Abstract:
:The present study examined the potential toxicity of 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) and 1-butyl-3- methylimidazolium tetrafluoroborate ([Bmim]BF4) in the liver cells of zebrafish (Danio rerio) with different doses (20-160mg/L) on 7 and 14days. The effects of [Bmim]Cl and [Bmim]BF4 on acute toxicity, reactive oxygen species (ROS), antioxidant enzymes, glutathione S-transferase (GST), malondialdehyde (MDA), and DNA damage degree in livers of zebrafish were determined. The 50% lethal concentration (LC50) values after a 96-h exposure to [Bmim]Cl and [Bmim]BF4 were 632.8±67.4 and 604.6±56.2mg/L, respectively, which indicated that the substances were practically harmless. The minor discrepancy may be caused by the different anions. The ROS levels were dose-dependent, which may cause the inhibition of antioxidant enzyme activity, lipid peroxidation, DNA damage and the stimulation of detoxifying enzyme activity. The present study can also provide scientific support for the future selection and evaluation of ionic liquids (ILs).
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Zhang C,Shao Y,Zhu L,Wang J,Wang J,Guo Ydoi
10.1016/j.etap.2017.02.018subject
Has Abstractpub_date
2017-04-01 00:00:00pages
131-137eissn
1382-6689issn
1872-7077pii
S1382-6689(17)30059-5journal_volume
51pub_type
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