Abstract:
:A green fluorescent protein (GFP)-reporter vector regulated by an estrogen response element (ERE) was constructed and transfected into human breast carcinoma MCF7 cells. Stable transfectants were selected and their GFP fluorescence intensity was measured using a quantitative fluorescent imaging system. 17β-estradiol (E(2)) and bisphenol A (BPA) induced a dose-dependent increase in GFP intensity in the cells, reaching maximum response at 5×10(-10) and 10(-5) M, respectively. Using this GFP expression system, we examined the estrogenicity of mono-, di-, tri-, and tetra-chlorinated BPAs, which were detected in wastewater from waste-paper recycling plants using sodium hypochlorite as a bleaching agent. 3-ClBPA and 3,3'-diClBPA showed similar estrogenicities, effective at lower concentrations than parent BPA. On the other hand, the maximum activities of BPA and 3,3',5-triClBPA, whose EC(50) were similar, were higher than other chlorinated BPAs. This is the first demonstration of the estrogenicity of chlorinated BPAs. Since polychlorinated BPAs were not easily biodegraded, chlorinated BPAs might be more severe endocrine disruptors than BPA.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Kuruto-Niwa R,Terao Y,Nozawa Rdoi
10.1016/s1382-6689(02)00011-xsubject
Has Abstractpub_date
2002-08-01 00:00:00pages
27-35issue
1eissn
1382-6689issn
1872-7077pii
S1382-6689(02)00011-Xjournal_volume
12pub_type
杂志文章abstract::The hypothesis that temperature variation is able to modify the chronic toxicity of the antibiotic florfenicol (FLO) to Daphnia magna was tested in the present study. Twenty-one day laboratory bioassays were carried out at 20 and 25 °C. FLO concentrations and its potential decay during the assays were checked by spect...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.09.001
更新日期:2013-11-01 00:00:00
abstract::DNA damage caused by environmental agents often lead to many chronic diseases, including cancer. The present study aimed to understand the relative toxicity possessed by Bisphenol A (BPA) and Bisphenol S (BPS) on human bronchial epithelial cells (BEAS-2B). The cells were exposed to either BPA or BPS and evaluated for ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2018.04.009
更新日期:2018-06-01 00:00:00
abstract::A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(97)10007-2
更新日期:1998-01-01 00:00:00
abstract::The wide range of potential health beneficial effects of isoflavones, including a chemoprentive action, have prompted us to study the potential benefits of genistein and daidzein in an experimental model of environmental pollution impact on lung tissue. A diesel engine placed was used to generate reproducible emission...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(02)00066-2
更新日期:2002-11-01 00:00:00
abstract::Chlorinated derivatives of bisphenol A (ClBPAs) have been detected in wastewater from waste paper recycling plants. BPA and ClBPAs are always exposed to ultraviolet (UV) radiation in the environment and consequently various photoproducts might be produced. Acute cytotoxicity of photoproducts of BPA and ClBPAs are not ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2005.09.005
更新日期:2006-05-01 00:00:00
abstract::Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, th...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.10.005
更新日期:2013-11-01 00:00:00
abstract::We examined the association between non-occupational exposure to Mn and cognitive functions. The study was carried out in a mining district located in Hidalgo State, Mexico, with 288 adults. Air and blood Mn concentrations were determined, and neuropsychological tests were administered to explore cognitive functions a...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2009.04.001
更新日期:2009-09-01 00:00:00
abstract::A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.06.001
更新日期:2005-01-01 00:00:00
abstract::Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/s1382-6689(97)10020-5
更新日期:1997-12-01 00:00:00
abstract::Most Thai orchid farmers heavily used pesticide mixtures, and were shown to have various hematologic/immunologic alterations. The present study investigated the effect of exposure of male Wistar rats to a mixture of three pesticides (chlorpyrifos, cypermethrin and captan) that are most often used by the farmers. Three...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2018.02.010
更新日期:2018-04-01 00:00:00
abstract::Quantitative structure - activity relationships (QSARs) which are obtained with a representation of the molecular architecture via simplified molecular input-line entry system (SMILES) are applied to build up predictive models of acute toxicity of pesticides towards Daphnia magna. The acute toxicity towards Daphnia ma...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2020.103459
更新日期:2020-11-01 00:00:00
abstract::Recent studies in our laboratory indicated that arsenite at 20μM significantly induces the apoptosis of HUVECs. In this study we analyzed miRNAs expression profiles upon arsenic exposure of these cells to explore the molecular mechanisms of arsenic-induced vascular toxicity. The expression of miRNAs was examined by Ex...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2012.05.003
更新日期:2012-09-01 00:00:00
abstract::Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2015.02.001
更新日期:2015-03-01 00:00:00
abstract::Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this st...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2019.103195
更新日期:2019-08-01 00:00:00
abstract::The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.03.021
更新日期:2013-07-01 00:00:00
abstract::Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2004.12.023
更新日期:2005-05-01 00:00:00
abstract::Colorectal cancer is one of the leading causes of cancer related deaths in Western countries and is becoming increasingly common in Asia. Rosmarinic acid (RA), one of the major components of polyphenol possesses attractive remedial features. The purpose of this study is to investigate the possible chemopreventive mech...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2012.07.014
更新日期:2012-11-01 00:00:00
abstract::Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals (alcohol), xenobiotics (carbon tetrachloride, chlorinated hydrocarbons and gases CO₂ and O₂) anticancer (azathioprine, doxorubicin, cisplatin)...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.etap.2013.08.015
更新日期:2014-01-01 00:00:00
abstract::Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2005.01.008
更新日期:2005-09-01 00:00:00
abstract::A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2017.12.006
更新日期:2018-03-01 00:00:00
abstract::Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2011.12.014
更新日期:2012-03-01 00:00:00
abstract::Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results ...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2018.12.015
更新日期:2019-02-01 00:00:00
abstract::In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/S1382-6689(96)00048-8
更新日期:1996-10-15 00:00:00
abstract::To investigate the regulated role of IL-1β in initiating and maintaining inflammation, PMA-differentiated THP-1 macrophages were exposed to two micro-sized crystalline silica particles (Si3-5μm and Si1μm) from 3h to 24h, respectively. Cytotoxicity and inflammatory cytokines (IL-1β, TNF-α and IL-6) expressions measured...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2014.12.017
更新日期:2015-01-01 00:00:00
abstract::This study is intended to explore effective and sensitive biomarkers for kidney damage after low level arsenic (As) exposure and to provide scientific evidence on cut-off values of arsenic concentrations in drinking water. The levels of α1-MG detected in urine samples were found to have statistically significant diffe...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2013.02.010
更新日期:2013-05-01 00:00:00
abstract::It is well known that developmental exposure to polychlorinated biphenyls (PCBs) could cause learning and memory deficits, but the underlying mechanisms are not clear. Actin cytoskeleton is directly involved in synaptic plasticity which is considered critical to learning and memory formation by LIM kinase 1 (LIMK-1)/c...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2006.08.003
更新日期:2007-03-01 00:00:00
abstract::Environmental Epigenomics is a developing field to study the epigenetic effect on human health from exposure to environmental factors. Endocrine disrupting chemicals have been detected primarily in pharmaceutical drugs, personal care products, food additives, and food containers. Exposure to endocrine-disrupting chemi...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.etap.2017.02.004
更新日期:2017-04-01 00:00:00
abstract::Deoxynivalenol (DON) has broad toxicity in animals and humans. In this study the impact of DON treatment on apoptotic pathways in PC12 cells was determined. The effects of DON were evaluated on (i) typical indicators of apoptosis, including cellular morphology, cell activity, lactate dehydrogenase (LDH) release, and a...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2016.03.016
更新日期:2016-04-01 00:00:00
abstract::The present armamentarium of commercially available antidotes provides limited protection against the neurological effects of organophosphate exposure. Hence, there is an urgent need to design and develop molecules that can protect and reactivate inhibited-AChE in the central nervous system. Some natural compounds lik...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/j.etap.2020.103454
更新日期:2020-11-01 00:00:00
abstract::A series of N(1)-benzylidene pyridine-2-carboxamidrazone anti-tuberculosis compounds has been evaluated for their cytotoxicity using human mononuclear leucocytes (MNL) as target cells. All eight compounds were significantly more toxic than dimethyl sulphoxide control and isoniazid (INH) with the exception of a 4-metho...
journal_title:Environmental toxicology and pharmacology
pub_type: 杂志文章
doi:10.1016/S1382-6689(03)00008-5
更新日期:2003-06-01 00:00:00