Abstract：
:Marine microbes have been a storehouse of bioactive metabolites with tremendous potential as drug candidates. Marine microorganism derived secondary metabolites (chemical compounds/peptides) are considered to be a burning area of research since recent past. Many of such compounds have been proven to be anti-bacterial, anti-fungal, anti-algal, anti-HIV, anti-helminthic, anti-protozoan, anti-tumor and anti-allergic agents. Marine bacteria and fungi have been reported to be the producers of such compounds owing to their defense mechanisms and metabolic by products. Although the number of natural products isolated from these classes of marine microbial flora is large, a limited number of such compounds reach the clinical trial and even less number of them get approved as a drug. Here we discuss the recent studies on the isolation, characterization and the pharmacological significances of anti-bacterial, anti-fungal and anti-infective agents of marine microbial origin. Further, the clinical status of such compounds has also been discussed in comparison with those derived from their terrestrial counterparts.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Bhatnagar I,Kim SKdoi
10.1016/j.etap.2012.08.016subject
Has Abstractpub_date
2012-11-01 00:00:00pages
631-43issue
3eissn
1382-6689issn
1872-7077pii
S1382-6689(12)00133-0journal_volume
34pub_type
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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