Betaine treatment decreased oxidative stress, inflammation, and stellate cell activation in rats with alcoholic liver fibrosis.

abstract：:Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-beta-d-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid co...

journal_title：Environmental toxicology and pharmacology

authors： Zhang YN,Song M,Ng TB,Zhao L,Liu F

更新日期：2013-09-01 00:00:00

abstract：:Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

journal_title：Environmental toxicology and pharmacology

authors： Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

更新日期：2015-11-01 00:00:00

abstract：:Excessive nitric oxide (NO) production in mice serum and testis due to aluminum (Al) exposure has been shown in previous studies. The aim of this study was to further investigate the role of NO on aluminum-suppressed testosterone level in male CD-1 mice. Each animal in six groups, was given intraperitoneal injections ...

journal_title：Environmental toxicology and pharmacology

authors： Guo CH,Lin CY,Yeh MS,Hsu GS

更新日期：2005-01-01 00:00:00

abstract：:Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...

journal_title：Environmental toxicology and pharmacology

authors： Wang X,Xu W,Fan M,Meng T,Chen X,Jiang Y,Zhu D,Hu W,Gong J,Feng S,Wu J,Li Y

更新日期：2016-04-01 00:00:00

abstract：:As a first-line anti-tuberculosis drug, isoniazid has a serious adverse side effect: hepatotoxicity. Therefore, the assessment and monitoring of hepatotoxicity from isoniazid to prevent liver injury are great concerns. In this experiment, we compared the levels of ALT in plasma and DNA methylation. 30 male SD rats wer...

journal_title：Environmental toxicology and pharmacology

authors： Zhang B,Sun S,Shen L,Zu X,Chen Y,Hao J,Huang X,Feng F

更新日期：2011-11-01 00:00:00

abstract：:The effects of prenatal exposure to 75 and 150 ppm of carbon monoxide (CO) were evaluated in vitro on the electrical parameters of extensor digitorum longus muscle of newborn rats, by means of computerized two intracellular microelectrode technique. Within the first 2 months of postnatal life the muscles from offsprin...

journal_title：Environmental toxicology and pharmacology

authors： De Luca A,Pierno S,Tricarico D,Carratù MR,Cagiano R,Cuomo V,Camerino DC

更新日期：1996-10-15 00:00:00

abstract：:Bisphenol A (BPA) is shown to be the endocrine disruptor that induces reproductive dysfunction in male animals. In this study, we aim to probe the effects of BPA exposure on induction of autophagy in goat Sertoli Cells (gSCs), as well as the relationship between autophagy and apoptosis. Results indicated that exposure...

journal_title：Environmental toxicology and pharmacology

authors： Zhang Y,Han L,Yang H,Pang J,Li P,Zhang G,Li F,Wang F

更新日期：2017-10-01 00:00:00

abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...

journal_title：Environmental toxicology and pharmacology

authors： Liu J,Carr S,Rinaldi K,Chandler W

更新日期：2005-09-01 00:00:00

abstract：:The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soy...

journal_title：Environmental toxicology and pharmacology

authors： Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K

更新日期：2015-03-01 00:00:00

abstract：:CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

journal_title：Environmental toxicology and pharmacology

authors： Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

更新日期：2015-11-01 00:00:00

abstract：:4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We a...

journal_title：Environmental toxicology and pharmacology

authors： Huang S,Cao S,Zhou T,Kong L,Liang G

更新日期：2018-09-01 00:00:00

abstract：:There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

journal_title：Environmental toxicology and pharmacology

authors： Cheong BH,Muradoglu M,Liew OW,Ng TW

更新日期：2015-07-01 00:00:00

abstract：:This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...

journal_title：Environmental toxicology and pharmacology

authors： Guo W,Shi X,Wang W,Zhang W,Li J

更新日期：2014-11-01 00:00:00

abstract：:In this study, we report the antioxidant and antitoxic potential of chemically synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone (DHF) with two molecules of Fmoc-t...

journal_title：Environmental toxicology and pharmacology

authors： Mohankumar T,Lalithamba HS,Manigandan K,Muthaiyan A,Elangovan N

更新日期：2020-10-01 00:00:00

abstract：:Diclofenac has recently been identified as a cause of the widespread vulture decline on the Indian subcontinent. Although the clinical signs and pathology have been described, the pathophysiology of toxicity remains unexplained. In the following study we attempt to validate the domestic fowl as a model, to allow for t...

journal_title：Environmental toxicology and pharmacology

authors： Naidoo V,Duncan N,Bekker L,Swan G

更新日期：2007-11-01 00:00:00

abstract：:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased...

journal_title：Environmental toxicology and pharmacology

authors： Dhuley JN,Naik SR

更新日期：1998-06-02 00:00:00

abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

journal_title：Environmental toxicology and pharmacology

authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

更新日期：1999-12-01 00:00:00

abstract：:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

journal_title：Environmental toxicology and pharmacology

authors： Anbarasi K,Sabitha KE,Devi CS

更新日期：2005-09-01 00:00:00

abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

journal_title：Environmental toxicology and pharmacology

authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

更新日期：2009-03-01 00:00:00

abstract：:Hexavalent chromium-mediated oxidative stress causes severe organ damage. The present study was designed to investigate the possible thyroprotective effect and underlying mechanisms of gallic acid using rat model of potassium dichromate-induced thyroid dysfunction. Forty adult male albino rats were divided into 4 grou...

journal_title：Environmental toxicology and pharmacology

authors： Mohamed HM,Abd El-Twab SM

更新日期：2016-12-01 00:00:00

abstract：:The neurotoxicity of monocrotophos (MCP) in the development of the serotonergic nervous system and swimming activity of larvae of the sea urchin, Hemicentrotus pulcherrimus, was examined. Lethal dose 50% of MCP was 43μg/ml. Overall morphology was not affected in larvae that received up to 30μg/ml of MCP soon after fer...

journal_title：Environmental toxicology and pharmacology

authors： Yao D,Ru S,Katow H

更新日期：2010-09-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is extracted from cruciferous vegetables and is well known for its anti-cancer, antioxidant and anti-inflammatory effects. This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae w...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Yang G,Liao Q,Zou Y,Du Y,Huang J

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

journal_title：Environmental toxicology and pharmacology

authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

更新日期：2012-07-01 00:00:00

abstract：:Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

journal_title：Environmental toxicology and pharmacology

authors： Vesela S,Kuca K,Jun D

更新日期：2008-05-01 00:00:00

abstract：:Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor inc...

journal_title：Environmental toxicology and pharmacology

authors： Zhang W,Liu K,Chen L,Chen L,Lin K,Fu R

更新日期：2014-07-01 00:00:00

abstract：:Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...

journal_title：Environmental toxicology and pharmacology

authors： Arslan M,Ila HB

更新日期：2015-03-01 00:00:00

abstract：:We previously reported that Astragalus polysaccharide (APS) extracted from Chinese medicine Astragalus membranaceus (Fisch.) Bge, attenuates hypertrophy of neonatal rat ventricular myocytes (NRVMs) induced by isoproterenol (Iso). The present study was designed to investigate the effects and the possible mechanism of A...

journal_title：Environmental toxicology and pharmacology

authors： Luan A,Tang F,Yang Y,Lu M,Wang H,Zhang Y

更新日期：2015-05-01 00:00:00

abstract：:Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

journal_title：Environmental toxicology and pharmacology

authors： Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

更新日期：2013-03-01 00:00:00

abstract：:Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

journal_title：Environmental toxicology and pharmacology

authors： Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

更新日期：1996-07-15 00:00:00

abstract：:The aliphatic ether 1,6-dimethoxyhexane (DMH) was previously identified as a testicular toxicant. Testis protein extracts from control and DMH-treated rats were subjected to two-dimensional gel electrophoresis for comparison of protein expression profiles. MALDI-ToF peptide mass fingerprinting of differentially expres...

journal_title：Environmental toxicology and pharmacology

authors： Pelletier G,Masson S,Wang YL,Wade MG,Mohottalage S,Kumarathasan P,Vincent R,Poon R,Chu I

更新日期：2007-09-01 00:00:00