当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Pro-oxidative versus antioxidative reactions between Trolox and Cr(VI): The role of H(2)O(2).

Pro-oxidative versus antioxidative reactions between Trolox and Cr(VI): The role of H(2)O(2).

Abstract：

:The effect of the Vitamin E model compound Trolox in reactions with Cr(VI) in the presence or absence of hydrogen peroxide was investigated. The aim of this study was to establish and discuss potential Trolox-mediated pro-oxidative reactions. The importance of the Trolox:Cr(VI) ratio in the Cr(VI) reduction process was determined from the EPR spectra and DNA cleavage reactions. In the absence of hydrogen peroxide, reduction of Cr(VI) occurred with concomitant oxidation of Trolox to the phenoxyl radical. In the presence of hydrogen peroxide, Cr(V), produced by the reduction of Cr(VI), reduced hydrogen peroxide to the hydroxyl radical. The latter was detected by spin-trapping the methyl radical following reaction with N-methyl sulfoxide. During Cr(VI) reduction with Trolox, DNA single- or double-strand breaks due to Trolox radical formation were not observed. Relaxed DNA appeared only when H(2)O(2) was added to Trolox/Cr(VI) mixtures most probably due to hydroxyl radical formation during the redox cycling of Cr(V/IV)-species. Fenton-like reactions do not play a significant role in the Trolox/Cr(VI) system in the absence of added H(2)O(2).

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Poljšak B,Gazdag Z,Pesti M,Jenko-Brinovec S,Belagyi J,Plesničar S,Raspor P

doi

10.1016/j.etap.2005.11.004

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

15-9

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(05)00203-6

journal_volume

22

pub_type

杂志文章

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