Abstract：
:Exposure to lead (Pb) or polychlorinated biphenyls (PCBs) during early development has been associated with deficits in cognitive function in children (Pediatrics 87 (1991) 219; N. Engl. J. Med. 335 (1996) 783). These effects persist in the child long after exposure has ceased and body burdens have diminished. Despite intensive research, no consensus on the mechanisms of neurotoxicity of these chemicals has resulted. As the primary neurotoxic action of these agents is to impair cognitive ability, a number of laboratories have examined and reported on the detrimental the effects of Pb or PCBs on hippocampal synaptic transmission and long-term potentiation (LTP) in animals exposed during the perinatal period. Use-dependent synaptic plasticity, of which hippocampal LTP is the primary model system, is a fundamental property of neuronal function. In forebrain structures such as amygdala and hippocampus, LTP and related processes are purported to represent a physiological substrate for memory. During brain ontogeny, this type of plasticity guides the establishment and maintenance of synaptic connections in cortical structures based on sensory input. We postulate that the actions of PCBs and Pb in the developing nervous system perturb activity-dependent plasticity and promote organizational changes in brain. Aberrant connectivity derived from perturbations in activity-dependent plasticity during development may manifest as impaired LTP and cognitive ability in the adult organism.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Gilbert ME,Lasley SMdoi
10.1016/s1382-6689(02)00029-7subject
Has Abstractpub_date
2002-09-01 00:00:00pages
105-17issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(02)00029-7journal_volume
12pub_type
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(02)00011-x
更新日期：2002-08-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10042-4
更新日期：1997-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.10.016
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
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更新日期：2016-12-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2017-06-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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更新日期：2005-01-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(99)00006-x
更新日期：1999-04-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2015-11-01 00:00:00
abstract：:There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorat...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.03.007
更新日期：2009-07-01 00:00:00
