Abstract：
:The dominant lethal assay was utilized to assess the reproductive performance in male mice, possible genetic hazards, and persistent damage of aluminum (Al). Al chloride, AlCl(3), was administered subcutaneously to CD-1 adult male mice at dosages of 0, 7, or 13mg Al/kg body weight/day for 2 weeks of pre-mating periods. Females were not dosed at any time during this study. At the end of the exposure period, each male was caged with three virgin females each day. The mean mating frequencies of the Al-treated groups reduced consistently from week 4 to 6, and a dramatic reduction in male fertility was also observed. However, the mating frequency restored to near normal control levels as the experiment terminated. Results showed significantly higher numbers of post-implantation losses, foetal mortality, and induced petechial haemorrhage; also significant decreases in body weights of viable foetus throughout weeks 3-8 in the Al-treated groups. The weights of the reproductive organs of the Al-dosed animals decreased significantly as Al accumulation increased in the testes. The spermatogenetic impairment within the seminiferous tubules was also apparent. Nevertheless, these disturbances disappeared at the end of the experiments. In summary, the results demonstrated that Al exerted substantial hazards on male reproductive function and produced genetic toxicity. However, these effects were found to be reversible.
journal_name
Environ Toxicol Pharmacoljournal_title
Environmental toxicology and pharmacologyauthors
Guo CH,Lu YF,Hsu GSdoi
10.1016/j.etap.2004.11.007subject
Has Abstractpub_date
2005-07-01 00:00:00pages
135-41issue
1eissn
1382-6689issn
1872-7077pii
S1382-6689(04)00258-3journal_volume
20pub_type
杂志文章abstract：:Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body wei...
journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
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doi：10.1016/j.etap.2011.01.006
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2005.04.001
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更新日期：2016-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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更新日期：2017-01-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2008.02.009
更新日期：2008-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2007.09.001
更新日期：2008-01-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2009.03.007
更新日期：2009-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章,评审
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2011.08.007
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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journal_title：Environmental toxicology and pharmacology
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更新日期：2018-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.08.019
更新日期：2014-11-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.06.007
更新日期：2014-07-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2010.02.003
更新日期：2010-05-01 00:00:00
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journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
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更新日期：1996-10-15 00:00:00
abstract：:Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxida...
journal_title：Environmental toxicology and pharmacology
pub_type： 杂志文章
doi：10.1016/j.etap.2014.11.012
更新日期：2015-01-01 00:00:00
