当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

Abstract：

:Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear factor-kappaB (NF-κB) signal transduction pathways in lipopolysaccharide (LPS) -stimulated RAW264.7 cells. GSPs extract has been found to suppress the mRNA expression of pro-inflammatory cytokines like tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and inflammatory molecule of cyclooxygenase-2 (COX-2) while mRNA level of IL-10 was greatly promoted. Furthermore, GSPs extract inhibited the expression of phosphorylated ERK, JNK and P38, as well as phosphorylated IKKα/β and NF-κB p65 subunit. In conclusion, our results show that GSPs extract showed its anti-inflammatory and immunomodulatory properties by suppressing the activation of MAP kinases and NF-κB signal transduction pathways.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Chu H,Tang Q,Huang H,Hao W,Wei X

doi

10.1016/j.etap.2015.11.018

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

159-66

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(15)30135-6

journal_volume

41

pub_type

杂志文章

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

    abstract：:A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathione S-transferase enzymes. The main enzymes involved both for rats and ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(02)00019-4

    authors： Hissink EM,Bogaards JJ,Freidig AP,Commandeur JN,Vermeulen NP,van Bladeren PJ

    更新日期：2002-07-01 00:00:00

  • A focus on the human lens in vitro.

    abstract：:The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.07.012

    authors： Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期：2006-02-01 00:00:00

  • The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.

    abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.02.006

    authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

    更新日期：2012-07-01 00:00:00

  • Alternative electron acceptors: Proposed mechanism of paraquat mitochondrial toxicity.

    abstract：:Paraquat (PQ) is a relatively safe and effective herbicide used all over the world. PQ is very toxic to all living organisms; and many cases of acute poisoning and death have been reported over the past decade. The main suggested potential mechanism for PQ toxicity is the production of superoxide radicals from the met...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.02.009

    authors： Mohammadi-Bardbori A,Ghazi-Khansari M

    更新日期：2008-07-01 00:00:00

  • Arsenic may be involved in fluoride-induced bone toxicity through PTH/PKA/AP1 signaling pathway.

    abstract：:Chronic exposure to combined fluoride and arsenic continues to be a major public health problem worldwide, affecting thousands of people. In recent years, more and more researchers began to focus on the interaction between the fluorine and the arsenic. In this study, the selected investigation site was located in Chin...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.11.027

    authors： Zeng QB,Xu YY,Yu X,Yang J,Hong F,Zhang AH

    更新日期：2014-01-01 00:00:00

  • A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

    abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.025

    authors： Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

    更新日期：2018-03-01 00:00:00

  • The effect of phytosterol protects rats against 4-nitrophenol-induced liver damage.

    abstract：:We investigated the effect of phytosterol (PS) in regard to liver damage induced by 4-nitrophenol (PNP). Twenty rats were randomly divided into four groups (Control, PS, PNP, and PNP+PS). The PS and PNP+PS groups were pretreated with PS for one week. The PNP and PNP+PS groups were injected subcutaneously with PNP for ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.12.011

    authors： Chen J,Song M,Li Y,Zhang Y,Taya K,Li C

    更新日期：2016-01-01 00:00:00

  • Function of respiratory system evaluated using selected spirometry parameters in persons occupationally exposed to lead without evident health problems.

    abstract：UNLABELLED:This study aimed at evaluation of selected spirometric parameters in persons occupationally exposed to lead without evident health problems. The studies were conducted on 69 men occupationally exposed to lead. Occupational exposure to lead was characterized by estimation of blood lead concentration (Pb-B) an...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.03.009

    authors： Jurdziak M,Gać P,Martynowicz H,Poręba R

    更新日期：2015-05-01 00:00:00

  • Deoxynivalenol induces apoptosis in PC12 cells via the mitochondrial pathway.

    abstract：:Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.03.016

    authors： Wang X,Xu W,Fan M,Meng T,Chen X,Jiang Y,Zhu D,Hu W,Gong J,Feng S,Wu J,Li Y

    更新日期：2016-04-01 00:00:00

  • Neurotoxic effects of acute and subacute formaldehyde exposures in mice.

    abstract：:In this study, the effects of acute and subacute formaldehyde (FA) exposures on spontaneous locomotor activity (SLMA), wet dog shake (WDS) behavior and pentylenetetrazole (PTZ) induced seizures were evaluated in Balb/C mice. SLMA was concentration dependently reduced after acute FA exposures at 1.8, 3.2, 4.5, 6.4, 9.7...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(01)00109-0

    authors： Usanmaz SE,Akarsu ES,Vural N

    更新日期：2002-03-01 00:00:00

  • 18β-Glycyrrhetinic acid mitigates radiation-induced skin damage via NADPH oxidase/ROS/p38MAPK and NF-κB pathways.

    abstract：:Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.04.012

    authors： Su L,Wang Z,Huang F,Lan R,Chen X,Han D,Zhang L,Zhang W,Hong J

    更新日期：2018-06-01 00:00:00

  • A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry.

    abstract：:Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were random...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.07.018

    authors： Xing W,Gu L,Zhang X,Xu J,Lu H

    更新日期：2016-09-01 00:00:00

  • Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers.

    abstract：:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.etap.2014.01.024

    authors： Kasperczyk S,Dobrakowski M,Kasperczyk A,Machnik G,Birkner E

    更新日期：2014-03-01 00:00:00

  • Cell metabolic changes of porphyrins and superoxide anions by anthracene and benzo(a)pyrene.

    abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.05.002

    authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

    更新日期：2008-09-01 00:00:00

  • Species-specific models in toxicology: in vitro epithelial barriers.

    abstract：:Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an I...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2019.103203

    authors： Bertero A,Augustyniak J,Buzanska L,Caloni F

    更新日期：2019-08-01 00:00:00

  • Differential gene expression profiles of human leukemia cell lines exposed to benzene and its metabolites.

    abstract：:Benzene is a well-known environmental pollutant that can induce hematotoxicity, aplastic anemia, acute myelogenous leukemia, and lymphoma. Benzene toxicity is likely mediated through metabolites induced by means of multiple pathways. Although benzene metabolites are known to induce oxidative stress and disrupt the cel...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.06.001

    authors： Sarma SN,Kim YJ,Ryu JC

    更新日期：2011-09-01 00:00:00

  • Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.

    abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.022

    authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

    更新日期：2017-04-01 00:00:00

  • Low-level styrene exposure and color vision in Swedish styrene workers.

    abstract：:Styrene exposure and color vision for 108 workers (21-65 years) was studied at Swedish reinforced plastic plants. Acute exposure was measured at work. Data on past exposures and personal background data were collected by questionnaire. Current exposure varied between 0.3 and 96mg/m(3). Cumulative past exposures varied...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.12.057

    authors： Iregren A,Johnson AC,Nylén P

    更新日期：2005-05-01 00:00:00

  • Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts.

    abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.11.023

    authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

    更新日期：2016-03-01 00:00:00

  • The role of 3-methylsulfonyl-2,2',4',5,5'-pentachlorobiphenyl, a metabolite of 2,2',4,5,5'-pentachlorobiphenyl, in the induction of hepatic microsomal drug-metabolizing enzymes by 2,2',4,5,5'-pentachlorobiphenyl in rats.

    abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(99)00028-9

    authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

    更新日期：1999-12-01 00:00:00

  • Use of acetylcholinesterase, glutathione S-transferase and cytochrome P450 1A1 in Capoeta umbla as biomarkers for monitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey).

    abstract：:Uzuncayir Dam Lake is one of the most important water bodies in Tunceli. It is polluted by domestic wastewaters together with natural contamination and pesticides, which have had cumulatively negative effects. This study analyzes the effects of pollution by using the fish species, Capoeta umbla as a sentinel species, ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.04.001

    authors： Yildirim NC,Yildirim N,Danabas D,Danabas S

    更新日期：2014-05-01 00:00:00

  • Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells.

    abstract：:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investig...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.06.006

    authors： Niu Z,Zhang W,Gu X,Zhang X,Qi Y,Zhang Y

    更新日期：2016-07-01 00:00:00

  • Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

    abstract：:Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.12.016

    authors： Wang W,Chen QF,Li QB,Wu YB,Chen K,Chen B,Wen JM

    更新日期：2014-03-01 00:00:00

  • Switch regulation of interleukin-1 beta in downstream of inflammatory cytokines induced by two micro-sized silica particles on differentiated THP-1 macrophages.

    abstract：:To investigate the regulated role of IL-1β in initiating and maintaining inflammation, PMA-differentiated THP-1 macrophages were exposed to two micro-sized crystalline silica particles (Si3-5μm and Si1μm) from 3h to 24h, respectively. Cytotoxicity and inflammatory cytokines (IL-1β, TNF-α and IL-6) expressions measured...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.12.017

    authors： Zhou T,Cui X,Zhou Y,Guo J,Rong Y,Chen W

    更新日期：2015-01-01 00:00:00

  • Evaluation of the acute toxicity of perfluorinated carboxylic acids using eukaryotic cell lines, bacteria and enzymatic assays.

    abstract：:The acute biological activity of a homologous series of perfluorinated carboxylic acids - perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) - was studied. To analyze the potential risk of the perfluorinated ac...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2006.11.002

    authors： Mulkiewicz E,Jastorff B,Składanowski AC,Kleszczyński K,Stepnowski P

    更新日期：2007-05-01 00:00:00

  • Distribution and pharmacokinetics of alkylphenolic compounds in primary mouse hepatocyte cultures.

    abstract：:In order to allow an interpretation of in vitro results on the estrogenic potency of 4-nonylphenol (NP) and 4-octylphenol (OP), their distribution and pharmacokinetics were investigated in primary mouse hepatocyte cultures. 10(-5) M NP and 10(-6)M OP were added to the hepatocyte cultures and incubated up to 48 h. The ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(98)00018-0

    authors： Müller S,Schmid P,Schlatter C

    更新日期：1998-08-04 00:00:00

  • GS-2, a pyrazolo[1,5-a]indole derivative with inhibitory activity of topoisomerases, exerts its potent cytotoxic activity by ROS generation.

    abstract：:Pyrazolo[1,5-a]indole derivatives, a new type of topoisomerase (topo) inhibitor, demonstrate a broad spectrum of antitumor activities. However, the mechanism underlying the induced cytotoxicity remains unclear. In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast can...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.09.019

    authors： Ji YY,Zhu YM,Wang JW

    更新日期：2013-11-01 00:00:00

  • Latent role of in vitro Pb exposure in blocking Aβ clearance and triggering epigenetic modifications.

    abstract：:Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.12.015

    authors： Wang Y,Hu Y,Wu Z,Su Y,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

    更新日期：2019-02-01 00:00:00

  • Polyphenolic fraction of Pilea microphylla (L.) protects Chinese hamster lung fibroblasts against γ-radiation-induced cytotoxicity and genotoxicity.

    abstract：:Present study was designed to compare cytoprotective and antigenotoxic activity of the polyphenolic fraction of Pilea microphylla (PM1) with that of its active polyphenolic constituents against γ-radiation in V79 cells. PM1 was standardized with respect to the polyphenols present by RP-HPLC. It was evaluated for its f...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.09.007

    authors： Paul P,Bansal P,Nayak PG,Pannakal ST,Priyadarsini KI,Unnikrishnan MK

    更新日期：2012-01-01 00:00:00

  • Circulating miRNA-126, -145 and -155 levels in Mexican women exposed to inorganic arsenic via drinking water.

    abstract：:The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were anal...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.02.004

    authors： Ruíz-Vera T,Ochoa-Martínez ÁC,Zarazúa S,Carrizales-Yáñez L,Pérez-Maldonado IN

    更新日期：2019-04-01 00:00:00