Abstract:
:We have identified two most significant biomarker genes, CYP1A1 (69.81 up-regulation) and MT1K (14.66 up-regulation), showing highest overexpression at p-value <0.005. These were selected out of several hundred genes induced in vitro, using PCB exposed human liver (HepG2) cells. Over expression of the CYP1A1 (cytochrome P450) gene was specific to PCB-77 and MT1K (Metallothionein) to PCB-153. Affymetrix oligonucleotide microarrays (mRNA) were used to screen the entire genome of human liver cells in a time-dependent exposure and were further validated by quantitative real-time RT-PCR.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Dutta SK,Ghosh S,De S,Hoffman EPdoi
10.1016/j.etap.2007.10.018subject
Has Abstractpub_date
2008-03-01 00:00:00pages
218-21issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(07)00140-8journal_volume
25pub_type
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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journal_title:Environmental toxicology and pharmacology
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