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Methylation of cytochrome p450 2E1 promoter induced by low dosage of isoniazid.

Abstract：

BACKGROUND AND AIMS:To find new diagnostic markers to monitor isoniazid-induced liver injury. METHODS:SD rats were treated with low dosage of isoniazid and the light microscopic findings of livers were collected. The methylation status of cytochrome p450 2E1 promoter was determined. RESULTS:Cell edema and spotty necrosis on liver cells appeared in the experimental group and promoter methylation of cytochrome p450 2E1 was detected. CONCLUSIONS:Low-dosage isoniazid can induce liver injury.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Shen L,Zhang B,Sun S,Feng F

doi

10.1016/j.etap.2013.03.016

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

149-51

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(13)00075-6

journal_volume

36

pub_type

杂志文章

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