Effects of inducers of cytochrome P450s on enrofloxacin N-deethylation in crucian carp Carassius auratus gibelio.

Abstract:

:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (12mg/kg), respectively. First, reversed-phase high-performance liquid chromatography (RP-HPLC) was used to detect the pharmacokinetics of EF with continual blood sampling. In RIF-treated, BNF-treated and control groups, the value of the CmaxCF/CmaxEF ratio was 4.41, 0.81 and 0.95, and the corresponding value of the AUC0-t-CF/AUC0-t-EF ratio was 3.69, 1.84 and 1.76, respectively. In the RIF-treated, BNF-treated and control groups, the MRT values of EF were 26.57, 27.45 and 30.88h, and the corresponding values for CF were 5.79, 35.18 and 38.11h, respectively. Based on these results for crucian carp, the accumulation and elimination of EF and CF in the RIF-treated group were more rapid than in BNF-treated and control groups. Second, liver microsomes were pretreated with the inducer of CYP1A for BNF and that of CYP3A for RIF, and then the enzymatic activities of CYP1A and CYP3A were measured, respectively. The activities of ethoxyresorufin-O-deethylation (EROD) and erythromycin-N-demethylation (ERND) increased significantly (P<0.05) for CYP1A and CYP3A, respectively. However, in further experiments on the formation of CF, the level of EF N-deethylation was significantly induced by RIF and inhibited by ketoconazole (KTZ) for CYP3A but had no influence for CYP1A, BNF and berberine chloride (BER). We concluded that CYP3A might be responsible for the N-deethylation of EF and because of this activity, could also serve as a toxicity biomarker in crucian carp.

authors

Fu G,Zhou C,Wang Y,Fang W,Zhou J,Zhao S,Ma L

doi

10.1016/j.etap.2016.07.015

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

188-193

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(16)30193-4

journal_volume

46

pub_type

杂志文章
  • Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.

    abstract::This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.10.019

    authors: Jiang P,Sheng YC,Chen YH,Ji LL,Wang ZT

    更新日期:2014-11-01 00:00:00

  • Cytotoxicity of HC Orange NO. 1 to L929 fibroblast cells.

    abstract::HC Orange No. 1 (HCO1, 2-nitro-4'-hydroxydiphenylamine) (CAS No. 54381-08-7) is used as a colorant in commercial hair dyes. The cytotoxicity of HCO1 to L929 mouse connective tissue fibroblast cells was determined by use of a battery of endpoints that included electron transport activity determined by the MTT assay and...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.06.002

    authors: Liu H,Chen J,Jiang J,Giesy JP,Yu H,Wang X

    更新日期:2008-11-01 00:00:00

  • Potential role of vitamins in chromium induced spermatogenesis in Swiss mice.

    abstract::Chromium (Cr) (VI) compounds are known carcinogens and mutagens. The mechanism of carcinogenicity and mutagenicity caused by chromium(VI) compounds remained unclear for several years. However, in the recent past chromium-induced carcinogenicity and/or mutagenicity was known to happen due to the generation of reactive ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2003.08.010

    authors: Acharya UR,Mishra M,Mishra I,Tripathy RR

    更新日期:2004-01-01 00:00:00

  • Genistein ameliorated endothelial nitric oxidase synthase uncoupling by stimulating sirtuin-1 pathway in ox-LDL-injured HUVECs.

    abstract::Endothelial nitric oxidase synthase (eNOS) uncoupling plays a causal role in endothelial dysfunction in atherosclerosis. Genistein consumption has been associated with the prevention of atherosclerosis. However, the effect of genistein on eNOS uncoupling has not been reported. A model of oxidized low-density lipoprote...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2016.01.011

    authors: Zhang HP,Zhao JH,Yu HX,Guo DX

    更新日期:2016-03-01 00:00:00

  • Effects of prednisolone on behavior and hypothalamic-pituitary-interrenal axis activity in zebrafish.

    abstract::Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103325

    authors: Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

    更新日期:2020-04-01 00:00:00

  • Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects.

    abstract::We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were t...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(00)00060-0

    authors: Giménez-Llort L,Ahlbom E,Daré E,Vahter M,Ögren S,Ceccatelli S

    更新日期:2001-01-01 00:00:00

  • Copper effect on the biomarker state of the Mizuhopecten yessoensis tissues in the prespawning period.

    abstract::The aim of this study was to investigate the sensitivity of the marine scallop Mizuhopecten yessoensis to different copper concentrations (10 and 30 μgl-1) in the prespawning period. Reaction of the scallop to this effect was evaluated by a set of biomarkers, including general metabolism enzymes (acid and alkaline pho...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2019.04.010

    authors: Istomina A,Chelomin V,Kukla S,Zvyagintsev A,Karpenko A,Slinko E,Dovzhenko N,Slobodskova V,Kolosova L

    更新日期:2019-08-01 00:00:00

  • A new index to assess chemicals increasing the greenhouse effect based on their toxicity to algae.

    abstract::CO2, as the typical greenhouse gas causing the greenhouse effect, is a major global environmental problem and has attracted increasing attention from governments. Using algae to eliminate CO2, which has been proposed as an effective way to reduce the greenhouse effect in the past decades, can be disturbed by a growing...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.08.034

    authors: Wang T,Zhang X,Tian D,Gao Y,Lin Z,Liu Y,Kong L

    更新日期:2015-11-01 00:00:00

  • Bisphenol A affects cell viability involved in autophagy and apoptosis in goat testis sertoli cell.

    abstract::Bisphenol A (BPA) is shown to be the endocrine disruptor that induces reproductive dysfunction in male animals. In this study, we aim to probe the effects of BPA exposure on induction of autophagy in goat Sertoli Cells (gSCs), as well as the relationship between autophagy and apoptosis. Results indicated that exposure...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.07.014

    authors: Zhang Y,Han L,Yang H,Pang J,Li P,Zhang G,Li F,Wang F

    更新日期:2017-10-01 00:00:00

  • Altered expression profiles of microRNAs upon arsenic exposure of human umbilical vein endothelial cells.

    abstract::Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.05.003

    authors: Li X,Shi Y,Wei Y,Ma X,Li Y,Li R

    更新日期:2012-09-01 00:00:00

  • The teratogenic effects of polychlorinated naphthalenes (PCNs) on early development of the zebrafish (Danio rerio).

    abstract::The present study examines the effects of PCN congeners (PCN50 and PCN66) on zebrafish embryos. The embryos were exposed to different concentrations (20, 30 and 50μg/l) of the respective congeners by dissolving 0.08% acetone. The following endpoints were investigated (mortality, hatching rate, abnormalities and heart ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2007.09.001

    authors: Sişman T,Geyikoğlu F

    更新日期:2008-01-01 00:00:00

  • Deferasirox-induced cytogenetic responses.

    abstract::Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.02.001

    authors: Arslan M,Ila HB

    更新日期:2015-03-01 00:00:00

  • Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking.

    abstract::The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVI...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2020.103411

    authors: Engin AB,Engin ED,Engin A

    更新日期:2020-08-01 00:00:00

  • Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages.

    abstract::To investigate the regulated role of IL-1β in initiating and maintaining inflammation, PMA-differentiated THP-1 macrophages were exposed to two micro-sized crystalline silica particles (Si3-5μm and Si1μm) from 3h to 24h, respectively. Cytotoxicity and inflammatory cytokines (IL-1β, TNF-α and IL-6) expressions measured...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.12.017

    authors: Zhou T,Cui X,Zhou Y,Guo J,Rong Y,Chen W

    更新日期:2015-01-01 00:00:00

  • Association of arsenic exposure with smoking, alcohol, and caffeine consumption: data from NHANES 2005-2010.

    abstract::Association of arsenic exposure with smoking, alcohol, and caffeine consumption was investigated. Data from National Health and Nutrition Examination Survey for the years 2005-2010 were used for this investigation. Urinary levels of total arsenic (UAS) and dimethylarsonic acid (UDMA) were evaluated for children aged 6...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.01.011

    authors: Jain RB

    更新日期:2015-03-01 00:00:00

  • Enhanced contractility of vascular smooth muscle after brief exposure to arsenate.

    abstract::Epidemiological studies indicate that arsenic exposure induces hypertension. We hypothesized that arsenate exposure modulates the contractility of vascular smooth muscle through the stress response. Intraperitoneal injection of sodium arsenate (15mg/kg) 16h before increased not only the blood pressure of rats but also...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.08.002

    authors: Park TG,Seong Y,Suk K,Ha JH,Kim I

    更新日期:2005-02-01 00:00:00

  • Chemical change of chlorinated bisphenol A by ultraviolet irradiation and cytotoxicity of their products on Jurkat cells.

    abstract::Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2005.09.005

    authors: Mutou Y,Ibuki Y,Terao Y,Kojima S,Goto R

    更新日期:2006-05-01 00:00:00

  • Selective induction of the CYP3A family by endosulfan and DNA-adduct formation in different hepatic and hepatoma cells.

    abstract::Endosulfan, a chlorinated cyclodiene insecticide, is known to cause a significant enhancement of altered hepatic foci in rats and to be a potent inhibitor of gap-junctional intercellular communication in vitro. Both of these features are common to many tumor promoters. However, long-term studies in rodents provide no ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/1382-6689(96)00018-X

    authors: Dubois M,Pfohl-Leszkowicz A,De Waziers I,Kremers P

    更新日期:1996-07-15 00:00:00

  • Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats.

    abstract::The protective effects of lobenzarit disodium against the toxicity of allyl alcohol were investigated in vitro using isolated rat hepatocytes and in vivo using mice. In mice, at i.p doses of 25, 50 and 100 mg/kg lobenzarit significantly decreased the activity of alanine amino transferase (ALT) in serum and the concent...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)00149-x

    authors: Remirez D,Commandeur JN,Groot E,Gonzalez R,Rodriguez S,Ancheta O,Rojas E,Ramos ME,Vermeulen NP

    更新日期:1997-06-06 00:00:00

  • Effects of cigarette smoke on Holter ECG recordings in patients with arterial hypertension. Part 2: Parameters of heart rate turbulence.

    abstract:UNLABELLED:The studies aimed at evaluation of cigarette smoke effect on heart rate turbulence (HRT) in patients with arterial hypertension (AH). 223 consecutive individuals were qualified to the studies. The following groups of patients not suffering from other disease which may affect HRT were distinguished: 1--patien...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.01.022

    authors: Gać P,Sobieszczańska M

    更新日期:2014-03-01 00:00:00

  • Quercetin abrogates bisphenol A induced altered neurobehavioral response and oxidative stress in zebrafish by modulating brain antioxidant defence system.

    abstract::Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103483

    authors: Sahoo PK,Pradhan LK,Aparna S,Agarwal K,Banerjee A,Das SK

    更新日期:2020-11-01 00:00:00

  • Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.

    abstract::Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological eff...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2018.05.022

    authors: Wu H,Zhong M,Lu Z,Shan X,Li F,Ji C,Cong M

    更新日期:2018-07-01 00:00:00

  • Neurotoxic effects of acute and subacute formaldehyde exposures in mice.

    abstract::In this study, the effects of acute and subacute formaldehyde (FA) exposures on spontaneous locomotor activity (SLMA), wet dog shake (WDS) behavior and pentylenetetrazole (PTZ) induced seizures were evaluated in Balb/C mice. SLMA was concentration dependently reduced after acute FA exposures at 1.8, 3.2, 4.5, 6.4, 9.7...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(01)00109-0

    authors: Usanmaz SE,Akarsu ES,Vural N

    更新日期:2002-03-01 00:00:00

  • Association of inflammatory response and oxidative injury in the pathogenesis of liver steatosis and insulin resistance following subchronic exposure to malathion in rats.

    abstract::Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.08.007

    authors: Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

    更新日期:2014-09-01 00:00:00

  • Arsenic may be involved in fluoride-induced bone toxicity through PTH/PKA/AP1 signaling pathway.

    abstract::Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.11.027

    authors: Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

    更新日期:2014-01-01 00:00:00

  • Polyphenolic fraction of Pilea microphylla (L.) protects Chinese hamster lung fibroblasts against γ-radiation-induced cytotoxicity and genotoxicity.

    abstract::Present study was designed to compare cytoprotective and antigenotoxic activity of the polyphenolic fraction of Pilea microphylla (PM1) with that of its active polyphenolic constituents against γ-radiation in V79 cells. PM1 was standardized with respect to the polyphenols present by RP-HPLC. It was evaluated for its f...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.09.007

    authors: Paul P,Bansal P,Nayak PG,Pannakal ST,Priyadarsini KI,Unnikrishnan MK

    更新日期:2012-01-01 00:00:00

  • Nonylphenol-induced hyperadrenalism can be reversed/alleviated by inhibiting of 11-β hydroxysteroid dehydrogenase type 1.

    abstract::We previously observed that nonylphenol (NP) exposure during development resulted in increases in body weight and hyperadrenalism in adult male offspring. The mechanism of hyperadrenalism includes the primary activation of the adrenal gland and the conversion of inactive glucocorticoids to active glucocorticoids by 11...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2016.03.019

    authors: Chang LL,Wun WS,Wang PS

    更新日期:2016-06-01 00:00:00

  • Blood selenium concentration in a selected population of children inhabiting industrial regions in Upper Silesia (Poland).

    abstract:PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.06.005

    authors: Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

    更新日期:2012-09-01 00:00:00

  • Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: Protective effect of bacoside A.

    abstract::Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2005.03.006

    authors: Anbarasi K,Sabitha KE,Devi CS

    更新日期:2005-09-01 00:00:00

  • Age-related susceptibility to immunotoxicants: animal data and human parallels.

    abstract::There are numerous examples, of both the identical and different effects of animals exposure to toxic agents, which can be compared in both, exposed prenatal/neonatal animals and exposed adults. In some instances, although the chemical and its metabolites are stored for long periods in adipose tissue, adult exposure (...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)10030-8

    authors: Barnett JB

    更新日期:1997-12-01 00:00:00