Deferasirox-induced cytogenetic responses.

abstract：:Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-beta-d-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid co...

journal_title：Environmental toxicology and pharmacology

authors： Zhang YN,Song M,Ng TB,Zhao L,Liu F

更新日期：2013-09-01 00:00:00

abstract：:In order to better inform scientific decision making in the occupational environment, we need a better understanding of the toxicology of mixed exposures. In particular, we need an understanding of the dose-response relationship from the level of individual or population exposure down to the molecular level (and then ...

journal_title：Environmental toxicology and pharmacology

authors： Robinson P,Macdonell M

更新日期：2004-12-01 00:00:00

abstract：:Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...

journal_title：Environmental toxicology and pharmacology

authors： Sahoo PK,Pradhan LK,Aparna S,Agarwal K,Banerjee A,Das SK

更新日期：2020-11-01 00:00:00

abstract：:3-N-Oxalyl-l-2,3-diaminopropanoic acid (β-ODAP) induces neurolathyrism, a motor neuron disease. To elucidate the pathogenic mechanism of this process, the action of β-ODAP on the excitatory amino acid (EAA) receptor-mediated currents was examined using cloned EAA receptors expressed in Xenopus oocytes. On the voltage-...

journal_title：Environmental toxicology and pharmacology

authors： Kusama-Eguchi K,Ikegami F,Kusama T,Lambein F,Watanabe K

更新日期：1996-12-20 00:00:00

abstract：:This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. A...

journal_title：Environmental toxicology and pharmacology

authors： Xiu M,Pan L,Jin Q

更新日期：2016-06-01 00:00:00

abstract：:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...

journal_title：Environmental toxicology and pharmacology

authors： Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

更新日期：2012-05-01 00:00:00

abstract：:There are numerous examples, of both the identical and different effects of animals exposure to toxic agents, which can be compared in both, exposed prenatal/neonatal animals and exposed adults. In some instances, although the chemical and its metabolites are stored for long periods in adipose tissue, adult exposure (...

journal_title：Environmental toxicology and pharmacology

authors： Barnett JB

更新日期：1997-12-01 00:00:00

abstract：:Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities...

journal_title：Environmental toxicology and pharmacology

authors： Gowder SJ,Devaraj H

更新日期：2008-07-01 00:00:00

abstract：:Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...

journal_title：Environmental toxicology and pharmacology

authors： Robson L,Barnhoorn IEJ,Wagenaar GM

更新日期：2017-12-01 00:00:00

abstract：:Cannabis and Mandrax abuse is unique to South Africa; and most research has focused on the socio-economic impact rather than the adverse effects on the developing brain. Therefore, the aim of this study is to determine the effects of Mandrax and Cannabis alone and in combination on the developing brain by using primar...

journal_title：Environmental toxicology and pharmacology

authors： da Silva AA,Bester MJ,Pretorius E

更新日期：2007-01-01 00:00:00

abstract：:Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

journal_title：Environmental toxicology and pharmacology

authors： Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

更新日期：2014-01-01 00:00:00

abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

journal_title：Environmental toxicology and pharmacology

authors： Ghaly IS,Said A,Abdel-Wahhab MA

更新日期：2008-01-01 00:00:00

abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

journal_title：Environmental toxicology and pharmacology

authors： Müller S,Schmid P,Schlatter C

更新日期：1998-08-04 00:00:00

abstract：:Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

journal_title：Environmental toxicology and pharmacology

authors： Vesela S,Kuca K,Jun D

更新日期：2008-05-01 00:00:00

abstract：:Deltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnor...

journal_title：Environmental toxicology and pharmacology

authors： Kan Y,Cengiz EI,Ugurlu P,Yanar M

更新日期：2012-09-01 00:00:00

abstract：:The effects of oral administration of tamoxifen, 17α-ethynylestradiol (EE2), flutamide, and methyltestosterone (MT), on plasma vitellogenin levels of male and female medaka were investigated. Medaka were fed diets containing different concentrations of these chemicals for 7 days, and these plasma vitellogenin levels w...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Ikeda R,Hasan Q,Morita Y,Tamiya E

更新日期：2004-05-01 00:00:00

abstract：:Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...

journal_title：Environmental toxicology and pharmacology

authors： Chhay P,Murphy-Marion M,Samson Y,Girard D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...

journal_title：Environmental toxicology and pharmacology

authors： Khazdair MR,Rajabi O,Balali-Mood M,Beheshti F,Boskabady MH

更新日期：2018-03-01 00:00:00

abstract：:Aromatase catalyzes intraneuronal conversion of androgens to estrogens in the hypothalamus-preoptic area at a specific time during development. This local estrogen formation has a central role in sexual differentiation. To investigate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sexual differentiation,...

journal_title：Environmental toxicology and pharmacology

authors： Ikeda M,Inukai N,Mitsui T,Sone H,Yonemoto J,Tohyama C,Tomita T

更新日期：2002-01-01 00:00:00

abstract：:Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this st...

journal_title：Environmental toxicology and pharmacology

authors： Demir Y,Özaslan MS,Duran HE,Küfrevioğlu Öİ,Beydemir Ş

更新日期：2019-08-01 00:00:00

abstract：:The occurrence of chemical contaminants with DNA-damaging capacity in the environment represents a threat to human health as well as to the health of the ecosystem. This mini-review describes studies that were aimed to monitor at field conditions, the presence of such environmental toxicants and their DNA-damaging eff...

journal_title：Environmental toxicology and pharmacology

authors： Kleinjans JC,van Schooten FJ

更新日期：2002-07-01 00:00:00

abstract：:Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

journal_title：Environmental toxicology and pharmacology

authors： De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

更新日期：1996-02-15 00:00:00

abstract：:The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVI...

journal_title：Environmental toxicology and pharmacology

authors： Engin AB,Engin ED,Engin A

更新日期：2020-08-01 00:00:00

abstract：:The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutat...

journal_title：Environmental toxicology and pharmacology

authors： Kavitha P,Rao JV

更新日期：2008-09-01 00:00:00

abstract：:The ecological risks posed by two β-diketone antibiotics (DKAs, enrofloxacin, ENR and ciprofloxacin, CPX), characterized by their long persistence in aqueous environments and known deleterious effect on model organisms such as zebrafish were analysed using Rhinella arenarum larvae. Sublethal tests were conducted using...

journal_title：Environmental toxicology and pharmacology

authors： Peltzer PM,Lajmanovich RC,Attademo AM,Junges CM,Teglia CM,Martinuzzi C,Curi L,Culzoni MJ,Goicoechea HC

更新日期：2017-04-01 00:00:00

abstract：:Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

journal_title：Environmental toxicology and pharmacology

authors： Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

更新日期：2012-09-01 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

journal_title：Environmental toxicology and pharmacology

authors： Kwong SP,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

journal_title：Environmental toxicology and pharmacology

authors： Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

更新日期：1996-07-15 00:00:00

abstract：:Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...

journal_title：Environmental toxicology and pharmacology

authors： Zhang X,Xiong J,Jiao Y,Wang G,Zuo Z

更新日期：2010-05-01 00:00:00