Abstract：
:Crops produced through genetic modification are beginning to reach the market and many genetically-modified crops are under development. Since genetic modification results in the introduction of new proteins into the food plant the safety of the newly introduced proteins must be assessed. The potential allergenicity of the newly introduced protein is a major consideration in that safety assessment. All allergens are proteins but only a few of the many proteins found in foods are allergenic. The assessment of the allergenicity of the newly introduced proteins should focus on the source of the gene, the sequence homology of the newly introduced protein to known allergens, the immunochemical reactivity of the newly introduced protein with IgE from the blood serum of individuals with known allergies to the source of the transferred genetic material, and the physicochemical properties of the newly introduced protein.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Taylor SLdoi
10.1016/s1382-6689(97)10052-7subject
Has Abstractpub_date
1997-11-01 00:00:00pages
121-6issue
1-2eissn
1382-6689issn
1872-7077pii
S1382-6689(97)10052-7journal_volume
4pub_type
杂志文章abstract：:In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/S1382-6689(96)00048-8
更新日期：1996-10-15 00:00:00
abstract：:This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.02.001
更新日期：2010-05-01 00:00:00
abstract：:Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.09.022
更新日期：2015-11-01 00:00:00
abstract：:This symposium on susceptibility and risk was the third in a series designed to bring together experts from diverse disciplines to discuss contemporary issues in risk assessment. The topic in 1996 was especially challenging since susceptibility is influenced by a myriad of factors including environmental, genetic, soc...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10010-2
更新日期：1997-12-01 00:00:00
abstract：:The use of surfactants in the development of a suitable formulation for insecticides should improve the solubility behavior, the permeability and the efficiency against pests meanwhile decrease the toxic risks of insecticides on human health. Cytotoxicity of insecticides including abamectin, chlorfluazuron, hexaflumur...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.12.015
更新日期：2015-03-01 00:00:00
abstract：:Epidemiological studies indicate that arsenic exposure induces hypertension. We hypothesized that arsenate exposure modulates the contractility of vascular smooth muscle through the stress response. Intraperitoneal injection of sodium arsenate (15mg/kg) 16h before increased not only the blood pressure of rats but also...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2004.08.002
更新日期：2005-02-01 00:00:00
abstract：:The histopathological effects of deltamethrin on the gill and kidney tissues of the common carp, Cyprinus carpio were determined by light microscopy. The fish were exposed to 0.029mgl(-1) (50% of 96h LC(50)) and 0.041mgl(-1) (70% of 96h LC(50)) solutions of deltamethrin for short-term (96h). The most common gill chang...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2006.03.006
更新日期：2006-09-01 00:00:00
abstract：:Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.02.003
更新日期：2010-05-01 00:00:00
abstract：:We examined the association between non-occupational exposure to Mn and cognitive functions. The study was carried out in a mining district located in Hidalgo State, Mexico, with 288 adults. Air and blood Mn concentrations were determined, and neuropsychological tests were administered to explore cognitive functions a...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.04.001
更新日期：2009-09-01 00:00:00
abstract：:A food allergen may be defined as a substance that reacts with IgE antibodies, induces allergic sensitisation or induces allergic reactions. Some allergens only induce allergic sensitisation but do not provoke symptoms, while others bind IgE but do not induce mast cell degranulation. There is no common structure that ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10042-4
更新日期：1997-11-01 00:00:00
abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.etap.2013.09.014
更新日期：2013-11-01 00:00:00
abstract：:Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103483
更新日期：2020-11-01 00:00:00
abstract：:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.etap.2014.01.024
更新日期：2014-03-01 00:00:00
abstract：:The sensitivity of human lymphocytes from different donors to CdCl2 using a complex of methods for determination of cytotoxicity and genotoxicity was studied. As endpoints for cytotoxicity the mitotic index (MI) and apoptosis were evaluated. To indicate genotoxicity chromosome aberrations test (CA) was used. The resul...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.03.021
更新日期：2013-07-01 00:00:00
abstract：:Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.06.001
更新日期：2009-11-01 00:00:00
abstract：:The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.04.015
更新日期：2017-06-01 00:00:00
abstract：:3-N-Oxalyl-l-2,3-diaminopropanoic acid (β-ODAP) induces neurolathyrism, a motor neuron disease. To elucidate the pathogenic mechanism of this process, the action of β-ODAP on the excitatory amino acid (EAA) receptor-mediated currents was examined using cloned EAA receptors expressed in Xenopus oocytes. On the voltage-...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(96)00067-1
更新日期：1996-12-20 00:00:00
abstract：:Changes in some blood parameters after 12-week administration of sodium metavanadate (SMV; 0.125mgV/ml) or/and magnesium sulphate (MS; 0.06mgMg/ml) in drinking water were studied in outbred male Wistar rats (16 rats/each group) to explore the probable mechanism(s) underlying SMV toxicity and check whether Mg at the le...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2012.04.006
更新日期：2012-09-01 00:00:00
abstract：:Combretastatin A-4 exhibits efficient anti-cancer potential in human tumors, including multidrug-resistant tumors. We evaluated the mutagenic, apoptotic and immunomodulatory potential of two diaryl sulfide analogs of combretastatin A-4, 1,2,3-trimethoxy-5-([4-methoxy-3-nitrophenyl]thio)benzene (analog 1) and 1,2,3-tri...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.08.028
更新日期：2015-11-01 00:00:00
abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2005.01.008
更新日期：2005-09-01 00:00:00
abstract：:In this study, we report the antioxidant and antitoxic potential of chemically synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone (DHF) with two molecules of Fmoc-t...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103425
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.etap.2018.01.006
更新日期：2018-03-01 00:00:00
abstract：:A systematic study on the effects of diuron on the hepatic metabolism was conducted with emphasis on parameters linked to energy metabolism. The experimental system was the isolated perfused rat liver. The results demonstrate that diuron inhibited biosynthesis (gluconeogenesis) and ammonia detoxification, which are de...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.06.024
更新日期：2017-09-01 00:00:00
abstract：:Glyphosate is a broad spectrum herbicide used aggressively in agricultural practices as well as home garden care. Although labeled "safe" by the chemical industry, doses tested by industry do not mimic chronic exposures to sublethal doses that organisms in the environment are exposed to over long periods of time. Give...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.08.010
更新日期：2016-09-01 00:00:00
abstract：:Roundup Original® is an herbicide widely used in Mato Grosso's agriculture and it may contamine water bodies, being an unforeseen xenobiotic to aquatic organisms, particularly fish. This study investigated the effects on the hybrid fish jundiara (Leiarius marmoratus×Pseudoplatystoma reticulatum) of an environmentally ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.09.019
更新日期：2017-12-01 00:00:00
abstract：:Endocrine disrupting chemicals have raised public concern, since their effects have been found to interfere with the physiological systems of various organisms, especially during critical stage of development and reproduction. Endosulfan and malathion, pesticides widely used for agricultural purposes, have been known ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.03.007
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:: Coughing is one of the chronic respiratory symptoms of patients exposed to sulfur mustard (SM) used against Iranian combatants and civilians by Iraq during the Iran-Iraq war, between 1983 and 1989. This study carried out on SM exposed patients who referred to our clinic because of exacerbation of chronic c...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2004.09.006
更新日期：2005-07-01 00:00:00
abstract：:It was evaluated the genotoxicity of glyphosate which up to now has heterogeneous results. The comet assay was performed in Hep-2 cells. The level of DNA damage in the control group (5.42±1.83 arbitrary units) for tail moment (TM) measurements has shown a significant increase (p<0.01) with glyphosate at a range concen...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.02.001
更新日期：2009-07-01 00:00:00
abstract：:The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigo...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：:The metabolites of oestrogenic substances of plant origin, phyto-oestrogens, have been proposed as cancer-protective agents in Asian and vegetarian populations. The two principle classes of these weak oestrogens are isoflavonoids and mammalian lignans. The former is derived from soya-based foods and the latter from oi...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(99)00018-6
更新日期：1999-07-01 00:00:00
