Abstract:
:Although Pleurotus abalonus is a well-known edible mushroom in Asia, there is a dearth of information on its antioxidant activity. The present report is the first one focused on the purification and characterization of 9-beta-d-ribofuranosidoadenine (ADO), 5'-deoxy-5'-(methylthio) adenosine (MTA) and a triterpenoid complex from P. abalonus. Different antioxidant activities including inhibitory effects on hemolysis and lipid peroxidation in brain and kidney homogenates as well as significant synergistic effect on scavenging of hydroxyl radicals were demonstrated, which lays a foundation for the development of P. abalonus as a natural antioxidant applied in medicine.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Zhang YN,Song M,Ng TB,Zhao L,Liu Fdoi
10.1016/j.etap.2013.06.007subject
Has Abstractpub_date
2013-09-01 00:00:00pages
689-696issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(13)00139-7journal_volume
36pub_type
杂志文章abstract::Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(97)10020-5
更新日期:1997-12-01 00:00:00
abstract::Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35day...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.07.011
更新日期:2017-09-01 00:00:00
abstract::Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2015.08.015
更新日期:2015-09-01 00:00:00
abstract::One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2019.01.013
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2020.103323
更新日期:2020-04-01 00:00:00
abstract::This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2014.10.019
更新日期:2014-11-01 00:00:00
abstract::Cigarette smoke (CS) is a well-known risk factor for carcinogenesis and has been found to be related to the occurrence and development of colon cancer. In this study, the effect of formaldehyde (FA), benzene (Bz), and isoprene (IP), which are included in main components of CS, on cell viability and apoptosis of SW620 ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2016.05.016
更新日期:2016-07-01 00:00:00
abstract::Air pollution is a topic discussed all over the world and the search for alternatives to reduce it is of great interest to many researchers. The use of alternative energy sources and biofuels seems to be the environmentally safer solution. In this work, the deleterious effects on the respiratory system of mice exposed...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.08.020
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:: To investigate the exposure to terephthalic acid (TPA), and to evaluate it's effects on organ function including the potential risk factors for uroliths and bladder tumor to TPA. METHODS:: Exposure-response modeling was carried out in a cohort of 141 TPA exposure workers and three subgroups were classifie...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2005.01.007
更新日期:2005-07-01 00:00:00
abstract::4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We a...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2018.07.010
更新日期:2018-09-01 00:00:00
abstract::We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2015.12.011
更新日期:2016-01-01 00:00:00
abstract::It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2005.12.007
更新日期:2006-07-01 00:00:00
abstract::The existing hazard of joint mycotoxin exposure of animals/humans and the significance of masked mycotoxins in foods or feeds and their respective contributions to the development of some food born mycotoxicoses is briefly reviewed. The importance of joint mycotoxin interaction in the complex etiology of some foodborn...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.etap.2015.01.022
更新日期:2015-03-01 00:00:00
abstract::Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(98)00040-4
更新日期:1998-12-01 00:00:00
abstract::The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated. PFOA and PFOS promoted IgE-mediated release of granule components of RBL2H3 cells at 10-300μM. At low concentrations (<30μM), the fluorosur...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2009.12.009
更新日期:2010-03-01 00:00:00
abstract::A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.06.024
更新日期:2017-09-01 00:00:00
abstract::Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2011.06.001
更新日期:2011-09-01 00:00:00
abstract::Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2015.09.022
更新日期:2015-11-01 00:00:00
abstract::The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.04.015
更新日期:2017-06-01 00:00:00
abstract::The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2009.05.006
更新日期:2009-09-01 00:00:00
abstract::Pyrazolo[1,5-a]indole derivatives, a new type of topoisomerase (topo) inhibitor, demonstrate a broad spectrum of antitumor activities. However, the mechanism underlying the induced cytotoxicity remains unclear. In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast can...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.09.019
更新日期:2013-11-01 00:00:00
abstract::This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2014.08.019
更新日期:2014-11-01 00:00:00
abstract::The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2020.103494
更新日期:2020-11-01 00:00:00
abstract::Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series of osteolathyrogens, i.e. chemicals that inhibit cros...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2003.08.002
更新日期:2004-03-01 00:00:00
abstract::Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver. Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and other active components and have high antioxidant capacities. We investigated the effect of BB pretreatment...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.05.014
更新日期:2013-09-01 00:00:00
abstract::Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2007.07.002
更新日期:2008-01-01 00:00:00
abstract::This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2008.11.010
更新日期:2009-05-01 00:00:00
abstract::Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2012.07.014
更新日期:2012-11-01 00:00:00
abstract::A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.12.006
更新日期:2018-03-01 00:00:00
abstract::Alteration of p53 protein level, and possible mutation of the p53 gene during carcinogenesis in mice exposed chronically (P) and transgenerationally to 2mg/ml aqueous extract of betel nut (AEBN) in drinking water, were studied. Exons 5 and 7 of the p53 gene were not mutated under both chronic and transgenerational exp...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2008.09.003
更新日期:2009-01-01 00:00:00