Abstract:
:MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer.
journal_name
Cytotechnologyjournal_title
Cytotechnologyauthors
Tan PY,Wen LJ,Li HN,Chai SWdoi
10.1007/s10616-020-00418-3subject
Has Abstractpub_date
2020-10-01 00:00:00pages
751-761issue
5eissn
0920-9069issn
1573-0778pii
10.1007/s10616-020-00418-3journal_volume
72pub_type
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