Abstract：
:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investigated by assessing morphology (mitophagosome and mitolysosome) and relevant proteins (PINK1, LC3 II/I, and COX IV). Additionally, the relationship of mitophagy and proliferation was explored through the use of mitophagy inhibitors (CsA, Mdivi-1). Interestingly, the inhibition of mitophagy rescued proliferation arrest by restoring COX-2 protein level and countered the elimination of mitochondria-located COX-2 and up-regulated the COX-2 mRNA level. Taken together, our findings indicated that mitophagy can be induced and can inhibit proliferation by reducing COX-2 in HepG2 cells during As2O3 treatment.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Niu Z,Zhang W,Gu X,Zhang X,Qi Y,Zhang Ydoi
10.1016/j.etap.2016.06.006subject
Has Abstractpub_date
2016-07-01 00:00:00pages
212-21eissn
1382-6689issn
1872-7077pii
S1382-6689(16)30144-2journal_volume
45pub_type
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
