defects, many minute defects less than several micrometers in size associated with protrusion of glial cytoplasm were observed in t...
journal_title:Ultrastructural pathology
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doi:10.3109/01913129709021933
更新日期:1997-07-01 00:00:00
abstract::Microsporidia are ubiquitous obligate eukaryotic intracellular parasites that are now felt to be more akin to degenerate fungi than to protozoa. Microsporidia can be highly pathogenic, causing a broad range of symptoms in humans, especially individuals who are immunocompromised. The vast majority of human cases of mic...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120590951257
更新日期:2005-05-01 00:00:00
abstract::By means of optical and electron microscopy and by atomic absorption spectrophotometry in a graphite chamber, this study evaluated the effect of temperature (22-35 degrees C) on lesions in the kidney, liver, and brain, and on concentrations of lead caused by the administration of 2 and 5 mg/kg/IP of lead acetate to Sw...
journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129609016324
更新日期:1996-05-01 00:00:00
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journal_title:Ultrastructural pathology
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doi:10.3109/01913128109031504
更新日期:1981-01-01 00:00:00
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902785567
更新日期:2009-07-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120601172489
更新日期:2007-01-01 00:00:00
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/019131200750035049
更新日期:2000-09-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129709016374
更新日期:1997-11-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.960544
更新日期:2015-04-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2014.946635
更新日期:2014-12-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902787076
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journal_title:Ultrastructural pathology
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409023225
更新日期:1994-09-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128209016642
更新日期:1982-04-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2010.548113
更新日期:2011-05-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913129409023213
更新日期:1994-07-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.1080/01913120902751288
更新日期:2009-03-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913123.2015.1014612
更新日期:2015-01-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章
doi:10.3109/01913128609007209
更新日期:1986-01-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 杂志文章,随机对照试验
doi:10.3109/01913123.2013.815081
更新日期:2014-08-01 00:00:00
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journal_title:Ultrastructural pathology
pub_type: 历史文章,杂志文章,评审
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更新日期:2001-05-01 00:00:00