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Food flavor cinnamaldehyde-induced biochemical and histological changes in the kidney of male albino wistar rat.

Abstract：

:Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities of renal, serum and urinary enzymes. CNMA-induced glucosuria in these rats was accompanied by marked proteinuria and creatinuria. Increased serum blood urea nitrogen and serum creatinine and decreased serum protein and glucose levels were observed in these rats. Thus, CNMA at the dose of 73.5mg/kg body weight/day for 90 days exert its effect on kidney of male albino wistar rat and its effect is time and dose dependent.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Gowder SJ,Devaraj H

doi

10.1016/j.etap.2008.02.002

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

68-74

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(08)00023-9

journal_volume

26

pub_type

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