当前位置： SCI文献检索 > ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY期刊下所有文献 > Modulation of rifampicin toxicity by 6 MFA, an interferon inducer obtained from fungus Aspergillus ochraceus.

Modulation of rifampicin toxicity by 6 MFA, an interferon inducer obtained from fungus Aspergillus ochraceus.

Abstract：

:The effect of 6 MFA (Sixth mycelial fraction of acetone), an interferon inducer obtained from fungus Aspergillus ochraceus, on rifampicin toxicity was studied in rats. Chronic oral administration of rifampicin (1 g/kg per day) for 30 days produced thrombocytopenia, hemolytic anaemia, transient leukopenia and increased nucleated cells in bone marrow and decreased weights of thymus and spleen significantly in male rats. Furthermore, chronic administration of rifampicin induced significant increase in cytochrome P-450 contents, lipid peroxidation (LPO) and superoxide dismutase (SOD) activity in liver and bone marrow. Simultaneous administration of 6 MFA (100 mg/kg; i.p.) on alternate days for a period of 30 days prevented most of the adverse effects of rifampicin, mentioned earlier and also restored the hepatic architecture histologically. The LPO, cytochrome P 450 content, lymphocyte and bone marrow cell counts returned to normal level whereas SOD activity was further increased. The 6 MFA treatment enhanced the SRBC antibody litre in rifampicin-treated rats. Thus, beneficial effects of 6 MFA in the amelioration of mediated rifampicin toxicity observed in the present study may be through induction of interferons and their associated effects.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Dhuley JN,Naik SR

doi

10.1016/s1382-6689(98)00006-4

subject

Has Abstract

pub_date

1998-06-02 00:00:00

pages

237-43

issue

4

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(98)00006-4

journal_volume

5

pub_type

杂志文章

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