Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis.

abstract：:This study evaluated the effect of paraquat (PQ) and temperature on hematological parameters and nonspecific immune system of fish Colossoma macropomum (Cachama). Juveniles were used for all experiments. Fish were exposed to three temperatures (18, 28, 35°C) and 10mg/L PQ during 21 days (PQ LC(50) 96h was of 48.05mg/L...

journal_title：Environmental toxicology and pharmacology

authors： Salazar-Lugo R,Estrella A,Oliveros A,Rojas-Villarroel E,Villalobos de B L,Lemus M

更新日期：2009-05-01 00:00:00

abstract：:Bisphenol-A (BPA) has been classified as an endocrine disruptor which disrupts normal cell function by acting as an estrogen agonist. Environmentally relevant doses of the Bisphenol-A have profound effects on rat endocrine pancreas, an essential organ involved in glucose homeostasis. Bisphenol-A acts on insulin releas...

journal_title：Environmental toxicology and pharmacology

authors： Jayashree S,Indumathi D,Akilavalli N,Sathish S,Selvaraj J,Balasubramanian K

更新日期：2013-03-01 00:00:00

abstract：:The protection of human health from the adverse effects of cumulative environmental exposure to chemical mixtures is an important issue. Of particular interest is the detection and characterization of interaction among chemicals in complex mixtures. Response surface methodology, often supported by factorial designs, i...

journal_title：Environmental toxicology and pharmacology

authors： Gennings C,Carter WH Jr,Casey M,Moser V,Carchman R,Simmons JE

更新日期：2004-11-01 00:00:00

abstract：:The impact of commonly used pesticides, endosulfan and deltamethrin, on the molecular stress level in black tiger shrimp Penaeus monodon, was assessed using classical oxidative stress biomarkers, protein carbonylation profiles, and levels of heat shock proteins. Results showed that 4 days exposure to 0.1 μg L(-1) delt...

journal_title：Environmental toxicology and pharmacology

authors： Dorts J,Silvestre F,Tu HT,Tyberghein AE,Phuong NT,Kestemont P

更新日期：2009-09-01 00:00:00

abstract：:Structural analogs of bisphenol A are commonly used as its alternatives in industrial and commercial applications. Nevertheless, the question arises whether the use of other bisphenols is justified as replacements for bisphenol A in mass production of plastic materials. To evaluate the influence of metabolic reactions...

journal_title：Environmental toxicology and pharmacology

authors： Gramec Skledar D,Peterlin Mašič L

更新日期：2016-10-01 00:00:00

abstract：:Insulin resistance and risk of type 2 diabetes are the most important complications following exposure to organophosphorous (OPs) pesticides. Regarding the importance of liver on metabolic pathways regulation, in particular blood glucose homeostasis, we focused on liver inflammation and oxidative damages in a subchron...

journal_title：Environmental toxicology and pharmacology

authors： Lasram MM,Dhouib IB,Bouzid K,Lamine AJ,Annabi A,Belhadjhmida N,Ahmed MB,Fazaa SE,Abdelmoula J,Gharbi N

更新日期：2014-09-01 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...

journal_title：Environmental toxicology and pharmacology

authors： Jung HY,Seo DW,Hong CO,Kim JY,Yang SY,Lee KW

更新日期：2015-01-01 00:00:00

abstract：:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...

journal_title：Environmental toxicology and pharmacology

authors： Zhang T,Li X,Min X,Fang T,Zhang Z,Yang L,Liu P

更新日期：2012-05-01 00:00:00

abstract：:Today a variety of endocrine disrupting chemicals (EDCs) are recognized in the group of metabolic disruptors, a wide range of environmental contaminants that alter energy balance regulation by affecting the peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) pathway. Herein, we investigated the...

journal_title：Environmental toxicology and pharmacology

authors： Cocci P,Mozzicafreddo M,Angeletti M,Mosconi G,Palermo FA

更新日期：2017-10-01 00:00:00

abstract：:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenes...

journal_title：Environmental toxicology and pharmacology

authors： Anbarasi K,Sabitha KE,Devi CS

更新日期：2005-09-01 00:00:00

abstract：:This study aims to investigate potential toxic effects of chrysene (CHR) on mature scallop Chlamys farreri during the reproduction period, using indicators of antioxidant defences and oxidative stress. Scallops were exposed to 0.2, 0.8 and 3.2μg/L waterborne CHR for 21 days, at day 10 scallops were induced to spawn. A...

journal_title：Environmental toxicology and pharmacology

authors： Xiu M,Pan L,Jin Q

更新日期：2016-06-01 00:00:00

abstract：:Recent findings of high levels of predominantly lower chlorinated biphenyls in indoor and outdoor air open the question of possible health consequences. Lower chlorinated biphenyls are more readily metabolized to reactive and potentially harmful intermediates, acting as mutagens and cancer initiators. The goal of this...

journal_title：Environmental toxicology and pharmacology

authors： Maddox C,Wang B,Kirby PA,Wang K,Ludewig G

更新日期：2008-03-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric c...

journal_title：Environmental toxicology and pharmacology

authors： Pohanka M

更新日期：2014-01-01 00:00:00

abstract：:Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

journal_title：Environmental toxicology and pharmacology

authors： Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

更新日期：2012-03-01 00:00:00

abstract：:Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

journal_title：Environmental toxicology and pharmacology

authors： Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

更新日期：2016-03-01 00:00:00

abstract：:Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...

journal_title：Environmental toxicology and pharmacology

authors： Sexton K

更新日期：1997-12-01 00:00:00

abstract：:In this study, the effects of acute and subacute formaldehyde (FA) exposures on spontaneous locomotor activity (SLMA), wet dog shake (WDS) behavior and pentylenetetrazole (PTZ) induced seizures were evaluated in Balb/C mice. SLMA was concentration dependently reduced after acute FA exposures at 1.8, 3.2, 4.5, 6.4, 9.7...

journal_title：Environmental toxicology and pharmacology

authors： Usanmaz SE,Akarsu ES,Vural N

更新日期：2002-03-01 00:00:00

abstract：:A water extract of the lyophilised fresh-water alga Anabaena flos-aquae enhanced substantially the release of [(3)H]acetylcholine ([(3)H]acetylcholine and [(3)H]choline) from cholinergic nerves of rat bronchi. Parallel experiments performed with the related species Anabaena lemmermannii did not demonstrate this effect...

journal_title：Environmental toxicology and pharmacology

authors： Ruge Holte H,Eriksen S,Skulberg O,Aas P

更新日期：1998-01-01 00:00:00

abstract：:In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mou...

journal_title：Environmental toxicology and pharmacology

authors： Kang MC,Kang SM,Ahn G,Kim KN,Kang N,Samarakoon KW,Oh MC,Lee JS,Jeon YJ

更新日期：2013-05-01 00:00:00

abstract：:The term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis a...

journal_title：Environmental toxicology and pharmacology

authors： Senthilkumar K,Venkatesan J,Manivasagan P,Kim SK

更新日期：2013-11-01 00:00:00

abstract：:The toxicokinetic characteristics of naringin were investigated in rats that had been orally administered naringin extract, a candidate for oral treatment of cough, prepared from Citrus grandis "Tomentosa", at 50, 250, or 1250 mg/kg/day in a repeated-dose study for 1, 32, 93, or 184 days. Increased values of the mean ...

journal_title：Environmental toxicology and pharmacology

authors： Liu M,Yang C,Zou W,Guan X,Zheng W,Lai L,Fang S,Cai S,Su W

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Sulfur mustard is an alkylating agent which cause to short and long term incapacitations on various organs including lung. There is no definite treatment for lung disorders induced by SM exposure. In the present study, the preventive effect of Zataria multiflora (Z. multiflora) on hematological parameters, o...

journal_title：Environmental toxicology and pharmacology

authors： Khazdair MR,Rajabi O,Balali-Mood M,Beheshti F,Boskabady MH

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Present study aimed at determining blood selenium concentration (Se-B) in a selected population of children inhabiting industrial regions. METHODS:The studies were conducted on a group of 267 children inhabiting industrial regions in Upper Silesia (Poland). Determination of Se-B was performed using hydride gen...

journal_title：Environmental toxicology and pharmacology

authors： Gać P,Pawlas N,Poręba R,Poręba M,Prokopowicz A,Pawlas K

更新日期：2012-09-01 00:00:00

abstract：:Epidemiological and experimental studies have demonstrated that cigarette smoking intensifies gastric ulceration. Although nicotine can act as an anxiolytic and antidepressant, its withdrawal may also lead to increased anxiety and depression. In order to associate the toxic actions of nicotine on gastric mucosa with a...

journal_title：Environmental toxicology and pharmacology

authors： Deniz M,Sahin HH,Tekin S,Yeşiller M,Ağaoğlu B,Cetinel S,Yeğen BÇ

更新日期：2009-03-01 00:00:00

abstract：:Juvenile Oncorhynchus mykiss (average weight: 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was ele...

journal_title：Environmental toxicology and pharmacology

authors： Lee JW,Deng DF,Lee J,Kim K,Jung HJ,Choe Y,Park SH,Yoon M

更新日期：2020-11-01 00:00:00

abstract：:Earthworms are the key soil organisms, contribute to many positive ecological services that could be degraded by pesticides and other soil pollutants such as heavy metals. Chemicals usually occur as mixtures in the environmental systems which can lead synergistic effects. The assessment and characterization of soil po...

journal_title：Environmental toxicology and pharmacology

authors： Uwizeyimana H,Wang M,Chen W,Khan K

更新日期：2017-10-01 00:00:00

abstract：:A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon f...

journal_title：Environmental toxicology and pharmacology

authors： Koski P,Bäckman C,Pelkonen O

更新日期：2005-01-01 00:00:00

abstract：:Four extracts were prepared from the roots and leaves of Moricandia arvensis: root chloroform extract (ChlR), leaf chloroform extract (ChlL), root ethyl acetate extract (EAR) and leaf ethyl acetate extract (EAL). The genotoxic and antigenotoxic properties of these extracts were investigated by assessing the induction ...

journal_title：Environmental toxicology and pharmacology

authors： Skandrani I,Boubaker J,Bouhlel I,Limem I,Ghedira K,Chekir-Ghedira L

更新日期：2010-07-01 00:00:00

abstract：:The effects of bis(2-ethylhexyl) phthalate (DEHP), γ-hexachlorocyclohexane (γ-HCH), and 17β-estradiol (E2) on the fry stage of medaka were investigated. The medaka fry were exposed to different concentrations (0.01, 0.1, 1, and 10μg/L) of these chemicals for 3 weeks after hatching. Then, mortality, body weight, sex ra...

journal_title：Environmental toxicology and pharmacology

authors： Chikae M,Ikeda R,Hatano Y,Hasan Q,Morita Y,Tamiya E

更新日期：2004-09-01 00:00:00