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Silver nanoparticles alter the permeability of sheep pleura and of sheep and human pleural mesothelial cell monolayers.

Abstract：

:Nanoparticles have been implicated in the development of pleural effusions in exposed factory workers while in experimental animal studies it has been shown that they induce inflammation, fibrosis and carcinogenesis in the pleura. The scope of this study was to investigate the direct effects of silver nanoparticles exposure on the membrane permeability of sheep parietal pleura, of primary sheep pleural cell monolayers and on a human mesothelial cell line. Our findings suggest that acute (30min) exposure increases the pleural permeability ex vivo, while longer (24h) exposure in vivo leads to late decrease of the pleural cell monolayers permeability.

journal_name

Environ Toxicol Pharmacol

journal_title

Environmental toxicology and pharmacology

authors

Arsenopoulou ZV,Taitzoglou IA,Molyvdas PA,Gourgoulianis KI,Hatzoglou C,Zarogiannis SG

doi

10.1016/j.etap.2017.02.009

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

212-215

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(17)30040-6

journal_volume

50

pub_type

杂志文章

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