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Isoflavones protect against diesel engine exhaust injury in organotypic culture of lung tissue.

Abstract：

:The wide range of potential health beneficial effects of isoflavones, including a chemoprentive action, have prompted us to study the potential benefits of genistein and daidzein in an experimental model of environmental pollution impact on lung tissue. A diesel engine placed was used to generate reproducible emissions including both gaseous and particulate matters that are commonly found in urban atmospheres. Isoflavones were added to culture medium of rat lung slices 2 h prior to their exposure to pollutants for 3 h. Intracellular ATP and GSH levels, TNFα production, nucleosome assay and TUNEL labeling were monitored. Isoflavones showed almost total in vitro protection against inflammatory and pro-apoptotic responses in lung slices. Isoflavones 0.3 and 1 μmol/l protected against exhaust induced GSH depletion. Isoflavones 0.3 μmol/l appeared to exert the most beneficial effects. In conclusion, this study points out the potential interest of soy isoflavones consumption in polluted areas. Further studies should be undertaken to verify that similar effects could be obtained after in vivo administration of isoflavones.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Morin JP,Rumigny JF,Bion A,Dionnet F

doi

10.1016/s1382-6689(02)00066-2

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

213-20

issue

4

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(02)00066-2

journal_volume

12

pub_type

杂志文章

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