Abstract：
:Despite a strong association between cigarette smoking and alarming increase in mortality rate from smoking-related diseases, around 35-40% of the world's population continues to smoke and many more are being exposed to environmental tobacco smoke. Since the role of free radicals and oxidative damage in the pathogenesis of smoking-related diseases has been suggested, bacoside A, a potent antioxidant was tested for its ability to protect against cigarette smoking-induced toxicity in terms of lactate dehydrogenase (LDH) and its isoenzymes. Rats were exposed to cigarette smoke and simultaneously administered with bacoside A, for a period of 12 weeks. Total LDH activity was assayed in serum, lung, heart, brain, liver and kidney, and serum LDH isoforms were separated electrophoretically. Cigarette smoke exposure resulted in significant increase in serum LDH and its isoenzymes with a concomitant decrease in these organs. These alterations were prevented by administration of bacoside A. Excessive oxidants from cigarette smoke is known to cause peroxidation of membrane lipids leading to cellular damage, thereby resulting in the leakage of LDH into the circulation. Bacoside A could have rendered protection to the organs by stabilizing their cell membranes and prevented the release of LDH, probably through its free radical scavenging and anti-lipid peroxidative effect.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Anbarasi K,Sabitha KE,Devi CSdoi
10.1016/j.etap.2005.03.006subject
Has Abstractpub_date
2005-09-01 00:00:00pages
345-50issue
2eissn
1382-6689issn
1872-7077pii
S1382-6689(05)00069-4journal_volume
20pub_type
杂志文章abstract：:Cadmium (Cd) and lead (Pb) show adverse effects on hemoglobin. But most studies are focussed on one single agent. In this study, we observed the main and interactive effects of Cd and Pb on the hemoglobin level in a Chinese population. A total of 308 persons (202 women and 106 men), living in controlled and polluted a...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.02.005
更新日期：2015-03-01 00:00:00
abstract：:The Brca1 and Brca2 tumor suppressor genes are involved in the maintenance of genomic integrity as they facilitate error free DNA repair. This study was designed to understand the role of Brca1 and Brca2 in betel nut (BN) induced chronic and transgenerational carcinogenesis in mice. Young male and female Swiss Albino ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.09.006
更新日期：2011-01-01 00:00:00
abstract：:The metabolites of oestrogenic substances of plant origin, phyto-oestrogens, have been proposed as cancer-protective agents in Asian and vegetarian populations. The two principle classes of these weak oestrogens are isoflavonoids and mammalian lignans. The former is derived from soya-based foods and the latter from oi...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(99)00018-6
更新日期：1999-07-01 00:00:00
abstract：:Genetic variations in the glutathione S-transferase genes GSTT1 and GSTM1 have been widely studied, and homozygous deletions or null genotypes have been reported in different populations. Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2018.10.008
更新日期：2019-01-01 00:00:00
abstract：:The present investigation was aimed to evaluate the pulmonary toxicity of 10 and 25nm gold nanorods (GNRs) following intra-tracheal instillation in rats using bronchoalveolar lavage (BAL) fluid and lung histopathological analysis. The GNRs displayed that the dose-dependent toxicity via elevated lactate dehydrogenase l...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.04.015
更新日期：2017-06-01 00:00:00
abstract：:In this study we analyzed and characterized 29 psychoactive remedies, illicit drugs and their metabolites in single stages of wastewater treatment plants in the capital city of Slovakia. Psychoactive compounds were present within all stages, and tramadol was detected at a very high concentration (706 ng/L). Significan...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.02.018
更新日期：2015-03-01 00:00:00
abstract：:Glyphosate is the active ingredient and polyoxyethyleneamine, the major component, is the surfactant present in the herbicide Roundup formulation. The objective of this study was to analyze potential cytotoxicity of the Roundup and its fundamental substance (glyphosate). Albino male rats were intraperitoneally treated...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.06.001
更新日期：2009-11-01 00:00:00
abstract：:Adult mallard ducks and northern bobwhite quail were exposed to 0, 10, 50, or 150mg perfluorooctane sulfonate (PFOS)/kg in the diet for up to 21 weeks. Adult health, body and liver weight, feed consumption, gross morphology and histology of body organs, and reproduction were examined. Due to mortality, birds exposed t...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2006.04.008
更新日期：2007-01-01 00:00:00
abstract：:In this study with crucian carp (Carassius auratus gibelio), the effect on enrofloxacin (EF) and its metabolite ciprofloxacin (CF) and on the activity of cytochrome P450 1A (CYP1A) and cytochrome P450 3A (CYP3A) was estimated following the oral administration of rifampicin (RIF) (12mg/kg) and β-naphthoflavone (BNF) (1...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.07.015
更新日期：2016-09-01 00:00:00
abstract：:Susceptibility is well-recognized as a potentially important aspect of health risk assessment, particularly for groups such as pregnant women and their fetuses, infants, children, the elderly, and the infirm, that are known or suspected to be more vulnerable to environmental insults. More recently, it has become appar...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)10020-5
更新日期：1997-12-01 00:00:00
abstract：:Drug-induced blood dyscrasias can be either acute and predictable or delayed and unpredictable (idiosyncratic). The predictable toxicity is relatively easy to reproduce with in vitro models, although they may not work for drugs that require bioactivation. It is very unlikely that idiosyncratic blood dyscrasias can be ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2005.07.003
更新日期：2006-02-01 00:00:00
abstract：:We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the um...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(97)00026-4
更新日期：1997-09-01 00:00:00
abstract：:As a first-line anti-tuberculosis drug, isoniazid has a serious adverse side effect: hepatotoxicity. Therefore, the assessment and monitoring of hepatotoxicity from isoniazid to prevent liver injury are great concerns. In this experiment, we compared the levels of ALT in plasma and DNA methylation. 30 male SD rats wer...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.07.001
更新日期：2011-11-01 00:00:00
abstract：:The toxicity of chlorobenzenes to Tetrahymena growth metabolism was studied by microcalorimetry. The growth constant (k), peak time (T) and generation times (T(G)) were calculated. IC(50) of chlorobenzenes was obtained through the kinetic parameters. The results suggested that the order of toxicity was 1,2,4-trichloro...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2012.01.009
更新日期：2012-05-01 00:00:00
abstract：:The hypothesis that temperature variation is able to modify the chronic toxicity of the antibiotic florfenicol (FLO) to Daphnia magna was tested in the present study. Twenty-one day laboratory bioassays were carried out at 20 and 25 °C. FLO concentrations and its potential decay during the assays were checked by spect...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.09.001
更新日期：2013-11-01 00:00:00
abstract：:Exposure to lead (Pb) or polychlorinated biphenyls (PCBs) during early development has been associated with deficits in cognitive function in children (Pediatrics 87 (1991) 219; N. Engl. J. Med. 335 (1996) 783). These effects persist in the child long after exposure has ceased and body burdens have diminished. Despite...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(02)00029-7
更新日期：2002-09-01 00:00:00
abstract：:Since hypoxia-inducible factor-1α (HIF-1α) is the key transcription factor that enables cells to survive in hypoxia, we have investigated whether an upregulation of HIF-1α prevents the noise-induced hearing loss in BALB/c hybrid mice, which were intraperitoneally injected with CoCl(2) (a HIF-1α inducer) and exposed to...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.10.002
更新日期：2011-01-01 00:00:00
abstract：:The purpose of the present study was to assess do selected pesticides as well as their binary combinations act as inhibitors of P-glycoprotein (P-gp) activity of NIH 3T3 mouse fibroblasts stably transfected with human MDR1 gene (NIH 3T3/MDR1). As a result of P-gp inhibition, the increase of intracellular accumulation ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2006.04.002
更新日期：2006-11-01 00:00:00
abstract：:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/s1382-6689(98)00006-4
更新日期：1998-06-02 00:00:00
abstract：:To explore the effects of microcystin-LR (MC-LR), a hepatotoxin, on the incidence of liver lipid metabolism abnormality, and the potential molecular mechanisms of action, healthy male Balb/c mice were intraperitoneally injected with MC-LR at doses of 0, 5, 10, and 20 μg/kg/d for 14 days. Hepatic histopathology and ser...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2015.05.002
更新日期：2015-07-01 00:00:00
abstract：:A simple analogue of well known natural antioxidant glutathione (GSH) called S-allyl-glutathione (SAG) was evaluated against carbon tetrachloride (CCl4)-induced oxidative stress liver injury in rat. Pretreatment of SAG attenuated the CCl4-toxicity induced elevation of liver injury markers such as enzymes (AST, ALT, GG...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.12.006
更新日期：2018-03-01 00:00:00
abstract：:There is controversy as to whether low-level chronic exposure to methylmercury (MeHg) through maternal fish consumption may cause subtle effects in the developing child, owing in part to the potential ameliorating effects of beneficial seafood nutrients. The aim of the present investigation was to assess the ameliorat...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.03.007
更新日期：2009-07-01 00:00:00
abstract：:Antiretroviral drugs (ARVs) are hazardous therapeutic pharmaceuticals present in South African surface water. Efavirenz is an ARV commonly used in human immunodeficiency virus (HIV) treatment in South Africa. Although little is known about the toxic effects of efavirenz on fish health, threats of toxicity to the aquat...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2017.09.017
更新日期：2017-12-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is considered as a valid target in the clinical trials of anticancer therapy and tyrosine kinase inhibitors (TKIs) of EGFR are approved for cancer treatments. In present work, cucurbitacin IIb (CuIIb) was confirmed to exhibit the proliferation inhibitory activity in A549 cells. ...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103542
更新日期：2021-01-01 00:00:00
abstract：:Hydroquinone (HQ) is a myelotoxin that is found in many foods and formed through the metabolism of benzene. HQ is genotoxic in several in vitro and in vivo test systems, inducing micronuclei (MN), sister-chromatid exchange (SCE), and chromosomal aberrations. The aim of the current study was to explore the protective e...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2007.07.002
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2020.103323
更新日期：2020-04-01 00:00:00
abstract：OBJECTIVES:The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level. METHODS:The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of m...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.07.007
更新日期：2016-09-01 00:00:00
abstract：:In this study, the hepatoprotective effect of dieckol on carbon tetrachloride (CCl4) induced hepatic damages in ICR mice liver was investigated. Mice were randomly divided into 4 groups such as saline treated (negative control), CCl4 treated (positive control), CCl4+dieckol (5mg/kg mouse) and CCl4+dieckol (25mg/kg mou...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2013.02.013
更新日期：2013-05-01 00:00:00
abstract：:We investigated whether treatment with N-acetylcysteine (NAC) reduces oxidative stress intensity and restores the expression and activities of superoxide dismutase (Sod1, SOD), catalase (Cat, CAT) and glutathione peroxidase (Gpx1, GPx) in lead-exposed workers. The exposed population was divided randomly into two group...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.etap.2014.01.024
更新日期：2014-03-01 00:00:00
abstract：:Mitochondrial damage can trigger mitophagy and eventually suppress proliferation. However, the effect of mitophagy on proliferation remains unclear. In this study, HepG2 cells were used to assess mitophagy and proliferation arrest in response to As2O3 exposure. The stimulatory effect of As2O3 on mitophagy was investig...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2016.06.006
更新日期：2016-07-01 00:00:00
