CYP1A1 and MT1K are congener specific biomarker genes for liver diseases induced by PCBs.

Abstract:

:We have identified two most significant biomarker genes, CYP1A1 (69.81 up-regulation) and MT1K (14.66 up-regulation), showing highest overexpression at p-value <0.005. These were selected out of several hundred genes induced in vitro, using PCB exposed human liver (HepG2) cells. Over expression of the CYP1A1 (cytochrome P450) gene was specific to PCB-77 and MT1K (Metallothionein) to PCB-153. Affymetrix oligonucleotide microarrays (mRNA) were used to screen the entire genome of human liver cells in a time-dependent exposure and were further validated by quantitative real-time RT-PCR.

authors

Dutta SK,Ghosh S,De S,Hoffman EP

doi

10.1016/j.etap.2007.10.018

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

218-21

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(07)00140-8

journal_volume

25

pub_type

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