Differential organ expression patterns of thyroid hormone receptor isoform genes in p,p'-DDE-treated adult male common frog, Rana temporaria.

Abstract:

:Using the European common frog, Rana temporaria, as a model, we have studied the organ-specific gene expression patterns of thyroid hormone receptor isoforms after exposure to an organochlorine (OC) compound, p,p'-DDE. Four groups of frogs were subcutaneously injected with p,p'-DDE at 0.01, 0.1, 1 and 10mg/kg body weight, respectively. In addition, one group, serving as the control group, was injected with pure corn oil. TH receptor isoforms (TRα and TRβ) gene expressions were evaluated in the brain, kidney, testis and liver using real-time PCR with gene-specific primers. Our results show that p,p'-DDE doses induced slight elevations of TRα and TRβ mRNA in the brain. In the testis, p,p'-DDE induced an initial significant 3-fold increase of TRα mRNA at 0.01mg/kg and thereafter clear dose-dependent decreases of TRα mRNA levels were observed. For testicular TRβ mRNA levels, p,p'-DDE induced a slight elevation at 0.01mg/kg and thereafter significant decreases in TRβ mRNA levels were observed. p,p'-DDE induced significant 2-4-fold elevations of both TR isoforms in frog kidney. The strongest transcriptional effect of p,p'-DDE on TR isoforms was observed in the kidney. While TRα mRNA was not measurable in the liver, p,p'-DDE induced an initial 1.7-fold increase at 0.01mg/kg of TRβ mRNA and thereafter an apparent dose-dependent decrease was observed. The relative abundance of TRα and TRβ gene expression in different organs are in the order: kidney>testis>brain>liver. While the induction TRα and TRβ might result to hypersensitivity and subsequent gain of biological functions, the inhibition might result to loss of biological function. Given the high persistency in the environment and continued use in developing countries coupled with the tendency for global atmospheric transport, DDT and its metabolites such as p,p'-DDE will remain a focus of concern both for scientific and societal reasons.

authors

Arukwe A,Jenssen BM

doi

10.1016/j.etap.2005.05.008

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

485-92

issue

3

eissn

1382-6689

issn

1872-7077

pii

S1382-6689(05)00099-2

journal_volume

20

pub_type

杂志文章
  • Neurotoxic effects of acute and subacute formaldehyde exposures in mice.

    abstract::In this study, the effects of acute and subacute formaldehyde (FA) exposures on spontaneous locomotor activity (SLMA), wet dog shake (WDS) behavior and pentylenetetrazole (PTZ) induced seizures were evaluated in Balb/C mice. SLMA was concentration dependently reduced after acute FA exposures at 1.8, 3.2, 4.5, 6.4, 9.7...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(01)00109-0

    authors: Usanmaz SE,Akarsu ES,Vural N

    更新日期:2002-03-01 00:00:00

  • Food from genetically modified organisms and potential for food allergy.

    abstract::Crops produced through genetic modification are beginning to reach the market and many genetically-modified crops are under development. Since genetic modification results in the introduction of new proteins into the food plant the safety of the newly introduced proteins must be assessed. The potential allergenicity o...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(97)10052-7

    authors: Taylor SL

    更新日期:1997-11-01 00:00:00

  • Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage.

    abstract::Hepatotoxicity is the most serious adverse effect related to tuberculosis treatment which interrupts the successful completion of tuberculosis treatment. The purpose of this study was to assess therapeutic effect of thymoquinone (TQ) against anti-tuberculosis drugs (ATD) induced liver damage. Rats were treated with AT...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.07.010

    authors: Jaswal A,Sinha N,Bhadauria M,Shrivastava S,Shukla S

    更新日期:2013-11-01 00:00:00

  • Cytotoxicity of HC Orange NO. 1 to L929 fibroblast cells.

    abstract::HC Orange No. 1 (HCO1, 2-nitro-4'-hydroxydiphenylamine) (CAS No. 54381-08-7) is used as a colorant in commercial hair dyes. The cytotoxicity of HCO1 to L929 mouse connective tissue fibroblast cells was determined by use of a battery of endpoints that included electron transport activity determined by the MTT assay and...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2008.06.002

    authors: Liu H,Chen J,Jiang J,Giesy JP,Yu H,Wang X

    更新日期:2008-11-01 00:00:00

  • Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats.

    abstract::The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injecti...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.11.017

    authors: Vanitha P,Uma C,Suganya N,Bhakkiyalakshmi E,Suriyanarayanan S,Gunasekaran P,Sivasubramanian S,Ramkumar KM

    更新日期:2014-01-01 00:00:00

  • Combined toxicity of silica nanoparticles and methylmercury on cardiovascular system in zebrafish (Danio rerio) embryos.

    abstract::This study was to investigate the combined toxicity of silica nanoparticles (SiNPs) and methylmercury (MeHg) on cardiovascular system in zebrafish (Danio rerio) embryos. Ultraviolet absorption analysis showed that the co-exposure system had high absorption and stability. The dosages used in this study were based on th...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2016.05.004

    authors: Duan J,Hu H,Li Q,Jiang L,Zou Y,Wang Y,Sun Z

    更新日期:2016-06-01 00:00:00

  • Magnolol reduces UVB-induced photodamage by regulating matrix metalloproteinase activity.

    abstract::In this study, we evaluated the anti-photoaging activity of magnolol in UV-irradiated hairless mice, and hypothesized that magnolol would prevent photoaging in these animals. The inhibitory effect of magnolol on wrinkle formation was determined by analyzing the skin replica, histologically examining the epidermal thic...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.12.001

    authors: Im AR,Song JH,Lee MY,Chae S

    更新日期:2015-01-01 00:00:00

  • Impact of long term Fe³⁺ toxicity on expression of glutathione system in rat liver.

    abstract::The free radicals within the body, produced by metabolic activities or derived from environmental sources are relatively related to hepatoxicity. Since heavy metals including iron have the ability to produce free radicals, the liver glutathione system neutralizes them to protect cells against any damage. The objective...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.12.007

    authors: Budak H,Gonul N,Ceylan H,Kocpinar EF

    更新日期:2014-01-01 00:00:00

  • Inhibition of intercellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in mouse hepa1c1c7 cells.

    abstract::Inhibition of intercellular communication (IC) between hepa1c1c7 cells was used as a possible bioassay to predict tumor promoting potency of polyhalogenated aromatic hydrocarbons (PAHs). Relative potencies with regard to 2,3,7,8-TCDD to inhibit IC and to induce cytochrome P450IA1/2 (EROD) in these hepa1c1c7 cells were...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/1382-6689(95)00006-2

    authors: De Haan LH,Halfwerk S,Hovens SE,De Roos B,Koeman JH,Brouwer A

    更新日期:1996-02-15 00:00:00

  • Prenatal alcohol exposure reduces 5-HT concentration in mouse intestinal muscle and mucosa.

    abstract::The influence of prenatal alcohol exposure on the serotoninergic system in the brain has been well studied, however its influence on the serotoninergic system in the gastrointestinal system remains unknown. The objective of the study was to use a mouse model of prenatal alcohol exposure to investigate the effects on s...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2018.05.011

    authors: Dylag KA,Fidalgo SVS,Gard PR,Patel BA

    更新日期:2018-07-01 00:00:00

  • Use of acetylcholinesterase, glutathione S-transferase and cytochrome P450 1A1 in Capoeta umbla as biomarkers for monitoring of pollution in Uzuncayir Dam Lake (Tunceli, Turkey).

    abstract::Uzuncayir Dam Lake is one of the most important water bodies in Tunceli. It is polluted by domestic wastewaters together with natural contamination and pesticides, which have had cumulatively negative effects. This study analyzes the effects of pollution by using the fish species, Capoeta umbla as a sentinel species, ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.04.001

    authors: Yildirim NC,Yildirim N,Danabas D,Danabas S

    更新日期:2014-05-01 00:00:00

  • Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

    abstract::Grape-seed proanthocyanidins (GSPs) have been shown to function as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. However, little is known about their anti-inflammatory properties and mechanisms of action. The specific focus being its effects on the MAP kinases and nuclear facto...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.11.018

    authors: Chu H,Tang Q,Huang H,Hao W,Wei X

    更新日期:2016-01-01 00:00:00

  • Involvement of mitochondrial ATP-sensitive potassium channels in etomidate preconditioning-induced protection in human myeloid HL-60 cells.

    abstract::Exposure of HL-60 cells, a human myeloid cell line, to 500μM etomidate for 24h reduced cell viability and increased nitric oxide production and mitochondrial permeability transition pore (mPTP) opening. Preconditioning (1h) with 1μM etomidate 4h before exposure to the 500μM dose of etomidate attenuated those detriment...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2010.02.003

    authors: Zhang X,Xiong J,Jiao Y,Wang G,Zuo Z

    更新日期:2010-05-01 00:00:00

  • Analysis of functional effects of a mixture of five pesticides using a ray design.

    abstract::The protection of human health from the adverse effects of cumulative environmental exposure to chemical mixtures is an important issue. Of particular interest is the detection and characterization of interaction among chemicals in complex mixtures. Response surface methodology, often supported by factorial designs, i...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.03.012

    authors: Gennings C,Carter WH Jr,Casey M,Moser V,Carchman R,Simmons JE

    更新日期:2004-11-01 00:00:00

  • Chemical exposure in occupational settings and related health risks: a neglected area of research in Pakistan.

    abstract::In Pakistan a huge number of workers is routinely exposed to various types of chemical contaminants but there is a dearth of information as to the impact of these agents, due to a lack of a routine surveillance system and proper reporting. Prolonged and sometimes acute occupational exposures to varied organic chemical...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.etap.2012.02.009

    authors: Kamal A,Malik RN,Fatima N,Rashid A

    更新日期:2012-07-01 00:00:00

  • Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis.

    abstract::We previously reported that Astragalus polysaccharide (APS) extracted from Chinese medicine Astragalus membranaceus (Fisch.) Bge, attenuates hypertrophy of neonatal rat ventricular myocytes (NRVMs) induced by isoproterenol (Iso). The present study was designed to investigate the effects and the possible mechanism of A...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.03.014

    authors: Luan A,Tang F,Yang Y,Lu M,Wang H,Zhang Y

    更新日期:2015-05-01 00:00:00

  • DHF-BAHPC molecule exerts ameliorative antioxidant status and reduced cadmium-induced toxicity in zebrafish (Danio rerio) embryos.

    abstract::In this study, we report the antioxidant and antitoxic potential of chemically synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone (DHF) with two molecules of Fmoc-t...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103425

    authors: Mohankumar T,Lalithamba HS,Manigandan K,Muthaiyan A,Elangovan N

    更新日期:2020-10-01 00:00:00

  • Evaluating the human response to chemicals: odor, irritation and non-sensory factors.

    abstract::Although airborne chemicals can directly elicit adverse reactions via stimulation of the olfactory and trigeminal nerves, such as sensory irritation of the mucous membranes of the eyes, nose and throat, an individual's subjective experience is often the result of a complex sequence of events involving those sensory, p...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2004.12.023

    authors: Smeets MA,Dalton PH

    更新日期:2005-05-01 00:00:00

  • Assessment of vascular function in Mexican women exposed to polycyclic aromatic hydrocarbons from wood smoke.

    abstract::The use of solid fuels for cooking and heating is likely to be the largest source of indoor air pollution on a global scale; these fuels emit substantial amounts of toxic pollutants such as polycyclic aromatic hydrocarbons (PAHs) when used in simple cooking stoves (such as open "three-stone" fires). Moreover, indoor a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.07.014

    authors: Ruiz-Vera T,Pruneda-Álvarez LG,Ochoa-Martínez ÁC,Ramírez-GarcíaLuna JL,Pierdant-Pérez M,Gordillo-Moscoso AA,Pérez-Vázquez FJ,Pérez-Maldonado IN

    更新日期:2015-09-01 00:00:00

  • Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats.

    abstract::Diethylnitrosamine (DEN) treatment increases the generation of reactive oxygen species (ROS), apoptosis, necrosis and proliferation in the liver. Blueberries (BB; Vaccinium corymbosum L.) contain polyphenols and other active components and have high antioxidant capacities. We investigated the effect of BB pretreatment...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2013.05.014

    authors: Bingül İ,Başaran-Küçükgergin C,Tekkeşin MS,Olgaç V,Doğru-Abbasoğlu S,Uysal M

    更新日期:2013-09-01 00:00:00

  • Prenatal exposure to methylmercury changes dopamine-modulated motor activity during early ontogeny: age and gender-dependent effects.

    abstract::We have shown previously that prenatal exposure of rats to 0.5 mg/kg/day of methylmercury (MeHg) produces gender-dependent changes in motor activity in adulthood. In the present study we have investigated whether changes in motor activity could also be found during early ontogeny of the offspring. Pregnant rats were t...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/s1382-6689(00)00060-0

    authors: Giménez-Llort L,Ahlbom E,Daré E,Vahter M,Ögren S,Ceccatelli S

    更新日期:2001-01-01 00:00:00

  • Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro.

    abstract::Acetylcholinesterase (AChE) is an important part of cholinergic nerves where it participates in termination of neurotransmission. AChE can be inhibited by e.g. some Alzheimer disease drugs, nerve agents, and secondary metabolites. In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric c...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.01.001

    authors: Pohanka M

    更新日期:2014-01-01 00:00:00

  • The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats.

    abstract::Ulcerative colitis (UC) is a disease of increased worldwide prevalence. UC progression is associated with serious complications that leave the patient with considerable health burdens. Nifuroxazide is an oral nitrofuran antibiotic used as antidiarrheal medication. The current study places an emphasis on investigating ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2020.103433

    authors: El-Far YM,Elsherbiny NM,El-Shafey M,Said E

    更新日期:2020-10-01 00:00:00

  • Mutagenic and genotoxic assessment of atrazine-based herbicide to freshwater fish Channa punctatus (Bloch) using micronucleus test and single cell gel electrophoresis.

    abstract::The mutagenic and genotoxic effect of 'Rasayanzine', an atrazine herbicide, was carried out in fish Channa punctatus using micronucleus and single cell gel electrophoresis (SCGE) assays. Three sub-lethal concentrations of the test material viz., SL-I (1/5th LC(50)=∼8.48 mgL(-1)), SL-II (1/8th LC(50)=∼5.30 mgL(-1)) and...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2010.12.001

    authors: Nwani CD,Nagpure NS,Kumar R,Kushwaha B,Kumar P,Lakra WS

    更新日期:2011-03-01 00:00:00

  • Activation of human eosinophils with palladium nanoparticles (Pd NPs): importance of the actin cytoskeleton in Pd NPs-induced cellular adhesion.

    abstract::Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it ...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2017.12.002

    authors: Chhay P,Murphy-Marion M,Samson Y,Girard D

    更新日期:2018-01-01 00:00:00

  • A focus on the human lens in vitro.

    abstract::The lens is a unique organ in that it is avascular and non-innervated, obtaining all nutrients from the aqueous and vitreous humours that bathe the lens. All lenses attempt to achieve the same goal, namely to maintain transparency and focus light on to the retina. However, the mechanisms by which these processes are m...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2005.07.012

    authors: Wormstone IM,Collison DJ,Hansom SP,Duncan G

    更新日期:2006-02-01 00:00:00

  • A multi-biomarker risk assessment of the impact of brominated flame retardant-decabromodiphenyl ether (BDE209) on the antioxidant system of earthworm Eisenia fetida.

    abstract::Decabromodiphenyl ether (BDE209) is the major contaminant at e-waste recycling sites (EWRSs), and its potential toxicological effects on terrestrial organisms have received extensive attention. However, the impacts of BDE209 on the antioxidant defense system in terrestrial organisms remain vague. Therefore, indoor inc...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.06.007

    authors: Zhang W,Liu K,Chen L,Chen L,Lin K,Fu R

    更新日期:2014-07-01 00:00:00

  • Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/β-catenin signaling pathway in rat osteoblasts.

    abstract::Exposure to aluminum (Al) suppresses bone formation. Osteoblastic differentiation plays a key role in the process of bone formation. However, the effect of Al on osteoblastic differentiation is still controversial, and the mechanism remains unclear. To investigate the effect of Al on osteoblastic differentiation and w...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2015.11.023

    authors: Cao Z,Fu Y,Sun X,Zhang Q,Xu F,Li Y

    更新日期:2016-03-01 00:00:00

  • Effects of cigarette smoke on Holter ECG recordings in patients with arterial hypertension. Part 2: Parameters of heart rate turbulence.

    abstract:UNLABELLED:The studies aimed at evaluation of cigarette smoke effect on heart rate turbulence (HRT) in patients with arterial hypertension (AH). 223 consecutive individuals were qualified to the studies. The following groups of patients not suffering from other disease which may affect HRT were distinguished: 1--patien...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2014.01.022

    authors: Gać P,Sobieszczańska M

    更新日期:2014-03-01 00:00:00

  • Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

    abstract::Gambogenic acid, identified from Gamboge, is responsible for anti-tumor effects, and has been shown to be a potential molecule against human cancers. In this study, the molecular mechanism of gambogenic acid-induced apoptosis in HepG2 cells was investigated. Gambogenic acid significantly inhibited cell proliferation a...

    journal_title:Environmental toxicology and pharmacology

    pub_type: 杂志文章

    doi:10.1016/j.etap.2011.12.006

    authors: Yan F,Wang M,Li J,Cheng H,Su J,Wang X,Wu H,Xia L,Li X,Chang HC,Li Q

    更新日期:2012-03-01 00:00:00