当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.

Models of hepatotoxicity and the underlying cellular, biochemical and immunological mechanism(s): a critical discussion.

Abstract：

:Liver is a primary organ involved in biotransformation of food and drugs. Hepatic diseases are a major worldwide problem. Hepatic disorders are mainly caused by toxic chemicals (alcohol), xenobiotics (carbon tetrachloride, chlorinated hydrocarbons and gases CO₂ and O₂) anticancer (azathioprine, doxorubicin, cisplatin), immunosuppressant (cyclosporine), analgesic anti-inflammatory (paracetamol, thioacetamide), anti-tubercular (isoniazid, rifampicin) drugs, biologicals (Bacillus-Calmette-Guerin vaccine), radiations (gamma radiations), heavy metals (cadmium, arsenic), mycotoxin (aflatoxin), galactosamine, lipopolysaccharides, etc. Various risk factors for hepatic injury include concomitant hepatic diseases, age, gender, alcoholism, nutrition and genetic polymorphisms of cytochrome P450 enzymes have also been emphasized. The present review enumerates various in vivo animal models and in vitro methods of hepatic injury using diverse toxicants, their probable metabolic pathways, and numerous biochemical changes viz. serum biomarkers enzymes, liver function, oxidative stress associated events like free radicals formation, lipid peroxidation, enzyme antioxidants and participation of cytokines (tumour necrosis factor-α, transforming growth factor-β, tumour necrosis factor-related apoptosis inducing ligand), and other biomolecules (Fas and C-jun N-terminal kinase) are also discussed. The underlying cellular, molecular, immunological, and biochemical mechanism(s) of action responsible for liver damage (toxicity) are also been discussed. This review should be immensely useful for researchers especially for phytochemists, pharmacologists and toxicologists working on hepatotoxicity, hepatotoxic chemicals and drugs, hepatoprotective agents and drug research organizations involved especially in phytopharmaceuticals and other natural products.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Ingawale DK,Mandlik SK,Naik SR

doi

10.1016/j.etap.2013.08.015

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

118-33

issue

1

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(13)00195-6

journal_volume

37

pub_type

杂志文章,评审

相关文献

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY文献大全
  • A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.

    abstract：:The pathogenesis of atopic dermatitis (AD) involves T helper 2 (Th2) cells, and effective therapies remain elusive due to the paucity of animal models. We aimed to develop a mouse model of an immune system aberration caused by allergen. Experiments were conducted in two phases. In experiment 1, BALB/c mice were sensit...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.12.025

    authors： Park HJ,Choi WS,Lee WY,Choi Y,Park C,Kim JH,Hong KH,Song H

    更新日期：2018-03-01 00:00:00

  • Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio (Pistacia vera L.) cultivars collected from four geographical regions of Iran.

    abstract：:Iran is one of the main suppliers of pistachio for the European market accounting for over 90% of its demands; hence, efficient analytical methods are required for detection of mycotoxins contamination in pistachio kernels before exporting them. In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.05.010

    authors： Taghizadeh SF,Rezaee R,Davarynejad G,Asili J,Nemati SH,Goumenou M,Tsakiris I,Tsatsakis AM,Shirani K,Karimi G

    更新日期：2018-07-01 00:00:00

  • Analysis of phyto-oestrogens by gas chromatography-mass spectrometry.

    abstract：:The metabolites of oestrogenic substances of plant origin, phyto-oestrogens, have been proposed as cancer-protective agents in Asian and vegetarian populations. The two principle classes of these weak oestrogens are isoflavonoids and mammalian lignans. The former is derived from soya-based foods and the latter from oi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(99)00018-6

    authors： Morton M,Arisaka O,Miyake A,Evans B

    更新日期：1999-07-01 00:00:00

  • The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.

    abstract：OBJECTIVES:Acetaminophen (APAP) overdose may cause acute liver injury. Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities. Thus, we have designed this study to evaluate the efficacy of OT in a rat model of APAP-induced liver injury. METHODS:Twenty-seven Sprague-Dawley rats were divided...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.02.006

    authors： Gul H,Uysal B,Cakir E,Yaman H,Macit E,Yildirim AO,Eyi YE,Kaldirim U,Oztas E,Akgul EO,Cayci T,Ozler M,Topal T,Oter S,Korkmaz A,Toygar M,Demirbag S

    更新日期：2012-07-01 00:00:00

  • Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats.

    abstract：:The protective effects of lobenzarit disodium against the toxicity of allyl alcohol were investigated in vitro using isolated rat hepatocytes and in vivo using mice. In mice, at i.p doses of 25, 50 and 100 mg/kg lobenzarit significantly decreased the activity of alanine amino transferase (ALT) in serum and the concent...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/s1382-6689(97)00149-x

    authors： Remirez D,Commandeur JN,Groot E,Gonzalez R,Rodriguez S,Ancheta O,Rojas E,Ramos ME,Vermeulen NP

    更新日期：1997-06-06 00:00:00

  • Screening estrogenic oxidized by-products by combining ER binding and ultrafiltration.

    abstract：:Ozonation and chlorination of 17β-estradiol (E2), 17α-ethynylestradiol (EE2), bisphenol A (BPA), and nonylphenol (NP) were performed to evaluate the estrogenic activity of the by-products of these endocrine disrupting chemicals (EDCs). After 15min oxidation, samples were extracted using solid phase extraction (SPE) ca...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2005.01.008

    authors： Liu J,Carr S,Rinaldi K,Chandler W

    更新日期：2005-09-01 00:00:00

  • A metabolic profiling analysis of the nephrotoxicity of acyclovir in rats using ultra performance liquid chromatography/mass spectrometry.

    abstract：:Acyclovir (ACV) exposure is a common cause of acute kidney injury (AKI). The toxicity mechanism of ACV has always been a matter of debate. The present study investigated into the time-effect relationship and dose-effect relationship of ACV-induced nephrotoxicity in rats using metabonomics. Twenty-four rats were random...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2016.07.018

    authors： Xing W,Gu L,Zhang X,Xu J,Lu H

    更新日期：2016-09-01 00:00:00

  • Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (Danio rerio) livers.

    abstract：:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, r...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.018

    authors： Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Y

    更新日期：2017-04-01 00:00:00

  • Blood selenium concentration in a selected population of children inhabiting industrial regions in Upper Silesia (Poland).

    abstract：PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2012.06.005

    authors： Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

    更新日期：2012-09-01 00:00:00

  • Cell metabolic changes of porphyrins and superoxide anions by anthracene and benzo(a)pyrene.

    abstract：:The aim of this work was to evaluate the induction of protoporphyrins IX (PpIX) activity and superoxide anions (SO) in human leukocytes exposed to anthracene (ANT) and benzo(a)pyrene (B(a)P). The leukocyte LC(50)s for both hydrocarbons and the PpIX accumulation and SO overproduction were measured. The LC(50)s were 0.3...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.05.002

    authors： Uribe-Hernández R,Pérez-Zapata AJ,Vega-Barrita ML,Ramón-Gallegos E,Amezcua-Allieri MA

    更新日期：2008-09-01 00:00:00

  • Zizyphus jujuba and Origanum majorana extracts protect against hydroquinone-induced clastogenicity.

    abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.07.002

    authors： Ghaly IS,Said A,Abdel-Wahhab MA

    更新日期：2008-01-01 00:00:00

  • Concentrating nanoparticles in environmental monitoring.

    abstract：:There are significant challenges in assessing the toxicity of nanoparticles in the environment in which effective methods for detection are crucial. An inexpensive method that uses superhydrophobic well with an evaporating droplet followed by a simple squeeze flow is described here and found to provide practical high ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.06.015

    authors： Cheong BH,Muradoglu M,Liew OW,Ng TW

    更新日期：2015-07-01 00:00:00

  • Effects of atrazine and chlorpyrifos on activity and transcription of glutathione S-transferase in common carp (Cyprinus carpio L.).

    abstract：:Glutathione S-transferase isoenzymes (GSTs) play a critical role in detoxification pathways. Here we report the tissue distribution of four antioxidant GSTs gene in common carp, and their expression profiles. We also investigated the GSTs activity in different tissues after exposure to the agricultural chemicals atraz...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.014

    authors： Xing H,Wang X,Sun G,Gao X,Xu S,Wang X

    更新日期：2012-03-01 00:00:00

  • Pharmacokinetic profile of cefquinome after oral subchronic flubendiamide exposure and in vitro plasma protein binding in buffalo calves.

    abstract：:The disposition kinetics study of cefquinome was conducted following single intravenous (IV) administration of 2mg/kg bodyweight in buffalo calves after oral subchronic exposure to flubendiamide and to determine the in vitro plasma protein binding of cefquinome. Plasma concentrations of cefquinome were analyzed using ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.12.004

    authors： Venkatachalam D,Dumka VK

    更新日期：2015-01-01 00:00:00

  • Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3.

    abstract：:Cadmium (Cd) is a major pollutant of environment. It can be fatal to human. In spite of bulk of research and literatures, the mechanism of a fatality against human is still not understood completely. Toxic and carcinogenic effects of Cd in rodents and humans are well known. However, effects of Cd on induction of apopt...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2013.09.006

    authors： Al-Assaf AH,Alqahtani AM,Alshatwi AA,Syed NA,Shafi G,Hasan TN

    更新日期：2013-11-01 00:00:00

  • Ardipusilloside I induces apoptosis in human glioblastoma cells through a caspase-8-independent FasL/Fas-signaling pathway.

    abstract：:Ardipusilloside I, a triterpenoid saponin isolated from Ardisia pusilla A. DC, suppresses the growth of a variety of cancer cells, and has certain immunomodulative properties. Herein, we investigated its effect on glioblastoma cell line U87MG cells and primary cultured human glioblastoma cells, and examined the underl...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.11.008

    authors： Xiong J,Cheng G,Tang H,Zhen HN,Zhang X

    更新日期：2009-03-01 00:00:00

  • Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation.

    abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2018.09.012

    authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

    更新日期：2018-12-01 00:00:00

  • Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental nephritis.

    abstract：UNLABELLED:The present research introduces the method of Production of M2000 (β-d-mannuronic acid) and its therapeutic effect on experimental model of nephritis. M2000 was produced using enzymatic and chemical procedure on prepared alginate from Pseudomonas fluorescens. The experimental glomerulonephritis was induced i...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2007.02.002

    authors： Mirshafiey A,Rehm B,Abhari RS,Borzooy Z,Sotoude M,Razavi A

    更新日期：2007-07-01 00:00:00

  • Protection of Flos Lonicerae against acetaminophen-induced liver injury and its mechanism.

    abstract：:This study aims to observe the protective action of Flos Lonicerae (FL) aqueous extract against acetaminophen (AP)-induced liver injury and its mechanism. Results show that FL decreases AP-increased serum alanine/aspartate transaminases (ALT/AST) activity, as well as total bilirubin (TB) amount, in mice. Histological ...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.10.019

    authors： Jiang P,Sheng YC,Chen YH,Ji LL,Wang ZT

    更新日期：2014-11-01 00:00:00

  • The effect of Zataria multiflora on pulmonary function tests, hematological and oxidant/antioxidant parameters in sulfur mustard exposed veterans, a randomized doubled-blind clinical trial.

    abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.etap.2018.01.006

    authors： Khazdair MR,Rajabi O,Balali-Mood M,Beheshti F,Boskabady MH

    更新日期：2018-03-01 00:00:00

  • Involvement of mitochondrial ATP-sensitive potassium channels in etomidate preconditioning-induced protection in human myeloid HL-60 cells.

    abstract：:Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.02.003

    authors： Zhang X,Xiong J,Jiao Y,Wang G,Zuo Z

    更新日期：2010-05-01 00:00:00

  • Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice.

    abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.10.002

    authors： Chung JW,Shin JE,Han KW,Ahn JH,Kim YJ,Park JW,So HS

    更新日期：2011-01-01 00:00:00

  • Disposition kinetics of selenium in healthy volunteers following therapeutic shampoo treatment.

    abstract：:This study was aimed at documenting the kinetic time courses of selenium (Se) in accessible biological matrices of volunteers following controlled applications of therapeutic shampoo containing Se, to better elucidate the mechanisms by which shampoo-Se accumulates in hair and hence estimate the contribution of this so...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2010.02.001

    authors： Noisel N,Bouchard M,Carrier G

    更新日期：2010-05-01 00:00:00

  • The role of african american ethnicity and metabolism in sentinel polychlorinated biphenyl congener serum levels.

    abstract：:Polychlorinated biphenyls (PCBs) are environmental contaminants found in the serum of human populations across the globe. A small set of sentinel PCB congeners (IUPAC# 101, 118, 138, 153, and 180) commonly sought in human serum are often used as markers of exposure. The Chicago Great Lakes cohort of pregnant African A...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2008.08.008

    authors： McGraw JE,Waller DP

    更新日期：2009-01-01 00:00:00

  • Temporal changes in urinary levels of cadmium, N-acetyl-β-d-glucosaminidase and β2-microglobulin in individuals in a cadmium-contaminated area.

    abstract：:Cadmium (Cd) is a metal that is toxic to renal tubules. If renal tubules are damaged by Cd, urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) and beta 2-microglobulin (β2-MG) increases. The aim of this study was to describe the changing patterns of urinary Cd, NAG, and β2-MG levels over a 3-year period in indivi...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2014.10.016

    authors： Kim YD,Yim DH,Eom SY,Moon SI,Park CH,Kim GB,Yu SD,Choi BS,Park JD,Kim H

    更新日期：2015-01-01 00:00:00

  • Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats.

    abstract：:The Opuntia ficus indica f. inermis methanolic flowers extract (OMFE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, linoleic acid peroxidation assays and in vivo evaluated for its ability to prevent ethanol-induced gastri...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.08.007

    authors： Alimi H,Hfaiedh N,Bouoni Z,Sakly M,Ben Rhouma K

    更新日期：2011-11-01 00:00:00

  • Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of Aβ peptide in rats.

    abstract：:Fucoidan is a complex sulfated polysaccharide, derived from marine brown seaweed. In the present study, we investigated the effects of fucoidan on improving learning and memory impairment in rats induced by infusion of Aβ (1-40), and its possible mechanisms. The results indicated that fucoidan could ameliorate Aβ-indu...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2011.12.022

    authors： Gao Y,Li C,Yin J,Shen J,Wang H,Wu Y,Jin H

    更新日期：2012-03-01 00:00:00

  • Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity.

    abstract：:Alpha-lipoic acid (α-LA) is an important antioxidant that is capable of regenerating other antioxidants, such as glutathione (GSH). However, the underlying molecular mechanism by which α-LA regenerates GSH remains poorly understood. The current study aimed to investigate whether α-LA regenerates GSH by activation of N...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2017.02.022

    authors： Zhang J,Zhou X,Wu W,Wang J,Xie H,Wu Z

    更新日期：2017-04-01 00:00:00

  • Fate of psychoactive compounds in wastewater treatment plant and the possibility of their degradation using aquatic plants.

    abstract：:In this study we analyzed and characterized 29 psychoactive remedies, illicit drugs and their metabolites in single stages of wastewater treatment plants in the capital city of Slovakia. Psychoactive compounds were present within all stages, and tramadol was detected at a very high concentration (706 ng/L). Significan...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2015.02.018

    authors： Mackuľak T,Mosný M,Škubák J,Grabic R,Birošová L

    更新日期：2015-03-01 00:00:00

  • Enhancement of FcɛRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate.

    abstract：:The effect of two fluorosurfactants, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), on degranulation of rat basophilic leukemia RBL2H3 cells was investigated. PFOA and PFOS promoted IgE-mediated release of granule components of RBL2H3 cells at 10-300μM. At low concentrations (<30μM), the fluorosur...

    journal_title：Environmental toxicology and pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.etap.2009.12.009

    authors： Yamaki K,Yoshino S

    更新日期：2010-03-01 00:00:00