Differences in nuclear pore density among human choroidal melanoma cell types.

Abstract:

:Two cases of mixed cell type choroidal melanoma were examined by means of conventional and freeze-fracture electron microscopy. Data on average nuclear pore density were readily collected from freeze-fracture replicas of spindle A, spindle B, and epithelioid cells. Highly significant (p less than 0.001) differences in pore densities were found among the three cell types. Pore density was lowest in spindle A cells, intermediate in spindle B cells, and highest in epithelioid cells. The possible relationship between nuclear pore density and nucleolar activity as well as the potential usefulness of this new finding as a prognostic indicator in cases of choroidal melanoma are discussed.

journal_name

Ultrastruct Pathol

authors

Sacks-Wilner R,Freddo TF

doi

10.3109/01913129009032246

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

311-9

issue

4

eissn

0191-3123

issn

1521-0758

journal_volume

14

pub_type

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