当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency.

S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency.

Abstract：

:A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GGT, ALP and LDH) and bilirubin in the blood circulation. Such protective effect of SAG resulted in preservation of liver function observed as normal level of total protein and albumin in plasma as well as inhibition of dyslipidemia in liver. In addition, in silico analysis has proved that SAG has strong affinity with the amino acids present in active site of the human cytochrome P450 2E1 and 3A4. Three important mechanisms provided by SAG such as scavenging of reactive oxidants, replenishing of endogenous antioxidants (SOD, catalase, GPx, GSH and vitamin C) and protection of mitochondrial function (oxidative phosphorylation complex activities) are involved in the optimal function of liver against CCl4-toxicity.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Thayumanavan P,Loganathan C,Iruthayaraj A,Poomani K,Nallaiyan S

doi

10.1016/j.etap.2017.12.006

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

21-28

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(17)30327-7

journal_volume

58

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo mode

    abstract：:Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.08.015

    authors： Cocci P,Mozzicafreddo M,Angeletti M,Mosconi G,Palermo FA

    更新日期：2017-10-01 00:00:00

  • Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

    abstract：:The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were anal...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.02.004

    authors： Ruíz-Vera T,Ochoa-Martínez ÁC,Zarazúa S,Carrizales-Yáñez L,Pérez-Maldonado IN

    更新日期：2019-04-01 00:00:00

  • Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

    abstract：:Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.12.016

    authors： Wang W,Chen QF,Li QB,Wu YB,Chen K,Chen B,Wen JM

    更新日期：2014-03-01 00:00:00

  • Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3.

    abstract：:Cadmium (Cd) is a major pollutant of environment. It can be fatal to human. In spite of bulk of research and literatures, the mechanism of a fatality against human is still not understood completely. Toxic and carcinogenic effects of Cd in rodents and humans are well known. However, effects of Cd on induction of apopt...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.09.006

    authors： Al-Assaf AH,Alqahtani AM,Alshatwi AA,Syed NA,Shafi G,Hasan TN

    更新日期：2013-11-01 00:00:00

  • Effects of atrazine and chlorpyrifos on activity and transcription of glutathione S-transferase in common carp (Cyprinus carpio L.).

    abstract：:Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.014

    authors： Xing H,Wang X,Sun G,Gao X,Xu S,Wang X

    更新日期：2012-03-01 00:00:00

  • Blood selenium concentration in a selected population of children inhabiting industrial regions in Upper Silesia (Poland).

    abstract：PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.06.005

    authors： Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

    更新日期：2012-09-01 00:00:00

  • Elevation of serum 17-beta-estradiol in channel catfish following injection of 17-beta-estradiol, ethynyl estradiol, estrone, estriol and estradiol-17-beta-glucuronide.

    abstract：:17-beta-Estradiol is naturally converted in numerous organisms to various derivatives/metabolites, which may be excreted from the organism into its immediate external environment. There is a paucity of data regarding the biological effects of these derivatives/metabolites on aquatic organisms. Male channel catfish (20...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(01)00062-x

    authors： Tilton F,Benson WH,Schlenk D

    更新日期：2001-03-01 00:00:00

  • Effects of Mandrax and Cannabis on the cellular function of chick embryonic neurons.

    abstract：:Cannabis and Mandrax abuse is unique to South Africa; and most research has focused on the socio-economic impact rather than the adverse effects on the developing brain. Therefore, the aim of this study is to determine the effects of Mandrax and Cannabis alone and in combination on the developing brain by using primar...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2006.07.005

    authors： da Silva AA,Bester MJ,Pretorius E

    更新日期：2007-01-01 00:00:00

  • Common differentially expressed proteins were found in mouse cleft palate models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid.

    abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103270

    authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

    更新日期：2019-11-01 00:00:00

  • The genotoxicity of diaveridine and trimethoprim.

    abstract：:We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the um...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)00026-4

    authors： Ono T,Sekiya T,Takahashi Y,Sasaki YF,Izumiyama F,Nishidate E,Tsuda S,Ohta T

    更新日期：1997-09-01 00:00:00

  • Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (Danio rerio) livers.

    abstract：:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, r...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.018

    authors： Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Y

    更新日期：2017-04-01 00:00:00

  • Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts.

    abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.11.023

    authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

    更新日期：2016-03-01 00:00:00

  • Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.

    abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.10.002

    authors： Chung JW,Shin JE,Han KW,Ahn JH,Kim YJ,Park JW,So HS

    更新日期：2011-01-01 00:00:00

  • Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction.

    abstract：:The existing hazard of joint mycotoxin exposure of animals/humans and the significance of masked mycotoxins in foods or feeds and their respective contributions to the development of some food born mycotoxicoses is briefly reviewed. The importance of joint mycotoxin interaction in the complex etiology of some foodborn...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2015.01.022

    authors： Stoev SD

    更新日期：2015-03-01 00:00:00

  • Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai.

    abstract：:Pimpinella brachycarpa (Kom.) Nakai (PB) is one of the most favored edible greens grown in Asian regions. In our previously study, we found PB extract had antioxidant effects in vitro. In the present study, an EtOAc soluble extract (PBet) was isolated from PB. Then the antioxidant properties at cellular level, phytoch...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.05.015

    authors： Lu J,Qian W,Xu L,Huang G,Cong W,Wang Z,Deng X,Wang D,Guan S

    更新日期：2012-09-01 00:00:00

  • Effects of infrasound on hippocampus-dependent learning and memory in rats and some underlying mechanisms.

    abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.04.011

    authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

    更新日期：2009-09-01 00:00:00

  • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites.

    abstract：:Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.06.001

    authors： Sarma SN,Kim YJ,Ryu JC

    更新日期：2011-09-01 00:00:00

  • Dechlorination of PCB in the presence of plant nitrate reductase.

    abstract：:The dechlorination of PCB, specifically the noncoplanar congener PCB 153, has been observed in the presence of a crude nitrate reductase extract from Medicago sativa leaves. These observations were further confirmed using a commercially available and pure nitrate reductase from Zea mays. The presence of nitrate reduct...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.10.009

    authors： Magee KD,Michael A,Ullah H,Dutta SK

    更新日期：2008-03-01 00:00:00

  • A focus on the human lens in vitro.

    abstract：:The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.07.012

    authors： Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期：2006-02-01 00:00:00

  • Altered expression profiles of microRNAs upon arsenic exposure of human umbilical vein endothelial cells.

    abstract：:Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.05.003

    authors： Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

    更新日期：2012-09-01 00:00:00

  • Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.

    abstract：:Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological eff...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.05.022

    authors： Wu H,Zhong M,Lu Z,Shan X,Li F,Ji C,Cong M

    更新日期：2018-07-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes an Ah receptor-dependent and ARNT-independent increase in membrane levels and activity of p60(Src).

    abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to affect various cellular activities including growth factor signal transduction, hormone responses, and cell differentiation. The purpose of this study was to examine more closely the very early effects of TCDD on protein tyrosine kinase activity, specifically p60(...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)00016-1

    authors： Blankenship A,Matsumura F

    更新日期：1997-07-01 00:00:00

  • Deferasirox-induced cytogenetic responses.

    abstract：:Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.02.001

    authors： Arslan M,Ila HB

    更新日期：2015-03-01 00:00:00

  • Erythrocyte antioxidants enzymes imbalance following subcutaneous pyrethroid treatments in rats of different sex.

    abstract：:Permethrin and deltamethrin are insecticides used all over the world in agriculture to control pests. The aim of this work is to investigate the effects of subcutaneous permethrin and/or deltamethrin treatments on erythrocyte antioxidant enzymes activity in rats of different sex. The results obtained show that permeth...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.04.005

    authors： Chargui I,Falcioni ML,Cheikh HB,Gabbianelli R

    更新日期：2010-09-01 00:00:00

  • Glyphosate induces cardiovascular toxicity in Danio rerio.

    abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.08.010

    authors： Roy NM,Ochs J,Zambrzycka E,Anderson A

    更新日期：2016-09-01 00:00:00

  • Association of arsenic exposure with smoking, alcohol, and caffeine consumption: data from NHANES 2005-2010.

    abstract：:Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.01.011

    authors： Jain RB

    更新日期：2015-03-01 00:00:00

  • Effects of acute exposure to WIFI signals (2.45GHz) on heart variability and blood pressure in Albinos rabbit.

    abstract：:Electrocardiogram and arterial pressure measurements were studied under acute exposures to WIFI (2.45GHz) during one hour in adult male rabbits. Antennas of WIFI were placed at 25cm at the right side near the heart. Acute exposure of rabbits to WIFI increased heart frequency (+22%) and arterial blood pressure (+14%). ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.08.015

    authors： Saili L,Hanini A,Smirani C,Azzouz I,Azzouz A,Sakly M,Abdelmelek H,Bouslama Z

    更新日期：2015-09-01 00:00:00

  • Cell metabolic changes of porphyrins and superoxide anions by anthracene and benzo(a)pyrene.

    abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.05.002

    authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

    更新日期：2008-09-01 00:00:00

  • A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida.

    abstract：:Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor inc...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.06.007

    authors： Zhang W,Liu K,Chen L,Chen L,Lin K,Fu R

    更新日期：2014-07-01 00:00:00

  • Protective effect of a marine polyphenol, dieckol against carbon tetrachloride-induced acute liver damage in mouse.

    abstract：:In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mou...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.02.013

    authors： Kang MC,Kang SM,Ahn G,Kim KN,Kang N,Samarakoon KW,Oh MC,Lee JS,Jeon YJ

    更新日期：2013-05-01 00:00:00