Enhanced contractility of vascular smooth muscle after brief exposure to arsenate.

abstract：:Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

journal_title：Environmental toxicology and pharmacology

authors： Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

更新日期：2014-09-01 00:00:00

abstract：:In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with...

journal_title：Environmental toxicology and pharmacology

authors： Boobis AR

更新日期：1996-10-15 00:00:00

abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

journal_title：Environmental toxicology and pharmacology

authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

更新日期：2009-03-01 00:00:00

abstract：:Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

journal_title：Environmental toxicology and pharmacology

authors： Wörner W,Schrenk D

更新日期：1998-12-01 00:00:00

abstract：:Chronic inflammation occurs systematically in the central nervous system during ageing, it has been shown that neuroinflammation plays an important role in the pathogenesis of many neurodegenerative disorders. Aspirin, a nonselective COX inhibitor, as well as ascorbic acid, has been purported to protect cerebral tissu...

journal_title：Environmental toxicology and pharmacology

authors： Kara Y,Doguc DK,Kulac E,Gultekin F

更新日期：2014-05-01 00:00:00

abstract：:One purpose in this research was to determine the toxic effects of Cd on antioxidant enzymes of Oxya chinensis (Orthoptera: Acridoidae). Changes in the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (GPx) were measured in O. chinensis insects injected with Cd(...

journal_title：Environmental toxicology and pharmacology

authors： Lijun L,Xuemei L,Yaping G,Enbo M

更新日期：2005-11-01 00:00:00

abstract：:The wide range of potential health beneficial effects of isoflavones, including a chemoprentive action, have prompted us to study the potential benefits of genistein and daidzein in an experimental model of environmental pollution impact on lung tissue. A diesel engine placed was used to generate reproducible emission...

journal_title：Environmental toxicology and pharmacology

authors： Morin JP,Rumigny JF,Bion A,Dionnet F

更新日期：2002-11-01 00:00:00

abstract：:Exposure to lead (Pb) or polychlorinated biphenyls (PCBs) during early development has been associated with deficits in cognitive function in children (Pediatrics 87 (1991) 219; N. Engl. J. Med. 335 (1996) 783). These effects persist in the child long after exposure has ceased and body burdens have diminished. Despite...

journal_title：Environmental toxicology and pharmacology

authors： Gilbert ME,Lasley SM

更新日期：2002-09-01 00:00:00

abstract：:Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

journal_title：Environmental toxicology and pharmacology

authors： Chu H,Tang Q,Huang H,Hao W,Wei X

更新日期：2016-01-01 00:00:00

abstract：:Chromium (Cr) (VI) compounds are known carcinogens and mutagens. The mechanism of carcinogenicity and mutagenicity caused by chromium(VI) compounds remained unclear for several years. However, in the recent past chromium-induced carcinogenicity and/or mutagenicity was known to happen due to the generation of reactive ...

journal_title：Environmental toxicology and pharmacology

authors： Acharya UR,Mishra M,Mishra I,Tripathy RR

更新日期：2004-01-01 00:00:00

abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

journal_title：Environmental toxicology and pharmacology

authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

更新日期：2017-04-01 00:00:00

abstract：:We generated germ line-transgenic Xenopus laevis that monitors environmental heavy metal ions. Sperm nuclei were transduced with cDNA of enhanced green fluorescent protein (EGFP) driven by murine metallothionein-1 gene promoters and were microinjected into unfertilized eggs. The eggs developed to sexually matured adul...

journal_title：Environmental toxicology and pharmacology

authors： Oofusa K,Tooi O,Kashiwagi A,Kashiwagi K,Kondo Y,Obara M,Yoshizato K

更新日期：2003-04-01 00:00:00

abstract：:The use of surfactants in the development of a suitable formulation for insecticides should improve the solubility behavior, the permeability and the efficiency against pests meanwhile decrease the toxic risks of insecticides on human health. Cytotoxicity of insecticides including abamectin, chlorfluazuron, hexaflumur...

journal_title：Environmental toxicology and pharmacology

authors： Li D,Wu X,Yu X,Huang Q,Tao L

更新日期：2015-03-01 00:00:00

abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

journal_title：Environmental toxicology and pharmacology

authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

更新日期：1999-12-01 00:00:00

abstract：:The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutat...

journal_title：Environmental toxicology and pharmacology

authors： Kavitha P,Rao JV

更新日期：2008-09-01 00:00:00

abstract：:It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...

journal_title：Environmental toxicology and pharmacology

authors： Ashraf SS,Galadari S,Patel M

更新日期：2006-07-01 00:00:00

abstract：:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

journal_title：Environmental toxicology and pharmacology

authors： Anbarasi K,Sabitha KE,Devi CS

更新日期：2005-09-01 00:00:00

abstract：:The acute toxicity of cypermethrin to the amphipod Hyalella curvispina was evaluated by means of a toxicity test under laboratory conditions. Cypermethrin is one of the most widely used insecticides in Argentina. H. curvispina is a widely distributed and commonly abundant component of the invertebrate assemblages in s...

journal_title：Environmental toxicology and pharmacology

authors： Mugni H,Paracampo A,Marrochi N,Bonetto C

更新日期：2013-01-01 00:00:00

abstract：:Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an I...

journal_title：Environmental toxicology and pharmacology

authors： Bertero A,Augustyniak J,Buzanska L,Caloni F

更新日期：2019-08-01 00:00:00

abstract：:Paraquat (PQ) is a relatively safe and effective herbicide used all over the world. PQ is very toxic to all living organisms; and many cases of acute poisoning and death have been reported over the past decade. The main suggested potential mechanism for PQ toxicity is the production of superoxide radicals from the met...

journal_title：Environmental toxicology and pharmacology

authors： Mohammadi-Bardbori A,Ghazi-Khansari M

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...

journal_title：Environmental toxicology and pharmacology

authors： Dixit S,Mehra RD,Dhar P

更新日期：2020-04-01 00:00:00

abstract：:The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...

journal_title：Environmental toxicology and pharmacology

authors： Gateva S,Jovtchev G,Stergios M

更新日期：2013-07-01 00:00:00

abstract：:Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

journal_title：Environmental toxicology and pharmacology

authors： Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

更新日期：2020-04-01 00:00:00

abstract：:This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...

journal_title：Environmental toxicology and pharmacology

authors： Feng H,Gao Y,Zhao L,Wei Y,Li Y,Wei W,Wu Y,Sun D

更新日期：2013-05-01 00:00:00

abstract：:Marine microbes have been a storehouse of bioactive metabolites with tremendous potential as drug candidates. Marine microorganism derived secondary metabolites (chemical compounds/peptides) are considered to be a burning area of research since recent past. Many of such compounds have been proven to be anti-bacterial,...

journal_title：Environmental toxicology and pharmacology

authors： Bhatnagar I,Kim SK

更新日期：2012-11-01 00:00:00

abstract：:The Tokyo subway sarin attack was the second documented incident of nerve gas poisoning in Japan. The St. Luke's International Hospital received 640 patients on the day of the attack. Reduction in plasma cholinesterase (ChE) activity was generally associated with the severity of acute signs of toxicity. With time and ...

journal_title：Environmental toxicology and pharmacology

authors： Okumura T,Hisaoka T,Naito T,Isonuma H,Okumura S,Miura K,Maekawa H,Ishimatsu S,Takasu N,Suzuki K

更新日期：2005-05-01 00:00:00

abstract：:In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...

journal_title：Environmental toxicology and pharmacology

authors： Kamal A,Malik RN,Fatima N,Rashid A

更新日期：2012-07-01 00:00:00

abstract：:In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed...

journal_title：Environmental toxicology and pharmacology

authors： Roy SS,Ghosh S

更新日期：2020-04-01 00:00:00

abstract：UNLABELLED:The studies aimed at evaluation of cigarette smoke effect on heart rate turbulence (HRT) in patients with arterial hypertension (AH). 223 consecutive individuals were qualified to the studies. The following groups of patients not suffering from other disease which may affect HRT were distinguished: 1--patien...

journal_title：Environmental toxicology and pharmacology

authors： Gać P,Sobieszczańska M

更新日期：2014-03-01 00:00:00

abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

journal_title：Environmental toxicology and pharmacology

authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

更新日期：2013-11-01 00:00:00