Abstract：
:The recovery effect of chlorpyrifos (CPF) on antioxidant enzymes, locomotor behaviour and the target enzyme acetylcholinesterase (AChE) interaction were studied after exposure to 297μgL(-1) (LC(50) for 96h) in mosquito fish, Gambusia affinis. Activities of the antioxidant enzymes-superoxide dismutase, catalase, glutathione reductase in viscera, and AChE in brain were inhibited at 96h of exposure. However, induction in lipid peroxidation was observed. The antioxidant levels were restored to near control by 16-18 days. Similarly, swimming speed and AChE were also recovered but comparatively needs longer period. In vitro AChE study indicated that CPF alters the apparent K(m) values, resulting in a competitive type of inhibition and the inhibitory constant K(i) was found to be 4.57×10(-4)M. The results showed that the organophosphate CPF besides its inhibitory effect on target enzyme AChE also inhibits antioxidant enzymes, which can be used as biomarkers in the pesticide-contaminated aquatic streams.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Kavitha P,Rao JVdoi
10.1016/j.etap.2008.03.010subject
Has Abstractpub_date
2008-09-01 00:00:00pages
192-8issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(08)00053-7journal_volume
26pub_type
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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更新日期：2013-03-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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更新日期：2017-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2007.10.018
更新日期：2008-03-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.10.019
更新日期：2014-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2008.06.002
更新日期：2008-11-01 00:00:00
abstract：:N-Phenyl benzamides are potent antibacterial agents. They are active against both Gram-positive and Gram-negative bacteria. The Gram-positive bacteria have strong and thick cell wall while the Gram-negative bacterial have thin and permeable cell wall. The DFT based QSAR reveals that molecular weight and total energy s...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2008.01.005
更新日期：2008-09-01 00:00:00
