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The influence of aripiprazole and olanzapine on neurotransmitters level in frontal cortex of prenatally stressed rats.

Abstract：

OBJECTIVES:The study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level. METHODS:The effects of ARI (1.5mg/kg) and OLA (0.5mg/kg) were studied by means of microdialysis in freely moving rats (observation time 120min). The level of neurotransmitters (DA, 5-HT, NA) and their metabolites (DOPAC, HVA, 5-HIAA) was analyzed by HPLC with coulochemical detection. RESULTS:Obtained results indicate that after a single administration of ARI and OLA in the prenatally stressed rats the increase of DA, DOPAC, and 5-HT was observed. In turn ARI administration increase the level of HVA and 5-HIAA and also decrease the level of NA. After OLA administration the level of NA and HVA increased and no significant change in 5-HIAA was observed. CONCLUSION:Alterations observed as a result of ARI and OLA administration may be pivotal in identifying animal models of mental disorders and in the analysis of neuroleptics effectiveness.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Ratajczak P,Kus K,Gołembiowska K,Noworyta-Sokołowska K,Woźniak A,Zaprutko T,Nowakowska E

doi

10.1016/j.etap.2016.07.007

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

122-130

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(16)30185-5

journal_volume

46

pub_type

杂志文章

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