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Bisphenol A and its analogs: Do their metabolites have endocrine activity?

Abstract：

:Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions on endocrine activities of bisphenols, we conducted a systematic review of the literature. Knowledge about the metabolic pathways and enzymes involved in metabolic biotransformations is essential for understanding and predicting mechanisms of toxicity. Bisphenols are metabolized predominantly by the glucuronidation reaction, which is considered their most important detoxification pathway, as based on current knowledge, glucuronides do not have activity on endocrine receptors. In contrast, several oxidative metabolites of bisphenols with enhanced endocrine activities are presented, and these findings indicate that oxidative metabolites of bisphenols can still have endocrine activities in humans.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Gramec Skledar D,Peterlin Mašič L

doi

10.1016/j.etap.2016.09.014

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

182-199

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(16)30244-7

journal_volume

47

pub_type

杂志文章,评审

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