当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers.

Effect of N-acetylcysteine administration on the expression and activities of antioxidant enzymes and the malondialdehyde level in the blood of lead-exposed workers.

Abstract：

:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two groups. Workers in the first group (reference group, n=49) were not administered any drugs, while workers in the second group (n=122) were treated with NAC at three doses for 12 weeks (200 mg, 400 mg, 800 mg/day). NAC administered orally to lead-exposed workers normalized antioxidant enzyme activities in blood cells. Oxidative stress intensity measured as malondialdehyde (MDA) levels in serum, leukocytes and erythrocytes significantly decreased after NAC administration. NAC may be an alternative therapy for chronic lead intoxication.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Kasperczyk S,Dobrakowski M,Kasperczyk A,Machnik G,Birkner E

doi

10.1016/j.etap.2014.01.024

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

638-47

issue

2

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(14)00026-X

journal_volume

37

pub_type

杂志文章,随机对照试验

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • Deferasirox-induced cytogenetic responses.

    abstract：:Deferasirox (commercially formulated as Exjade(®)) is one of the effective iron chelators used in treatment of iron overload diseases. In this study the effect of this substance for chromosome aberration, sister chromatid exchange and mitotic index was studied by in vitro (by using human peripheral lymphocytes) and in...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.02.001

    authors： Arslan M,Ila HB

    更新日期：2015-03-01 00:00:00

  • Antiangiogenic effects of marine sponge derived compounds on cancer.

    abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.etap.2013.09.014

    authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

    更新日期：2013-11-01 00:00:00

  • Concentrating nanoparticles in environmental monitoring.

    abstract：:There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.06.015

    authors： Cheong BH,Muradoglu M,Liew OW,Ng TW

    更新日期：2015-07-01 00:00:00

  • The potential effects of efavirenz on Oreochromis mossambicus after acute exposure.

    abstract：:Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.09.017

    authors： Robson L,Barnhoorn IEJ,Wagenaar GM

    更新日期：2017-12-01 00:00:00

  • An improved in vitro method for screening toxin and medicine targeting CYP2E1.

    abstract：:The cytochrome P450 enzyme 2E1 (CYP2E1) presents in both microsome and mitochondrion, which influences the metabolism of many xenobiotics. The mice active liver homogenate was prepared for the medicinal incubation and mitochondrion was extracted for chemical screening targeting CYP2E1 enzyme. Representative CYP2E1 ind...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.09.006

    authors： Wang M,Zhou Z,Wang J,Zhang X

    更新日期：2016-10-01 00:00:00

  • Acetylsalicylic acid and ascorbic acid combination improves cognition; via antioxidant effect or increased expression of NMDARs and nAChRs?

    abstract：:Chronic inflammation occurs systematically in the central nervous system during ageing, it has been shown that neuroinflammation plays an important role in the pathogenesis of many neurodegenerative disorders. Aspirin, a nonselective COX inhibitor, as well as ascorbic acid, has been purported to protect cerebral tissu...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.02.019

    authors： Kara Y,Doguc DK,Kulac E,Gultekin F

    更新日期：2014-05-01 00:00:00

  • Effects of perfluorooctane sulfonate on mallard and northern bobwhite quail exposed chronically via the diet.

    abstract：:Adult mallard ducks and northern bobwhite quail were exposed to 0, 10, 50, or 150mg perfluorooctane sulfonate (PFOS)/kg in the diet for up to 21 weeks. Adult health, body and liver weight, feed consumption, gross morphology and histology of body organs, and reproduction were examined. Due to mortality, birds exposed t...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2006.04.008

    authors： Newsted JL,Coady KK,Beach SA,Butenhoff JL,Gallagher S,Giesy JP

    更新日期：2007-01-01 00:00:00

  • The organochlorine pesticides pentachlorophenol and dichlorodiphenyltrichloroethane increase secretion and production of interleukin 6 by human immune cells.

    abstract：:The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulat...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103263

    authors： Martin TJ,Gabure S,Maise J,Snipes S,Peete M,Whalen MM

    更新日期：2019-11-01 00:00:00

  • The role of 3-methylsulfonyl-2,2',4',5,5'-pentachlorobiphenyl, a metabolite of 2,2',4,5,5'-pentachlorobiphenyl, in the induction of hepatic microsomal drug-metabolizing enzymes by 2,2',4,5,5'-pentachlorobiphenyl in rats.

    abstract：:After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(99)00028-9

    authors： Kato Y,Haraguchi K,Tomiyasu K,Saito H,Shibahara T,Masuda Y,Kimura R

    更新日期：1999-12-01 00:00:00

  • Fate of psychoactive compounds in wastewater treatment plant and the possibility of their degradation using aquatic plants.

    abstract：:In this study we analyzed and characterized 29 psychoactive remedies, illicit drugs and their metabolites in single stages of wastewater treatment plants in the capital city of Slovakia. Psychoactive compounds were present within all stages, and tramadol was detected at a very high concentration (706 ng/L). Significan...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.02.018

    authors： Mackuľak T,Mosný M,Škubák J,Grabic R,Birošová L

    更新日期：2015-03-01 00:00:00

  • The genotoxicity of diaveridine and trimethoprim.

    abstract：:We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the um...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)00026-4

    authors： Ono T,Sekiya T,Takahashi Y,Sasaki YF,Izumiyama F,Nishidate E,Tsuda S,Ohta T

    更新日期：1997-09-01 00:00:00

  • Acute exposure to 50ppm toluene does not increase sleepiness.

    abstract：:The Pupillographic Sleepiness Test (PST) is a new neurophysiological method to assess sleepiness. In an exposure study to a constant exposure level of 50ppm toluene on 20 healthy men, our aim was to find out, if increased sleepiness could be seen with PST. PST was performed before and after 4.5h of exposure. General c...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2004.12.034

    authors： Muttray A,Spelmeyer U,Hommel G,Oesch F,Jung D,Rose DM,Mayer-Popken O,Rossbach B,Letzel S

    更新日期：2005-05-01 00:00:00

  • Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens.

    abstract：:Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35day...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.07.011

    authors： Bai S,Pan S,Zhang K,Ding X,Wang J,Zeng Q,Xuan Y,Su Z

    更新日期：2017-09-01 00:00:00

  • Sociodemographic aspects of human susceptibility to toxic chemicals: Do class and race matter for realistic risk assessment?

    abstract：:Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)10020-5

    authors： Sexton K

    更新日期：1997-12-01 00:00:00

  • Assessment of genotoxicity of four volatile pollutants from cigarette smoke based on the in vitro γH2AX assay using high content screening.

    abstract：:To evaluate the genotoxic effects of formaldehyde, acetaldehyde, acrolein and benzene on A549 cells, the in vitro γH2AX assay was used in combination with high content screening (HCS) technology. All aldehydes showed a significant genotoxicity in a dose/time-dependent effect on the induction of γH2AX. Benzene failed t...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.07.005

    authors： Zhang S,Chen H,Wang A,Liu Y,Hou H,Hu Q

    更新日期：2017-10-01 00:00:00

  • Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine.

    abstract：:Poisoning by organophosphorus insecticides is a major global public health problem. Although atropine has been widely used to treat organophosphate (OP) poisoning, sometimes atropinization cannot be achieved, even with high doses of atropine. Hence, we aimed to assess the effect of anisodamine for organophosphorus poi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.12.016

    authors： Wang W,Chen QF,Li QB,Wu YB,Chen K,Chen B,Wen JM

    更新日期：2014-03-01 00:00:00

  • The effect of water soluble cyanotoxin(s) produced by two species of Anabaena on the release of acetylcholine from the peripheral cholinergic nervous system of the rat airway.

    abstract：:A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)10007-2

    authors： Ruge Holte H,Eriksen S,Skulberg O,Aas P

    更新日期：1998-01-01 00:00:00

  • Genes regulating wing patterning in Drosophila melanogaster show reduced expression under exposure of Daminozide, the fruit ripening retardant.

    abstract：:In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2019.103322

    authors： Roy SS,Ghosh S

    更新日期：2020-04-01 00:00:00

  • Activity of the enzymes of the antioxidative system in cadmium-treated Oxya chinensis (Orthoptera Acridoidae).

    abstract：:One purpose in this research was to determine the toxic effects of Cd on antioxidant enzymes of Oxya chinensis (Orthoptera: Acridoidae). Changes in the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (GPx) were measured in O. chinensis insects injected with Cd(...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.04.001

    authors： Lijun L,Xuemei L,Yaping G,Enbo M

    更新日期：2005-11-01 00:00:00

  • A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

    abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.025

    authors： Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

    更新日期：2018-03-01 00:00:00

  • Food from genetically modified organisms and potential for food allergy.

    abstract：:Crops produced through genetic modification are beginning to reach the market and many genetically-modified crops are under development. Since genetic modification results in the introduction of new proteins into the food plant the safety of the newly introduced proteins must be assessed. The potential allergenicity o...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)10052-7

    authors： Taylor SL

    更新日期：1997-11-01 00:00:00

  • Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area.

    abstract：:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in indivi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.10.016

    authors： Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

    更新日期：2015-01-01 00:00:00

  • In situ assessment of Karaj River genotoxic impact with the alkaline comet assay and micronucleus test, on feral brown trout (Salmo trutta fario).

    abstract：:The in situ evaluation of the genotoxic impact of the Karaj River was performed using the comet and micronucleus (MN) assays in erythrocytes, liver, gill and kidney of indigenous brown trout, Salmo trutta fario from three different stations, including Varangerud, Asara and Purkan. The results showed that DNA damage si...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.024

    authors： Hariri M,Mirvaghefi A,Farahmand H,Taghavi L,Shahabinia AR

    更新日期：2018-03-01 00:00:00

  • Application of the yeast-based reporter gene bioassay for the assessment of estrogenic activity in cow's milk from Poland.

    abstract：:Milk contain compounds acting through the estrogen receptor signaling. The still open question whether such estrogens pose a risk for human health, encouraged us to measure the overall estrogenic activity of cow's milk in the in vitro yeast reporter bioassay. First, we assessed the ability of the bioassay to detect es...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.09.022

    authors： Stypuła-Trębas S,Minta M,Radko L,Żmudzki J

    更新日期：2015-11-01 00:00:00

  • Assessment of pulmonary toxicity of gold nanorods following intra-tracheal instillation in rats.

    abstract：:The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.04.015

    authors： Lingabathula H,Yellu N

    更新日期：2017-06-01 00:00:00

  • Strain differences in age-associated change in testosterone 6β-hydroxylation in Wistar and Dark Agouti rats.

    abstract：:This study examines strain differences in testosterone (T)-hydroxylations between Wistar and Dark Agouti (DA) rats of both genders. The DA rat, an animal model, is a poor metabolizer of such drugs as debrisoquine, which are metabolized by cytochrome P450 (CYP) 2D. T-16α-, 2α-hydroxylations, which are linked to CYP2C11...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(96)00130-5

    authors： Maeda Y,Morita K,Tasaki T,Kazusaka A,Imaoka S,Funae Y,Fujita S

    更新日期：1997-02-15 00:00:00

  • Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent.

    abstract：:Arsenic (As) widely studied for its effects as a neurotoxicant. The present study was designed to evaluate the protective effect of calcium, zinc or monoisoamyl dimercaptosuccinic acid (MiADMSA), either individually or in combination on As induced oxidative stress and apoptosis in brain regions (cerebral cortex, hippo...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.09.021

    authors： Kadeyala PK,Sannadi S,Gottipolu RR

    更新日期：2013-11-01 00:00:00

  • Biological effects of tris (1-chloro-2-propyl) phosphate (TCPP) on immunity in mussel Mytilus galloprovincialis.

    abstract：:Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological eff...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.05.022

    authors： Wu H,Zhong M,Lu Z,Shan X,Li F,Ji C,Cong M

    更新日期：2018-07-01 00:00:00

  • Function of respiratory system evaluated using selected spirometry parameters in persons occupationally exposed to lead without evident health problems.

    abstract：UNLABELLED:This study aimed at evaluation of selected spirometric parameters in persons occupationally exposed to lead without evident health problems. The studies were conducted on 69 men occupationally exposed to lead. Occupational exposure to lead was characterized by estimation of blood lead concentration (Pb-B) an...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.03.009

    authors： Jurdziak M,Gać P,Martynowicz H,Poręba R

    更新日期：2015-05-01 00:00:00

  • The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial.

    abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.etap.2018.01.006

    authors： Khazdair MR,Rajabi O,Balali-Mood M,Beheshti F,Boskabady MH

    更新日期：2018-03-01 00:00:00