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The effect of calorie restriction on acute ethanol-induced oxidative and nitrosative liver injury in rats.

Abstract：

:The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR40-50); (3) ethanol-treated group (E); (4) calorie-restricted, ethanol-treated groups (E+CR60-70 and E+CR40-50). Ethanol was administered in 5 doses of 2g/kg every 12h, and duration of CR was 5 weeks before ethanol treatment. Malondialdehyde and nitrite and nitrate level were significantly lower in E+CR60-70 and higher in E+CR40-50 vs. E group. Liver reduced glutathione content and activity of both superoxide dismutase izoenzymes were significantly higher in E+CR60-70 and lower in E+CR40-50 vs. E group. Oxidative stress may be a potential mechanism of hormetic effects of CR on acute ethanol-induced liver injury.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Mladenović D,Ninković M,Aleksić V,Šljivančanin T,Vučević D,Todorović V,Stanković M,Stanojlović O,Radosavljević T

doi

10.1016/j.etap.2013.04.002

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

296-302

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(13)00085-9

journal_volume

36

pub_type

杂志文章

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