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Anti-leishmanial effect of itraconazole niosome on in vitro susceptibility of Leishmania tropica.

Abstract：

:The novel niosomal system aimed to deliver the active drug entity to the target site. The objective of this study was to prepare and evaluate the effect of itraconazole niosome on the in vitro susceptibility of Leishmania tropica as compared to itraconazole alone or tartar emetic. The overall growth rate of promastigotes treated with various concentrations of itraconazole niosome was significantly lower than that of itraconazole alone (IC₅₀=0.24 μg/ml vs. IC₅₀=0.43 μg/ml, P<0.01). In contrast, the mean multiplication rate of amastigotes inside the macrophages and also the mean number of amastigotes in each macrophage treated with itraconazole niosome (34.9 and 3.0) were significantly lower (P<0.01) than those treated with itraconazole alone (62.0 and 3.8) or tartar emetic (63.9 and 4.2), respectively. These findings indicated that niosomes could be developed as a novel drug delivery for itraconazole in the in vitro model. Further studies are required to evaluate the effect of itraconazole niosome on volunteer human subjects.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Khazaeli P,Sharifi I,Talebian E,Heravi G,Moazeni E,Mostafavi M

doi

10.1016/j.etap.2014.04.003

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

205-11

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00087-8

journal_volume

38

pub_type

杂志文章

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