Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai.

abstract：:Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal care and household products. The structural similarity of triclosan to thyroid hormones and recent studies demonstrating activation of the human pregnane X receptor (PXR) a...

journal_title：Environmental toxicology and pharmacology

authors： Crofton KM,Paul KB,Devito MJ,Hedge JM

更新日期：2007-09-01 00:00:00

abstract：:It is well established that oxidative stress plays a central role in the onset and progression of over a 100 different diseases. Recently, a growing body of evidence has shown that chemicals/agents as diverse as aromatic compounds, UV radiation and redox-active metals also generate oxy-radicals in vivo and lead to cel...

journal_title：Environmental toxicology and pharmacology

authors： Ashraf SS,Galadari S,Patel M

更新日期：2006-07-01 00:00:00

abstract：:Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, at...

journal_title：Environmental toxicology and pharmacology

authors： Wu Z,Bai L,Tu R,Zhang L,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

更新日期：2020-05-01 00:00:00

abstract：:The features of organophosphate-induced brain injuries were investigated. Rats were poisoned intraperitoneally with 9 mg/kg (1.8 LD(50)) of diisopropylfluorophosphate. Pyridostigmine bromide (0.1 mg/kg) and atropine methylnitrate (20 mg/kg), which are centrally inactive, were pre-treated intramuscularly to reduce the ...

journal_title：Environmental toxicology and pharmacology

authors： Kim YB,Hur GH,Shin S,Sok DE,Kang JK,Lee YS

更新日期：1999-04-01 00:00:00

abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

journal_title：Environmental toxicology and pharmacology

authors： Kwong SP,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Cannabis and Mandrax abuse is unique to South Africa; and most research has focused on the socio-economic impact rather than the adverse effects on the developing brain. Therefore, the aim of this study is to determine the effects of Mandrax and Cannabis alone and in combination on the developing brain by using primar...

journal_title：Environmental toxicology and pharmacology

authors： da Silva AA,Bester MJ,Pretorius E

更新日期：2007-01-01 00:00:00

abstract：:Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil po...

journal_title：Environmental toxicology and pharmacology

authors： Uwizeyimana H,Wang M,Chen W,Khan K

更新日期：2017-10-01 00:00:00

abstract：:Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...

journal_title：Environmental toxicology and pharmacology

authors： Zhang X,Xiong J,Jiao Y,Wang G,Zuo Z

更新日期：2010-05-01 00:00:00

abstract：:Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...

journal_title：Environmental toxicology and pharmacology

authors： Sexton K

更新日期：1997-12-01 00:00:00

abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

journal_title：Environmental toxicology and pharmacology

authors： Müller S,Schmid P,Schlatter C

更新日期：1998-08-04 00:00:00

abstract：:The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

journal_title：Environmental toxicology and pharmacology

authors： Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

更新日期：2011-03-01 00:00:00

abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

journal_title：Environmental toxicology and pharmacology

authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

更新日期：2009-03-01 00:00:00

abstract：:Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this st...

journal_title：Environmental toxicology and pharmacology

authors： Demir Y,Özaslan MS,Duran HE,Küfrevioğlu Öİ,Beydemir Ş

更新日期：2019-08-01 00:00:00

abstract：:The cytotoxicity of sodium nitroprusside (SNP) to the human endothelial cell line, ECV304, was studied. The cytotoxicity of SNP was primarily related to the liberation of nitric oxide (NO). S-nitroso-N-acetyl-d-penicillamine (SNAP), an NO donor, was highly toxic. Other degradation products of SNP either exerted much l...

journal_title：Environmental toxicology and pharmacology

authors： Babich H,Zuckerbraun HL,Ricklis AS,Blau L

更新日期：1998-03-01 00:00:00

abstract：:The present armamentarium of commercially available antidotes provides limited protection against the neurological effects of organophosphate exposure. Hence, there is an urgent need to design and develop molecules that can protect and reactivate inhibited-AChE in the central nervous system. Some natural compounds lik...

journal_title：Environmental toxicology and pharmacology

authors： Sharma R,Upadhyaya K,Gupta B,Ghosh KK,Tripathi RP,Musilek K,Kuca K

更新日期：2020-11-01 00:00:00

abstract：:The Brca1 and Brca2 tumor suppressor genes are involved in the maintenance of genomic integrity as they facilitate error free DNA repair. This study was designed to understand the role of Brca1 and Brca2 in betel nut (BN) induced chronic and transgenerational carcinogenesis in mice. Young male and female Swiss Albino ...

journal_title：Environmental toxicology and pharmacology

authors： Choudhury Y,Sharan RN

更新日期：2011-01-01 00:00:00

abstract：:Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated by a nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found that antidotes can be successfully applied to intoxicated daphnids. ...

journal_title：Environmental toxicology and pharmacology

authors： Vesela S,Kuca K,Jun D

更新日期：2008-05-01 00:00:00

abstract：:Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...

journal_title：Environmental toxicology and pharmacology

authors： Jung HY,Seo DW,Hong CO,Kim JY,Yang SY,Lee KW

更新日期：2015-01-01 00:00:00

abstract：:The effects of prenatal exposure to 75 and 150 ppm of carbon monoxide (CO) were evaluated in vitro on the electrical parameters of extensor digitorum longus muscle of newborn rats, by means of computerized two intracellular microelectrode technique. Within the first 2 months of postnatal life the muscles from offsprin...

journal_title：Environmental toxicology and pharmacology

authors： De Luca A,Pierno S,Tricarico D,Carratù MR,Cagiano R,Cuomo V,Camerino DC

更新日期：1996-10-15 00:00:00

abstract：:Juvenile Oncorhynchus mykiss (average weight: 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was ele...

journal_title：Environmental toxicology and pharmacology

authors： Lee JW,Deng DF,Lee J,Kim K,Jung HJ,Choe Y,Park SH,Yoon M

更新日期：2020-11-01 00:00:00

abstract：:Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results ...

journal_title：Environmental toxicology and pharmacology

authors： Wang Y,Hu Y,Wu Z,Su Y,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

更新日期：2019-02-01 00:00:00

abstract：:Quantitative structure - activity relationships (QSARs) which are obtained with a representation of the molecular architecture via simplified molecular input-line entry system (SMILES) are applied to build up predictive models of acute toxicity of pesticides towards Daphnia magna. The acute toxicity towards Daphnia ma...

journal_title：Environmental toxicology and pharmacology

authors： Cappelli CI,Toropov AA,Toropova AP,Benfenati E

更新日期：2020-11-01 00:00:00

abstract：:In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pr...

journal_title：Environmental toxicology and pharmacology

authors： Hou H,Zhou R,Li A,Li C,Li Q,Liu J,Jiang B

更新日期：2014-03-01 00:00:00

abstract：:Taurine (TAU) has protective effects on experimental liver fibrosis. The present study investigates whether benefits of TAU are mediated through attenuation of oxidative and nitrosative stresses. Liver fibrosis was induced in male Wistar rats by simultaneous administration of iron (0.5%, w/w) and ethanol (6g/kg/day) f...

journal_title：Environmental toxicology and pharmacology

authors： Devi SL,Anuradha CV

更新日期：2010-03-01 00:00:00

abstract：:Deltamethrin, is a commonly used pyrethroid pesticide. Vitamin E is a antioxidant that plays an important role in protecting cells against toxicity by inactivating free radicals generated following pesticides exposure. Therefore, it was evaluated whether deltamethrin induced histopathological changes and nuclear abnor...

journal_title：Environmental toxicology and pharmacology

authors： Kan Y,Cengiz EI,Ugurlu P,Yanar M

更新日期：2012-09-01 00:00:00

abstract：:Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three...

journal_title：Environmental toxicology and pharmacology

authors： Aroonvilairat S,Tangjarukij C,Sornprachum T,Chaisuriya P,Siwadune T,Ratanabanangkoon K

更新日期：2018-04-01 00:00:00

abstract：:Butyl benzyl phthalate (BBP) is commonly added during the manufacturing of plastics to increase flexibility and elasticity. However, BBP leaches off of plastic and environment presence has been detected in soil, groundwater and sediment potentially effecting organisms in the environment. Given the widespread uses of B...

journal_title：Environmental toxicology and pharmacology

authors： Roy NM,Zambrzycka E,Santangelo J

更新日期：2017-12-01 00:00:00

abstract：:Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions...

journal_title：Environmental toxicology and pharmacology

authors： Gramec Skledar D,Peterlin Mašič L

更新日期：2016-10-01 00:00:00

abstract：:A food allergen may be defined as a substance that reacts with IgE antibodies, induces allergic sensitisation or induces allergic reactions. Some allergens only induce allergic sensitisation but do not provoke symptoms, while others bind IgE but do not induce mast cell degranulation. There is no common structure that ...

journal_title：Environmental toxicology and pharmacology

authors： Aalberse RC

更新日期：1997-11-01 00:00:00

abstract：:This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...

journal_title：Environmental toxicology and pharmacology

authors： Zenick H,Costa DL

更新日期：1997-12-01 00:00:00