2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes an Ah receptor-dependent and ARNT-independent increase in membrane levels and activity of p60(Src).

abstract：:The aims of the present study were to verify the suitability of short-term in situ test with the neotropical fish Prochilodus lineatus and to evaluate from a set of biochemical and physiological biomarkers the ones which could work as sensitivity tools for the environmental quality assessment. In situ tests were carri...

journal_title：Environmental toxicology and pharmacology

authors： Camargo MM,Martinez CB

更新日期：2006-01-01 00:00:00

abstract：:Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

journal_title：Environmental toxicology and pharmacology

authors： Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

更新日期：2020-04-01 00:00:00

abstract：:To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) ...

journal_title：Environmental toxicology and pharmacology

authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:: To investigate the exposure to terephthalic acid (TPA), and to evaluate it's effects on organ function including the potential risk factors for uroliths and bladder tumor to TPA. METHODS:: Exposure-response modeling was carried out in a cohort of 141 TPA exposure workers and three subgroups were classifie...

journal_title：Environmental toxicology and pharmacology

authors： Dai G,Cui L,Song L,Gong N,Chen J,Zhao R,Wang S,Chang HC,Wang X

更新日期：2005-07-01 00:00:00

abstract：:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investig...

journal_title：Environmental toxicology and pharmacology

authors： Niu Z,Zhang W,Gu X,Zhang X,Qi Y,Zhang Y

更新日期：2016-07-01 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

journal_title：Environmental toxicology and pharmacology

authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

更新日期：2008-09-01 00:00:00

abstract：:Pimpinella brachycarpa (Kom.) Nakai (PB) is one of the most favored edible greens grown in Asian regions. In our previously study, we found PB extract had antioxidant effects in vitro. In the present study, an EtOAc soluble extract (PBet) was isolated from PB. Then the antioxidant properties at cellular level, phytoch...

journal_title：Environmental toxicology and pharmacology

authors： Lu J,Qian W,Xu L,Huang G,Cong W,Wang Z,Deng X,Wang D,Guan S

更新日期：2012-09-01 00:00:00

abstract：:Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...

journal_title：Environmental toxicology and pharmacology

authors： Karthikkumar V,Sivagami G,Vinothkumar R,Rajkumar D,Nalini N

更新日期：2012-11-01 00:00:00

abstract：:Styrene exposure and color vision for 108 workers (21-65 years) was studied at Swedish reinforced plastic plants. Acute exposure was measured at work. Data on past exposures and personal background data were collected by questionnaire. Current exposure varied between 0.3 and 96mg/m(3). Cumulative past exposures varied...

journal_title：Environmental toxicology and pharmacology

authors： Iregren A,Johnson AC,Nylén P

更新日期：2005-05-01 00:00:00

abstract：:The aim of this work was to evaluate the Ascidian Embryo Teratogenicity assay (AET) as new alternative invertebrate model to test the developmental effects of the co-exposure to ethanol and fluconazole. Ciona intestinalis embryos were exposed to the azolic fungicide fluconazole, (FLUCO, 7.8-250μM), to ethanol (Eth, 0....

journal_title：Environmental toxicology and pharmacology

authors： Battistoni M,Mercurio S,Ficetola GF,Metruccio FC,Menegola E,Pennati R

更新日期：2018-01-01 00:00:00

abstract：:Taurine (TAU) has protective effects on experimental liver fibrosis. The present study investigates whether benefits of TAU are mediated through attenuation of oxidative and nitrosative stresses. Liver fibrosis was induced in male Wistar rats by simultaneous administration of iron (0.5%, w/w) and ethanol (6g/kg/day) f...

journal_title：Environmental toxicology and pharmacology

authors： Devi SL,Anuradha CV

更新日期：2010-03-01 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs) with a length of 200nt-100kb lacking a significant open reading frame. The study of lncRNAs is a newly established field, due in part to their capability to act as the novel biomarkers in disease. A growing body of research shows that lncRNAs ma...

journal_title：Environmental toxicology and pharmacology

authors： Chen S,Liang H,Yang H,Zhou K,Xu L,Liu J,Lai B,Song L,Luo H,Peng J,Liu Z,Xiao Y,Chen W,Tang H

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to evaluate cytogenotoxic effects of bee venom to human lymphocytes and take a look into the mechanisms behind them. Bee venom was tested in concentrations ranging from 0.1μg/ml to 20μg/ml over different lengths of time. Cell viability, type of the cell death, and morphological alterations we...

journal_title：Environmental toxicology and pharmacology

authors： Gajski G,Garaj-Vrhovac V

更新日期：2011-09-01 00:00:00

abstract：:Ulcerative colitis (UC) is a disease of increased worldwide prevalence. UC progression is associated with serious complications that leave the patient with considerable health burdens. Nifuroxazide is an oral nitrofuran antibiotic used as antidiarrheal medication. The current study places an emphasis on investigating ...

journal_title：Environmental toxicology and pharmacology

authors： El-Far YM,Elsherbiny NM,El-Shafey M,Said E

更新日期：2020-10-01 00:00:00

abstract：:We previously observed that nonylphenol (NP) exposure during development resulted in increases in body weight and hyperadrenalism in adult male offspring. The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11...

journal_title：Environmental toxicology and pharmacology

authors： Chang LL,Wun WS,Wang PS

更新日期：2016-06-01 00:00:00

abstract：:The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...

journal_title：Environmental toxicology and pharmacology

authors： Pivčević B,Zaja R

更新日期：2006-11-01 00:00:00

abstract：:The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis "Tomentosa", at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean ...

journal_title：Environmental toxicology and pharmacology

authors： Liu M,Yang C,Zou W,Guan X,Zheng W,Lai L,Fang S,Cai S,Su W

更新日期：2011-05-01 00:00:00

abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

journal_title：Environmental toxicology and pharmacology

authors： Kwong SP,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

journal_title：Environmental toxicology and pharmacology

authors： Wörner W,Schrenk D

更新日期：1998-12-01 00:00:00

abstract：:To investigate the effect of infrasound on the hippocampus-dependent spatial learning and memory as well as its underlying mechanisms, we measured the changes of cognitive abilities, brain-derived neurotrophic factor (BDNF)-tyrosine kinase receptor B (TrkB) signal transduction pathway and neurogenesis in the hippocamp...

journal_title：Environmental toxicology and pharmacology

authors： Yuan H,Long H,Liu J,Qu L,Chen J,Mou X

更新日期：2009-09-01 00:00:00

abstract：:In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...

journal_title：Environmental toxicology and pharmacology

authors： Kamal A,Malik RN,Fatima N,Rashid A

更新日期：2012-07-01 00:00:00

abstract：:Emamectin benzoate (EB) is an avermectin insecticide used extensively in pest control on vegetable and field crops. Few studies have been done for evaluating adverse effects of EB. In the current study, we evaluated the toxic effects of EB on male rats and the possible ameliorative role of fennel essential oil (FEO). ...

journal_title：Environmental toxicology and pharmacology

authors： El-Sheikh el-SA,Galal AA

更新日期：2015-05-01 00:00:00

abstract：:To identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured b...

journal_title：Environmental toxicology and pharmacology

authors： Ma L,Liang B,Yang Y,Chen L,Liu Q,Zhang A

更新日期：2020-04-01 00:00:00

abstract：:Metabolic activity, particularly conjugation, was examined in fish by analyzing pyrene (a four-ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry (MS) system, and kinetic analysis of conjugation enzymes. Fourteen f...

journal_title：Environmental toxicology and pharmacology

authors： Ikenaka Y,Oguri M,Saengtienchai A,Nakayama SMM,Ijiri S,Ishizuka M

更新日期：2013-09-01 00:00:00

abstract：:Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

journal_title：Environmental toxicology and pharmacology

authors： Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

更新日期：2012-09-01 00:00:00

abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

journal_title：Environmental toxicology and pharmacology

authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

更新日期：2019-11-01 00:00:00

abstract：:To explore the effects of microcystin-LR (MC-LR), a hepatotoxin, on the incidence of liver lipid metabolism abnormality, and the potential molecular mechanisms of action, healthy male Balb/c mice were intraperitoneally injected with MC-LR at doses of 0, 5, 10, and 20 μg/kg/d for 14 days. Hepatic histopathology and ser...

journal_title：Environmental toxicology and pharmacology

authors： Qin W,Zhang X,Yang L,Xu L,Zhang Z,Wu J,Wang Y

更新日期：2015-07-01 00:00:00

abstract：:In the new drugs, greater than 90 % of active pharmaceutical ingredients (APIs) or marketed drugs have poor solubility and bioavailability, which restrict the development of pharmaceutical preparations. The use of crystalline molecular complexes (CMCs) involving API and biocompatible precursors to improve solubility h...

journal_title：Environmental toxicology and pharmacology

authors： Wang H,Li S,Liu L,Wang J,Wang Y,Guo W

更新日期：2020-11-01 00:00:00

abstract：:The effects of oral administration of tamoxifen, 17α-ethynylestradiol (EE2), flutamide, and methyltestosterone (MT), on plasma vitellogenin levels of male and female medaka were investigated. Medaka were fed diets containing different concentrations of these chemicals for 7 days, and these plasma vitellogenin levels w...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Ikeda R,Hasan Q,Morita Y,Tamiya E

更新日期：2004-05-01 00:00:00