Abstract:
:The cytotoxic necrotizing factor type 1 (CNF1) fromE. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Falzano L,Fiorentini C,Boquet P,Donelli Gdoi
10.1007/BF00746055subject
Has Abstractpub_date
1993-01-01 00:00:00pages
S56-8issue
Suppl 1eissn
0920-9069issn
1573-0778journal_volume
11pub_type
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