Purification and characterization of antioxidant components from the fruiting bodies of Pleurotus abalonus including 9-beta-d-ribofuranosidoadenine, 5'-deoxy-5'-(methylthio)adenosine, and a triterpenoid.

Abstract:

:Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-beta-d-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid complex from P. abalonus. Different antioxidant activities including inhibitory effects on hemolysis and lipid peroxidation in brain and kidney homogenates as well as significant synergistic effect on scavenging of hydroxyl radicals were demonstrated, which lays a foundation for the development of P. abalonus as a natural antioxidant applied in medicine.

authors

Zhang YN,Song M,Ng TB,Zhao L,Liu F

doi

10.1016/j.etap.2013.06.007

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

689-696

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(13)00139-7

journal_volume

36

pub_type

杂志文章
  • Sociodemographic aspects of human susceptibility to toxic chemicals: Do class and race matter for realistic risk assessment?

    abstract::Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)10020-5

    authors: Sexton K

    更新日期:1997-12-01 00:00:00

  • Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens.

    abstract::Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35day...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.07.011

    authors: Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

    更新日期:2017-09-01 00:00:00

  • Effects of acute exposure to WIFI signals (2.45GHz) on heart variability and blood pressure in Albinos rabbit.

    abstract::Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.08.015

    authors: Saili L,Hanini A,Smirani C,Azzouz I,Azzouz A,Sakly M,Abdelmelek H,Bouslama Z

    更新日期:2015-09-01 00:00:00

  • The analysis of the possibility of using biological tests for assessment of toxicity of leachate from an active municipal landfill.

    abstract::One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2019.01.013

    authors: Przydatek G

    更新日期:2019-04-01 00:00:00

  • Effect of α-lipoic acid on spatial memory and structural integrity of developing hippocampal neurons in rats subjected to sodium arsenite exposure.

    abstract:BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103323

    authors: Dixit S,Mehra RD,Dhar P

    更新日期:2020-04-01 00:00:00

  • Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.

    abstract::This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.10.019

    authors: Jiang P,Sheng YC,Chen YH,Ji LL,Wang ZT

    更新日期:2014-11-01 00:00:00

  • Three components of cigarette smoke altered the growth and apoptosis of metastatic colon cancer cells via inducing the synthesis of reactive oxygen species and endoplasmic reticulum stress.

    abstract::Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2016.05.016

    authors: Lee HM,Kim CW,Hwang KA,Choi DW,Choi KC

    更新日期:2016-07-01 00:00:00

  • Changes of respiratory system in mice exposed to PM4.0 or TSP from exhaust gases of combustion of cashew nut shell.

    abstract::Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.08.020

    authors: Josino JB,Serra DS,Gomes MDM,Araújo RS,de Oliveira MLM,Cavalcante FSÁ

    更新日期:2017-12-01 00:00:00

  • Terephthalic acid occupational exposure and its effect on organ functions in fiber workers.

    abstract:OBJECTIVES:: To investigate the exposure to terephthalic acid (TPA), and to evaluate it's effects on organ function including the potential risk factors for uroliths and bladder tumor to TPA. METHODS:: Exposure-response modeling was carried out in a cohort of 141 TPA exposure workers and three subgroups were classifie...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2005.01.007

    authors: Dai G,Cui L,Song L,Gong N,Chen J,Zhao R,Wang S,Chang HC,Wang X

    更新日期:2005-07-01 00:00:00

  • 4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.

    abstract::4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2018.07.010

    authors: Huang S,Cao S,Zhou T,Kong L,Liang G

    更新日期:2018-09-01 00:00:00

  • The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage.

    abstract::We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.12.011

    authors: Chen J,Song M,Li Y,Zhang Y,Taya K,Li C

    更新日期:2016-01-01 00:00:00

  • Protein S-thiolation and depletion of intracellular glutathione in skin fibroblasts exposed to various sources of oxidative stress.

    abstract::It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2005.12.007

    authors: Ashraf SS,Galadari S,Patel M

    更新日期:2006-07-01 00:00:00

  • Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction.

    abstract::The existing hazard of joint mycotoxin exposure of animals/humans and the significance of masked mycotoxins in foods or feeds and their respective contributions to the development of some food born mycotoxicoses is briefly reviewed. The importance of joint mycotoxin interaction in the complex etiology of some foodborn...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2015.01.022

    authors: Stoev SD

    更新日期:2015-03-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes.

    abstract::Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(98)00040-4

    authors: Wörner W,Schrenk D

    更新日期:1998-12-01 00:00:00

  • Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.

    abstract::The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated. PFOA and PFOS promoted IgE-mediated release of granule components of RBL2H3 cells at 10-300μM. At low concentrations (<30μM), the fluorosur...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2009.12.009

    authors: Yamaki K,Yoshino S

    更新日期:2010-03-01 00:00:00

  • The metabolic effects of diuron in the rat liver.

    abstract::A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.06.024

    authors: da Silva Simões M,Bracht L,Parizotto AV,Comar JF,Peralta RM,Bracht A

    更新日期:2017-09-01 00:00:00

  • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites.

    abstract::Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.06.001

    authors: Sarma SN,Kim YJ,Ryu JC

    更新日期:2011-09-01 00:00:00

  • Application of the yeast-based reporter gene bioassay for the assessment of estrogenic activity in cow's milk from Poland.

    abstract::Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.09.022

    authors: Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

    更新日期:2015-11-01 00:00:00

  • Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats.

    abstract::The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.04.015

    authors: Lingabathula H,Yellu N

    更新日期:2017-06-01 00:00:00

  • Oxidative stress, protein carbonylation and heat shock proteins in the black tiger shrimp, Penaeus monodon, following exposure to endosulfan and deltamethrin.

    abstract::The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2009.05.006

    authors: Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

    更新日期:2009-09-01 00:00:00

  • GS-2, a pyrazolo[1,5-a]indole derivative with inhibitory activity of topoisomerases, exerts its potent cytotoxic activity by ROS generation.

    abstract::Pyrazolo[1,5-a]indole derivatives, a new type of topoisomerase (topo) inhibitor, demonstrate a broad spectrum of antitumor activities. However, the mechanism underlying the induced cytotoxicity remains unclear. In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast can...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.09.019

    authors: Ji YY,Zhu YM,Wang JW

    更新日期:2013-11-01 00:00:00

  • Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.

    abstract::This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.08.019

    authors: Guo W,Shi X,Wang W,Zhang W,Li J

    更新日期:2014-11-01 00:00:00

  • Chemo-preventive effect of crocin against experimentally-induced hepatocarcinogenesis via regulation of apoptotic and Nrf2 signaling pathways.

    abstract::The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103494

    authors: Elsherbiny NM,Eisa NH,El-Sherbiny M,Said E

    更新日期:2020-11-01 00:00:00

  • Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens.

    abstract::Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series of osteolathyrogens, i.e. chemicals that inhibit cros...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2003.08.002

    authors: Dawson DA,Scott BD,Ellenberger MJ,Pöch G,Rinaldi AC

    更新日期:2004-03-01 00:00:00

  • Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.

    abstract::Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver. Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and other active components and have high antioxidant capacities. We investigated the effect of BB pretreatment...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.05.014

    authors: Bingül İ,Başaran-Küçükgergin C,Tekkeşin MS,Olgaç V,Doğru-Abbasoğlu S,Uysal M

    更新日期:2013-09-01 00:00:00

  • Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity.

    abstract::Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2007.07.002

    authors: Ghaly IS,Said A,Abdel-Wahhab MA

    更新日期:2008-01-01 00:00:00

  • Paraquat and temperature affect nonspecific immune response of Colossoma macropomum.

    abstract::This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.11.010

    authors: Salazar-Lugo R,Estrella A,Oliveros A,Rojas-Villarroel E,Villalobos de B L,Lemus M

    更新日期:2009-05-01 00:00:00

  • Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis.

    abstract::Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.07.014

    authors: Karthikkumar V,Sivagami G,Vinothkumar R,Rajkumar D,Nalini N

    更新日期:2012-11-01 00:00:00

  • S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency.

    abstract::A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.12.006

    authors: Thayumanavan P,Loganathan C,Iruthayaraj A,Poomani K,Nallaiyan S

    更新日期:2018-03-01 00:00:00

  • Altered p53 response and enhanced transgenerational transmission of carcinogenic risk upon exposure of mice to betel nut.

    abstract::Alteration of p53 protein level, and possible mutation of the p53 gene during carcinogenesis in mice exposed chronically (P) and transgenerationally to 2mg/ml aqueous extract of betel nut (AEBN) in drinking water, were studied. Exons 5 and 7 of the p53 gene were not mutated under both chronic and transgenerational exp...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.09.003

    authors: Choudhury Y,Sharan RN

    更新日期:2009-01-01 00:00:00