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Protective effect of reduced glutathione on the liver injury induced by acute omethoate poisoning.

Abstract：

:Omethoate is an organophosphate insecticide with high toxicity. The aim of this study was to investigate the protective effect of exogenous reduced glutathione (GSH) on omethoate-induced liver injury. Sprague-Dawley rats were randomly divided into three groups: control, OM (omethoate poisoning), and OM+GSH (omethoate poisoning treated with GSH). The activities of acetylcholinesterase (AChE), aspartate aminotransferase (AST), alanine aminotransferase (ALT) in plasma, free organophosphate (FOP) in the liver were determined, and the histopathological changes in the liver were observed. Furthermore, TNF-α and NO in liver homogenate were assayed. The results showed that AChE activity was significantly inhibited by omethoate, but was not altered by GSH treatment. GSH was able to prevent hepatocellular edema and fatty degeneration, decrease liver FOP, attenuate the increased AST and ALT activity, and decline the increase of TNF-α and NO induced by omethoate. These results indicate GSH can attenuate liver injury, and suggest that GSH may be administered to protect the organ from injury in patients with acute organophosphate poisoning.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Lu L,Wang X,Lang L,Fu F

doi

10.1016/j.etap.2010.08.001

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

279-83

issue

3

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(10)00138-9

journal_volume

30

pub_type

杂志文章

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