Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.

Abstract:

:The purpose of this study was to determine the interethnic differences of four CYP1A2 drug metabolizing enzyme variants. A total of 404 Roma and 396 Hungarian healthy subjects were genotyped for -163C>A, -729C>T, -2467delT and -3860G>A variants of CYP1A2 by RT-PCR and PCR-RFLP technique. The -3860A and -729T allele were not detectable in Roma samples, while in Hungarian samples were present with 2.02% and 0.25% prevalence, respectively. There was a 1.5-fold difference in presence of homozygous -163AA genotype between Hungarian and Roma samples (49.5% vs. 31.9%, p<0.001). The -163A allele frequency was 68.6% in Hungarians and 56.9% in Romas (p=0.025). The -2467delT allele frequency was 6.81% in Roma group and 5.81% in Hungarians. The most frequent allelic constellation was -3860G/-2467T/-729C/-163A in both populations. In conclusion, Hungarians have markedly elevated chance for rapid metabolism of CYP1A2 substrates, intensified procarcinogen activation and increased risk for cancers.

authors

Szalai R,Magyari L,Matyas P,Duga B,Banfai Z,Szabo A,Kovesdi E,Melegh B

doi

10.1016/j.etap.2014.09.012

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

814-20

issue

3

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00220-8

journal_volume

38

pub_type

杂志文章
  • Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects.

    abstract::We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were t...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(00)00060-0

    authors: Giménez-Llort L,Ahlbom E,Daré E,Vahter M,Ögren S,Ceccatelli S

    更新日期:2001-01-01 00:00:00

  • Quercetin abrogates bisphenol A induced altered neurobehavioral response and oxidative stress in zebrafish by modulating brain antioxidant defence system.

    abstract::Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103483

    authors: Sahoo PK,Pradhan LK,Aparna S,Agarwal K,Banerjee A,Das SK

    更新日期:2020-11-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes.

    abstract::Inhibition of apoptosis of preneoplastic cells is thought to represent a major mechanism of action of tumor promoters. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent promoter of liver carcinogenesis in rodents, suppressed apoptosis in rat hepatocytes pretreated in vitro with an apoptogenic dose of UV ligh...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(98)00040-4

    authors: Wörner W,Schrenk D

    更新日期:1998-12-01 00:00:00

  • Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers.

    abstract::We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.etap.2014.01.024

    authors: Kasperczyk S,Dobrakowski M,Kasperczyk A,Machnik G,Birkner E

    更新日期:2014-03-01 00:00:00

  • Genotoxicity of glyphosate assessed by the comet assay and cytogenetic tests.

    abstract::It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42±1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p<0.01) with glyphosate at a range concen...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2009.02.001

    authors: Mañas F,Peralta L,Raviolo J,Ovando HG,Weyers A,Ugnia L,Cid MG,Larripa I,Gorla N

    更新日期:2009-07-01 00:00:00

  • Environmental epigenomics: Current approaches to assess epigenetic effects of endocrine disrupting compounds (EDC's) on human health.

    abstract::Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemi...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2017.02.004

    authors: Tapia-Orozco N,Santiago-Toledo G,Barrón V,Espinosa-García AM,García-García JA,García-Arrazola R

    更新日期:2017-04-01 00:00:00

  • Nicotine withdrawal alleviates acetic acid-induced gastric injury in rats.

    abstract::Epidemiological and experimental studies have demonstrated that cigarette smoking intensifies gastric ulceration. Although nicotine can act as an anxiolytic and antidepressant, its withdrawal may also lead to increased anxiety and depression. In order to associate the toxic actions of nicotine on gastric mucosa with a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.10.006

    authors: Deniz M,Sahin HH,Tekin S,Yeşiller M,Ağaoğlu B,Cetinel S,Yeğen BÇ

    更新日期:2009-03-01 00:00:00

  • Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.

    abstract::This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of Dip with rat liver microsomes yielded four meta...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.08.019

    authors: Guo W,Shi X,Wang W,Zhang W,Li J

    更新日期:2014-11-01 00:00:00

  • Aluminum-induced suppression of testosterone through nitric oxide production in male mice.

    abstract::Excessive nitric oxide (NO) production in mice serum and testis due to aluminum (Al) exposure has been shown in previous studies. The aim of this study was to further investigate the role of NO on aluminum-suppressed testosterone level in male CD-1 mice. Each animal in six groups, was given intraperitoneal injections ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.02.009

    authors: Guo CH,Lin CY,Yeh MS,Hsu GS

    更新日期:2005-01-01 00:00:00

  • Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells.

    abstract::In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pr...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.02.016

    authors: Hou H,Zhou R,Li A,Li C,Li Q,Liu J,Jiang B

    更新日期:2014-03-01 00:00:00

  • Concentrating nanoparticles in environmental monitoring.

    abstract::There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.06.015

    authors: Cheong BH,Muradoglu M,Liew OW,Ng TW

    更新日期:2015-07-01 00:00:00

  • Effect of low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats.

    abstract::The objective of this study was to compare effects of Western diet (WD) with low carbohydrate high protein (LCHP) diet on lipid metabolism, liver and kidney function in rats. Eighteen rats were randomly assigned to three experimental groups and fed for the next 2 months. The experimental diets were: Control (7% of soy...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.01.008

    authors: Kostogrys RB,Franczyk-Żarów M,Maślak E,Topolska K

    更新日期:2015-03-01 00:00:00

  • Determination of fluoroquinolones in chicken feces - a new liquid-liquid extraction method combined with LC-MS/MS.

    abstract::The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necessary to determine the antibiotic concentration in feces. Ther...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.09.011

    authors: Janusch F,Scherz G,Mohring SA,Hamscher G

    更新日期:2014-11-01 00:00:00

  • Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.

    abstract::Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.02.022

    authors: Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

    更新日期:2017-04-01 00:00:00

  • Effects of prednisolone on behavior and hypothalamic-pituitary-interrenal axis activity in zebrafish.

    abstract::Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103325

    authors: Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

    更新日期:2020-04-01 00:00:00

  • Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro.

    abstract::Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric c...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.01.001

    authors: Pohanka M

    更新日期:2014-01-01 00:00:00

  • Effects of atrazine and chlorpyrifos on activity and transcription of glutathione S-transferase in common carp (Cyprinus carpio L.).

    abstract::Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.12.014

    authors: Xing H,Wang X,Sun G,Gao X,Xu S,Wang X

    更新日期:2012-03-01 00:00:00

  • The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.

    abstract:OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.02.006

    authors: Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

    更新日期:2012-07-01 00:00:00

  • Differential tissue regulation of peroxisome proliferator-activated receptor α (PPARα) and cannabinoid receptor 1 (CB1) gene transcription pathways by diethylene glycol dibenzoate (DEGB): preliminary observations in a seabream (Sparus aurata) in vivo mode

    abstract::Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.08.015

    authors: Cocci P,Mozzicafreddo M,Angeletti M,Mosconi G,Palermo FA

    更新日期:2017-10-01 00:00:00

  • Bisphenol A and its analogs: Do their metabolites have endocrine activity?

    abstract::Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2016.09.014

    authors: Gramec Skledar D,Peterlin Mašič L

    更新日期:2016-10-01 00:00:00

  • GS-2, a pyrazolo[1,5-a]indole derivative with inhibitory activity of topoisomerases, exerts its potent cytotoxic activity by ROS generation.

    abstract::Pyrazolo[1,5-a]indole derivatives, a new type of topoisomerase (topo) inhibitor, demonstrate a broad spectrum of antitumor activities. However, the mechanism underlying the induced cytotoxicity remains unclear. In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast can...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.09.019

    authors: Ji YY,Zhu YM,Wang JW

    更新日期:2013-11-01 00:00:00

  • Comparative cardioprotective effects and mechanisms of vitamin E and lisinopril against ischemic reperfusion induced cardiac toxicity.

    abstract::The present study was undertaken to scientifically evaluate, validate and compare the cardioprotective effects of lisinopril (Lsp), an angiotensin converting enzyme (ACE) inhibitor and vitamin E (Vit E), an antioxidant in the setting of ischemia and reperfusion (I-R) injury. An open chest left anterior descending coro...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2012.12.003

    authors: Mohanty IR,Arya DS,Dinda A,Gupta SK

    更新日期:2013-03-01 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes an Ah receptor-dependent and ARNT-independent increase in membrane levels and activity of p60(Src).

    abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known to affect various cellular activities including growth factor signal transduction, hormone responses, and cell differentiation. The purpose of this study was to examine more closely the very early effects of TCDD on protein tyrosine kinase activity, specifically p60(...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)00016-1

    authors: Blankenship A,Matsumura F

    更新日期:1997-07-01 00:00:00

  • Diaryl sulfide analogs of combretastatin A-4: Toxicogenetic, immunomodulatory and apoptotic evaluations and prospects for use as a new chemotherapeutic drug.

    abstract::Combretastatin A-4 exhibits efficient anti-cancer potential in human tumors, including multidrug-resistant tumors. We evaluated the mutagenic, apoptotic and immunomodulatory potential of two diaryl sulfide analogs of combretastatin A-4, 1,2,3-trimethoxy-5-([4-methoxy-3-nitrophenyl]thio)benzene (analog 1) and 1,2,3-tri...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.08.028

    authors: Carvalho PC,Santos EA,Schneider BU,Matuo R,Pesarini JR,Cunha-Laura AL,Monreal AC,Lima DP,Antoniolli AC,Oliveira RJ

    更新日期:2015-11-01 00:00:00

  • Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway.

    abstract::Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.11.008

    authors: Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

    更新日期:2009-03-01 00:00:00

  • Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

    abstract::Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.11.018

    authors: Chu H,Tang Q,Huang H,Hao W,Wei X

    更新日期:2016-01-01 00:00:00

  • A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

    abstract::The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.12.025

    authors: Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

    更新日期:2018-03-01 00:00:00

  • Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.

    abstract::Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, at...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103350

    authors: Wu Z,Bai L,Tu R,Zhang L,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

    更新日期:2020-05-01 00:00:00

  • Food flavor cinnamaldehyde-induced biochemical and histological changes in the kidney of male albino wistar rat.

    abstract::Rats were given food flavor cinnamaldehyde (CNMA) orally by gavage at the dose of 2.14, 6.96, 22.62 and 73.5mg/kg body weight/day for 10, 30 and 90 days. Only the group of rats treated with CNMA at the dose 73.5mg/kg body weight/day for 90 days showed histological changes in the kidney followed by increased activities...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.02.002

    authors: Gowder SJ,Devaraj H

    更新日期:2008-07-01 00:00:00

  • 4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.

    abstract::4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2018.07.010

    authors: Huang S,Cao S,Zhou T,Kong L,Liang G

    更新日期:2018-09-01 00:00:00